Pentaerythritol trinitrate metabolism by the rat

Add time:07/26/2019    Source:sciencedirect.com

Rats were studied after being given a single dose of 14C-pentaerythritol trinitrate by gavage. The labeled components of the blood, urine and gastrointestinal tract were identified by thin-layer chromatography and assayed quantitatively by radioscanning. Pentaerythritol trinitrate was found to be absorbed and excreted rapidly by the rat. The drug metabolites were pentaerythritol, pentaerythritol mononitrate and pentaerythritol dinitrate. Comparisons of the data with the results of similar studies with pentaerythritol tetranitrate (PETN) and nitroglycerin showed that pentaerythritol trinitrate was absorbed much faster than PETN and almost as quickly as nitroglycerin, and that the urinary excretion of pentaerythritol trinitrate proceeded at the highest rate. Additionally, pentaerythritol trinitrate was the only one of the three drugs which passed intact into the urine.

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