In this work, we theoretically study the excited state multiple proton transfer (ESMPT) mechanism of 9H-pyrido[3,4-b]indole (NOR) coupling with acetic acid (AcOH) in DCM solvent. We analyze structural changes, infrared (IR) vibrational spectra and charge redistribution, which reveals the tendenc...
Due to pralidoxime chloride's (2-PAM) positive charge, it's penetration through the blood brain barrier (BBB) and reactivation of organophosphate (OP) inhibited central nervous system (CNS) acetylcholinesterase (AChE) is poor. The results of CNS inhibited AChE are seizures. Pro-2-PAM (1-methyl-1...
We investigated the effects of diphenyleneiodonium (DPI) on superoxide production by complex I in mitochondria isolated from rat skeletal muscle. Superoxide production was measured indirectly as hydrogen peroxide production. In a conventional medium containing chloride, DPI strongly inhibited su...
3,7-Dinitrodibenzobromolium bisulfate (5) is prepared directly by reaction of 4,4-dinitrobiphenyl with sodium bromide and potassium persulphate in concentrated sulphuric acid. Reduction of the compound5 with SnCl 2 -HCl gives 3,7-diaminodibenzobromolium chloride (6). Reactions of the d...
The bis-dimethylaminoethyl derivative of quindoline (10H-indolo[3,2-b]quinoline), an alkaloid from the West African shrub Cryptolepis sanguinolenta, has been synthesised. This has been shown to have modest cytotoxicity, as well as inhibitory activity against the telomerase enzyme. It is hypothes...
The initial stage of organic film growth is considered to be vital for the carrier transport in organic thin-film transistors with bottom gate configuration. The same topographies of 40nm dinaphtho[2,3-b:2′,3′-f]thieno[3,2-b]thiophene (DNTT) films on para-sexiphenyl (p-6P) monolayer and bare S...
Roll-to-roll (R2R) production of organic transistors and circuits require patterned deposition of organic layers at high deposition rate. Here we demonstrate a vapour-jet process for the rapid deposition of the organic semiconductor dinaphtho[2,3-b:2′,3′-f]thieno[3,2-b]thiophene (DNTT). The de...
Low-voltage organic thin-film transistors (TFTs) based on four different small-molecule semiconductors (pentacene, DNTT (dinaphtho[2,3-b:2′,3′-f]thieno[3,2-b]thiophene), C10-DNTT and DPh-DNTT) were fabricated, and a detailed comparison of the semiconductor thin-film morphology, of the current-...
A series of 6H,13H-pyrazino[1,2-a;4,5-a′]diindole analogs was synthesized in order to probe the pharmacophore hypothesis for allosteric ligands of muscarinic M 2 receptors. The 3D structure of the novel ring system was determined by means of NMR spectroscopy and X-ray diffraction reveal...
The polycarbazoles have been proved to be a good organic semiconductor. These are investigated by quantum chemical studies using B3LYP density functional theory (DFT), and the studies have given a detailed understanding on the impact of carbazole units and an introduction to the electron donatin...
A new 5,11-dihydroindolo[3,2-b]carbazole-based bidentate ligand bearing two carboxylic groups, (3,3′-(indolo[3,2-b]carbazole-5,11-diyl)dipropionic acid, H2icdc), has been synthesized in two steps and then used for the construction of two metal–organic coordination polymers, namely [Zn3(dmf)2(i...
Two novel donor-π-acceptor type of conjugated polymers with thiophene or selenophene as the π-bridge between the electron-donating indolocarbazole and electron-accepting difluorobenzotriazole unit, were designed and synthesized through a palladium catalyzed Suzuki polymerization. The replaceme...
Two conjugated polymers based on dithienophosphole oxide, PBDT-O-DTPO and PBDT-T-DTPO, were synthesized. Two polymers were fairly soluble in chlorinated solvents, which is enough for device fabrication. According to the UV–vis spectra of films, PBDT-O-DTPO and PBDT-T-DTPO showed absorption onse...
Regioregular (P1) and random (P2) polymers were prepared by the reaction of equimolar amounts of dibromides M2 or M3 with bis(stannyl) monomer M1. The regioregularity of the conjugated chain in P1 was shown to affect considerably its optical properties. The HOMO/LUMO values and electrochemical b...
The formation of substituted benzimidazo[2,1-a]isoquinolines by the palladium-catalyzed intramolecular cyclization of 2-[2-(2-trimethylsilyl-ethynyl)-phenyl]-1H-benzimidazole is described. 5,6-Dihydrobenzimidazo[2,1-a]isoquinolines were formed directly during the condensation of a 1,2-phenylened...
An efficient route for the synthesis of benzimidazo[2,1-a]isoquinolines and its condensed analogues has been developed via the palladium-catalyzed cyclization/C–H activation of N-allyl and N-methallyl derivatives of benzimidazoles.
Direct, efficient syntheses of the benzimidazo[2,1-a]isoquinoline ring system have been achieved with 2-bromoarylaldehydes, terminal alkynes, and 1,2-phenylenediamines by a microwave-accelerated tandem process in which a Sonogashira coupling, 5-endo cyclization, oxidative aromatization, and 6-en...
A facile, efficient, and general synthetic method for iodo-substituted benzo[b]naphtho[2,1-d]thiophenes has been developed via a cascade cyclization of thioanisole-substituted aryldiynes using iodine. A new donor–π linker–acceptor (D–π–A) organic dye, G1, with the benzo[b]naphtho[2,1-d]thi...
Recombinant Mycobacterium sp. strain MR65 carrying dszABCD genes was used for desulfurization of 10-methylbenzo[b]naphtho[2,1-d]thiophene (10-methyl BNT) in the hexadecane phase. The specific activity was 25% of that of dibenzothiophene (DBT). One of two major metabolites of 10-methyl BNT produc...