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4-Hydroxybenzoic acid

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Name

4-Hydroxybenzoic acid

EINECS 202-804-9
CAS No. 99-96-7 Density 1.46 g/cm3
Solubility Water solubility: 5 g/L (20 °C) Melting Point 213-217 °C(lit.)
Formula C7H6O3 Boiling Point 336.2 °C at 760 mmHg
Molecular Weight 138.12 . Flash Point 171.3 °C
Transport Information Appearance white to beige crystalline powder
Safety 26-37/39-36 Risk Codes 36-36/37/38
Molecular Structure Molecular Structure of 99-96-7 (4-Hydroxybenzoic acid) Hazard Symbols IrritantXi
Synonyms

p-Oxybenzoesaure [German];Benzoic acid, p-hydroxy-;Benzoic acid, p-hydroxy;4-Carboxyphenol;Benzoic acid, 4-hydroxy-, monosodium salt;4-Hydroxybenzoate;Hydroxybenzenecarboxylic acid;4-Hydroxybenzoesaeure;Benzoic acid, 4-hydroxy-;Benzoic acid, 4-hydroxy;Acido p-idrossibenzoico [Italian];Potassium 4-hydroxybenzoate;Sodium 4-hydroxybenzoate;Hydroxybenzoic acid;p-salicylic acid;Kyselina 4-hydroxybenzoova [Czech];P-Hydroxybenzoic acid (PHBA);4-Hydroxy Benzoic Acid;p-hydroxybenzoic Acid;4-hydroxybenzoic acid;4-hydroxybenzenecarboxylic acid;Para Hydroxy Benzoic Acid[99-96-7];p-Hydroxy Benzoic Acid;

 

4-Hydroxybenzoic acid Chemical Properties

Molecular Formula: C7H6O3
Molecular Weight: 138.12 g/mol
EINECS: 202-804-9 
Index of Refraction: 1.615
Density: 1.375 g/cm3
Flash Point: 171.3 °C
Enthalpy of Vaporization: 61.14 kJ/mol
Boiling Point: 336.2 °C at 760 mmHg
Vapour Pressure: 4.48E-05 mmHg at 25 °C
Melting point: 213-217 °C(lit.)
Water solubility: 5 g/L (20 °C)
Appearance: White to beige crystalline powder
Structure of 4-Hydroxybenzoic acid (CAS NO.99-96-7):
                             
IUPAC Name: 4-Hydroxybenzoic acid
Product Categories: Pharmaceutical Raw Materials;Benzoic Acids (Building Blocks for Liquid Crystals);Functional Materials;Phenols;Aromatics;Impurities;Intermediates & Fine Chemicals;Carboxylic Acids;Alphabetical Listings;Flavors and Fragrances

4-Hydroxybenzoic acid Uses

 4-Hydroxybenzoic acid (CAS NO.99-96-7) is primarily known as the basis for the preparation of its ESTERS. As parabens, it was used as preservatives in cosmetics.

4-Hydroxybenzoic acid Production

 4-Hydroxybenzoic acid (CAS NO.99-96-7) is produced commercially from potassium phenoxide and carbon dioxide in the Kolbe-Schmitt reaction. It can also be produced in the laboratory by heating potassium salicylate with potassium carbonate to 240 °C, followed by treating with acid.

4-Hydroxybenzoic acid Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 210mg/kg (210mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: ATAXIA
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 45, Pg. 260, 1956.
mouse LD50 oral 2200mg/kg (2200mg/kg)   Drug Standards. Vol. 20, Pg. 89, 1952.
mouse LD50 subcutaneous 1050mg/kg (1050mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 128, Pg. 135, 1960.
rat LD50 intraperitoneal 340mg/kg (340mg/kg) BEHAVIORAL: MUSCLE WEAKNESS Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 51(1), Pg. 85, 1986.
rat LD50 oral > 10gm/kg (10000mg/kg) BEHAVIORAL: MUSCLE WEAKNESS
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 28(7), Pg. 53, 1984.

4-Hydroxybenzoic acid Safety Profile

Hazard Codes: IrritantXi
Risk Statements: 36-36/37/38 
R36:Irritating to eyes. 
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-37/39-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36:Wear suitable protective clothing. 
S37/39:Wear suitable gloves and eye/face protection.

4-Hydroxybenzoic acid Specification

 4-Hydroxybenzoic acid , its cas register number is 99-96-7. It also can be called 4-Hydroxybenzenecarboxylic acid ; Benzoic acid, 4-hydroxy- ; and 4-Hydroxy-benzoesaeure . It is hazardous, so the first aid measures and others should be known. Such as: When on the skin: first, should flush skin with plenty of water immediately for at least 15 minutes while removing contaminated clothing. Secondly, get medical aid. Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Then get medical aid soon. While, it's inhaled: Remove from exposure and move to fresh air immediately. Give artificial respiration while not breathing. When breathing is difficult, give oxygen. And as soon as to get medical aid. Then you have the ingesting of the product: Wash mouth out with water, and get medical aid immediately.
In addition, 4-Hydroxybenzoic acid (CAS NO.99-96-7) could be stable under normal temperatures and pressures. It is not compatible with strong oxidizing agents, and you must not take it with incompatible materials. And also prevent it to broken down into hazardous decomposition products: irritating and toxic fumes and gases. hydrogen chloride, carbon monoxide, carbon dioxide.

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