Basic information
- Name:
Chlorpheniramine maleate
- CAS No.:
113-92-8
- Molecular Structure:
- Formula:
- C20H23ClN2O4
- Molecular Weight:
- 390.86
- Deleted CAS:
- 7054-11-7
- Synonyms:
- 2-Pyridinepropanamine,?-(4-chlorophenyl)-N,N-dimethyl- [132-22-9] but the (Z)-2-butenedioate (1:1);Prestwick_57;Allergin;Chlor-trimeton;Teldrin;Piriton;Chlorprophenpyridamine;but-2-enedioic acid; 3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-yl-propan-1-amine;Chlorpheniramine maleate (JP14/USP);[3-(4-chlorophenyl)-3-pyridin-2-yl-propyl]-dimethyl-azanium; (Z)-4-hydroxy-4-oxo-but-2-enoate;Chlor-Tripolon;Neorestamin;Chlor-trimeton (TN);2-Pyridinepropanamine,?-(4-chlorophenyl)-N,- N-dimethyl-,(2Z)-2-butenedioate (1:1);chlorphenamine hydrogen maleate;Teldrin (TN);
- EINECS:
- 204-037-5
- Density:
- 1.107 g/cm3
- Melting Point:
- 130-135 ºC
- Boiling Point:
- 379 ºC at 760 mmHg
- Flash Point:
- 183 ºC
- Solubility:
- 1-5 g/100 mL at 21 ºC
- Hazard Symbols:
T- Risk Codes:
- 25
- Safety Description:
- 36/37/39-45 Details
- Transport Information:
- UN 2811 6.1/PG 3
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Chemistry
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IUPAC Name: (Z)-But-2-enedioic acid; 3-(4-Chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine
Molecular Formula: C20H23ClN2O4
Molecular Weight: 390.86 g/mol
Canonical SMILES: c1([C@@H](c2ccccn2)CCN(C)C)ccc(Cl)cc1.C(=C\C(O)=O)\C(O)=O
InChI: InChI=1/C16H19ClN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
EINECS: 204-037-5
Classification Code: Antihistaminic; Drug / Therapeutic Agent; Mutation data; Reproductive Effect; Tumor data
Product Categories: Intermediates & Fine Chemicals; Pharmaceuticals; Antagonists; Histaminergics; Neurotransmitters
Index of Refraction: 1.565
Molar Refractivity: 80.8 cm3
Molar Volume: 248 cm3
Polarizability: 32.03×10-24 cm3
Surface Tension: 42.1 dyne/cm
Density: 1.107 g/cm3
Flash Point: 183 °C
Enthalpy of Vaporization: 62.7 kJ/mol
Boiling Point: 379 °C at 760 mmHg
Melting Point: 130-135 °C(lit.)
Water Solubility: 1-5 g/100 mL at 21 °C
Vapour Pressure of Chlorpheniramine maleate (CAS NO.113-92-8): 6.04E-06 mmHg at 25 °C
Uses
Chlorpheniramine maleate (CAS NO.113-92-8) is used as antihistaminic.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| bird - wild | LD50 | oral | 75mg/kg (75mg/kg) | Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972. | |
| dog | LD50 | intravenous | 97600ug/kg (97.6mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Journal of Pharmacology and Experimental Therapeutics. Vol. 113, Pg. 72, 1955. |
| guinea pig | LD50 | intravenous | 68mg/kg (68mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 113, Pg. 313, 1958. | |
| guinea pig | LD50 | oral | 198mg/kg (198mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Journal of Pharmacology and Experimental Therapeutics. Vol. 113, Pg. 72, 1955. |
| guinea pig | LD50 | subcutaneous | 101mg/kg (101mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Journal of Pharmacology and Experimental Therapeutics. Vol. 113, Pg. 72, 1955. |
| mouse | LD50 | intraperitoneal | 76700ug/kg (76.7mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT | Journal of Pharmacology and Experimental Therapeutics. Vol. 113, Pg. 72, 1955. |
| mouse | LD50 | intravenous | 26100ug/kg (26.1mg/kg) | Toxicology and Applied Pharmacology. Vol. 23, Pg. 537, 1972. | |
| mouse | LD50 | oral | 130mg/kg (130mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 1644, 1978. | |
| mouse | LD50 | subcutaneous | 104mg/kg (104mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT | Journal of Pharmacology and Experimental Therapeutics. Vol. 113, Pg. 72, 1955. |
| rat | LD50 | oral | 306mg/kg (306mg/kg) | SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT | Kiso to Rinsho. Clinical Report. Vol. 12, Pg. 1371, 1978. |
| rat | LD50 | subcutaneous | 365mg/kg (365mg/kg) | Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971. |
Safety Profile
Poison by ingestion, intravenous, and subcutaneous routes. Experimental reproductive effects. Used as an antihistamine. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cl− and NOx.
Hazard Codes: 
T
Risk Statements: 25
R25: Toxic if swallowed.
Safety Statements: 36/37/39-45
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: US6504000
HazardClass: 6.1(b)
PackingGroup of Chlorpheniramine maleate (CAS NO.113-92-8): III
Specification
Chlorpheniramine maleate (CAS NO.113-92-8), its Synonyms are Anaplex HD ; Azimycin (Veterinary) ; Bayer Select Allergy-Sinus ; Bayer Select Flu Relief ; Brexin L.A. ; Cerose-DM ; Chlor-Trimeton Decongestant ; Chlor-Trimeton Sinus ; Sudafed Plus ; Teldrin Timed-Release Allergy Capsules ; TheraFlu ; Triaminic ; 1-(N,N-Dimethylamino)-3-(p-chlorophenyl-3-alpha-pyridyl)propane maleate ; 1-(p-Chlorphenyl)-1-(2-pyridyl)-3-dimethylaminopropan maleat ; dl-Chlorpheniramine maleate . It is odorless white crystalline solid or white powder with a bitter taste.