Basic information
- Name:
Hydrocortisone acetate
- CAS No.:
50-03-3
- Molecular Structure:
- Formula:
- C23H32O6
- Molecular Weight:
- 404.50 .
- Synonyms:
- Cortacream;Cortaid;Cortef acetate;Cortell;Corticaine;Cortifoam;Cortril acetate;Cortril acetate AS;Efcolin;HA;Hc 45;Hycortole acetate;Hydrocort acetate;Hydrocortisat;Hydrocortisone 21-acetate;Cortisolacetate (6CI);Cortisol, 21-acetate (7CI,8CI);11b,17a,21-Trihydroxypregn-4-ene-3,20-dione21-acetate;17-Hydroxycorticosterone 21-acetate;17a-Hydroxycorticosterone acetate;21-Acetoxy-11b,17-dihydroxypregn-4-en-3,20-dione;21-Acetoxy-11b,17-dihydroxypregn-4-ene-3,20-dione;21-Acetoxy-11b,17a-dihydroxypregn-4-ene-3,20-dione;Abbocort;Anusol HC;Bambicort;Berlison F;Biocortar;CaldeCort;Chemysone;Colifoam;Colofoam;Cordes;
- EINECS:
- 200-004-4
- Density:
- 1.26 g/cm/3
- Melting Point:
- 223 °C (dec.)(lit.)
- Boiling Point:
- 576.6 °C at 760 mmHg
- Flash Point:
- 196.2 °C
- Appearance:
- white powder
- Hazard Symbols:
Xn- Risk Codes:
- 63
- Safety Description:
- 36/37 Details
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Chemistry
The Molecular Structure of Hydrocortisone acetate (CAS NO.50-03-3):
Empirical Formula: C23H32O6
Molecular Weight: 404.4966
Appearance: white powder
Nominal Mass: 404 Da
Average Mass: 404.4966 Da
Monoisotopic Mass: 404.219889 Da
Index of Refraction: 1.572
Molar Refractivity: 105.15 cm3
Molar Volume: 319.2 cm3
Surface Tension: 54.6 dyne/cm
Density: 1.26 g/cm3
Flash Point: 196.2 °C
Enthalpy of Vaporization: 99.14 kJ/mol
Boiling Point: 576.6 °C at 760 mmHg
Vapour Pressure: 1.08E-15 mmHg at 25°C
Storage temp: 0-6°C
Decomposition: 223°C
IUPAC Name: [2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
Stability: Stable, but may be light or moisture sensitive. Incompatible with strong oxidizing agents.
Product Categories: Biochemistry;Hydroxyketosteroids;Steroids;Intermediates & Fine Chemicals;Pharmaceuticals;Veterinaries
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 2300mg/kg (2300mg/kg) | Compilation of LD50 Values of New Drugs. | |
| mouse | LD50 | subcutaneous | 45050ug/kg (45.05mg/kg) | National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986, | |
| rat | LDLo | subcutaneous | 250mg/kg (250mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 27, Pg. 2102, 1977. |
RTECS : GM8960000
Safety Profile
Hazard Codes: 
Xn
Risk Statements: 63
R63: Possible risk of harm to the unborn child
Safety Statements: 36/37
S36/37: Wear suitable protective clothing and gloves
WGK Germany: 3
Specification
Hydrocortisone acetate (CAS NO.50-03-3) can be also called as (11Beta)-21-(acetoxy)-11,17,21-trihydroxypregna-1,4-diene-3,20-dione ; 11,17-Dihydroxy-3,20-dioxopregn-4-en-21-yl acetate ; 11-Beta,17-alpha-dihydroxy-21-acetoxypregesterone ; 11Beta17alpha-dihydroxy-21-acetoxypregesterone ; 17-Alpha-hydrocorticosterone21-acetate ; 17Alpha-hydrocorticosterone-21-acetate ; 17-Dihydroxy-20-dion(11-beta)-pregn-4-ene-21-(acetoxy)-11 ; 17-Dihydroxy-20-dion(11beta)-pregn-4-ene-21-(acetyloxy)-11 .