Reference

Chromatographic studies on the stability of some antibiotic ointments

Chromatographic studies on the stability of some antibiotic ointments. Verbuta, Aneta; Marinescu, Paraschiva (Inst. Med. Farm., Iasi, Rom.). Rev. Med.-Chir., 86(3), 481-3 (Romanian) 1982. CODEN: RMNIBN. ISSN: 0300-8738. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 64 The stability of K benzylpenicillin (I) [113-98-4], tetracycline-HCl (II) [64-75-5], chloramphenicol (III) [56-75-7], and erythromycin (IV) [114-07-8] in the ointment bases, bentonite glycerogel (V) and Novadeps U (VI) were investigated by TLC at 3, 7, 30, 60, and 75 days. I was stable for 8 days in V after which the b-lactam nuclei is cleaved, whereas in VI it was stable for 76 days. II was found in fresh prepns. of V together with its epimers, 4-epitetracycline, anhydrotetracycline and 4-epianhydrotetracycline 14 days after prepn., and with only 4-epitetracycline in fresh prepns. of VI for the next 75 days. III was stable for 30 days in V and for 87 days in VI. IV showed a single spot in both ointment bases.

Kinetics of the mass crystallization of benzylpenicillin salts in water-butanol solutions

Kinetics of the mass crystallization of benzylpenicillin salts in water-butanol solutions. Popova, M. V. (USSR). Zh. Prikl. Khim. (Leningrad), 56(12), 2673-7 (Russian) 1983. CODEN: ZPKHAB. ISSN: 0044-4618. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Exptl. data on the crystn. of K benzylpenicillin [113-98-4] by evapn. from its BuOH [71-36-3]-H2O solns. and Na benzylpenicillin [69-57-8] by salting out from the same solvent mixt. are expressed by the equation Kp1 = f(Zg), which described the dependence of change of cryst.In this experiment, several chemicals are used like 69-57-8 and 7732-18-5 state on the relative time of process of crystn. The equation is general and can be used for mass crystn. .