- Skin aging inhibitor
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PROBLEM TO BE SOLVED: To provide a skin aging inhibitor. SOLUTION: A skin aging inhibitor contains, as an active ingredient, at least one compound selected from a hydroxy benzoic acid represented by formula (1) and a derivative thereof [in the formula R1 is hydrogen, a methyl group or a glucosyl group; in the formula R2 is a group selected from the group consisting of hydrogen, a C1-8 linear or branched hydrocarbon group, an aromatic hydrocarbon group, and a sugar residue of glucose or sorbitol] and a salt thereof. SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT
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Paragraph 0048
(2018/09/22)
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- Tyrosinase-like reactivity in a CuIII2(??-O) 2 species
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A study was conducted to demonstrate a bis(??-oxo)dicopper(III) species that binds and ortho-hydroxylates phenolates for reactivity of tyrosinase. The study characterized a metastable species from the low-temperature reaction of sodium p-chloro-phenolate (p-Cl-C6H4ONa) with a bis(??-oxo)dicopper(III) species. The study found that the addition of 10 equivalents of the sodium salt of p-chlorophenol at -90?°C can cause bleaching of the spectral features. High performance liquid chromatography (HPLC) analysis showed that 4-chlorocatechol was formed in 76% yield. The study used UV/UVis monitoring for reaction in acetone to determine the initial features to the bis(??-oxo) species and found that these features disappear after phenolate addition. The study observed that the activation parameters for the monophenolase reaction catalyzed by tyrosinase.
- Company, Anna,Palavicini, Sara,Garcia-Bosch, Isaac,Mas-Ballesteì?, Ruben,Que Jr., Lawrence,Rybak-Akimova, Elena V.,Casella, Luigi,Ribas, Xavi,Costas, Miquel
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supporting information; experimental part
p. 3535 - 3538
(2009/05/07)
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- Mechanisms of Nucleophilic Attack at Carbon-Nitrogen Double Bonds. The Reaction of Aryl N-Arylbenzimidates with Methoxide Ion
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Rate data for the reaction of three series of aryl N-arylbenzimidates with methoxide ion at 303 K are presented.Linear Hammett plots were obtained for each series.Solvent isotope effects have also been measured.The results are interpreted in terms of rate-determining formation of a tetrahedral intermediate, irrespective of the nature of the substituent.
- Rowe, Jeffrey E.
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p. 1259 - 1262
(2007/10/02)
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- Process for the preparation of alkali metal salts of hydroxybenzoates, which are substantially anhydrous and free from hydroxybenzoic acid
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Alkali metal salts of hydroxybenzoates are claimed which are substantially anhydrous and free from hydrobenzoic acid and have the formula STR1 in which R1 denotes alkyl, alkenyl, cycloalkyl or aralkyl, R2 and R3 are identical or different and represent hydrogen, halogen, hydroxyl, amino, alkylamino, alkyl, alkoxy, aralkyl or aryl and Me denotes an alkali metal. Furthermore a process for the preparation of the said alkali metal salts of hydroxybenzoates, which are substantially anhydrous and free from hydrobenzoic acid, characterized in that a solution or suspension of a hydroxybenzoate of the formula STR2 in which R1, R2 and R3 have the abovementioned meaning, is neutralized with an alkali metal hydroxide at -10° to +50° C. until the degree of neutralization is 0.95 to 1.05, a degree of neutralization of 1.00 denoting the end point of the neutralization of the phenolic OH group by the alkali metal hydroxide, and the resulting solution or suspension of the alkali metal salt of the hydroxybenzoate is passed to a mild drying operation which does not damage the product and is in itself known, after a time such that the content of hydroxybenzoic acid or the alkali metal salt thereof in this solution or suspension does not reach the value of 1% by weight, relative to the amount of alkali metal salt of hydroxybenzoate contained in this solution or suspension.
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