528-44-9

Basic information

• Product Name: Trimellitic acid
• Synonyms: 1,2,4-Tricarboxybenzene;1,3,4-Benzenetricarboxylic acid;1,4,5-Benzenetricarboxylic acid;4-Carboxyphthalic acid;F-TMA;NSC 72986;Trimellitic acid;1,2,4-Benzenetricarboxylic acid
• CAS NO: 528-44-9
• Molecular Formula: C₉H₆O₆
• Molecular Weight: 210.14034
• EINECS: 208-432-3
• Mol File: 528-44-9.mol

Chemical Properties

• Melting Point: 229-231℃
• Boiling Point: 505.51 °C at 760 mmHg
• Flash Point: 273.614 °C
• Appearance: white crystalline powder
• Density: 1.654 g/cm³
• Vapor Pressure: 4.85E-11mmHg at 25°C
• Water Solubility: 2.1 g/100 mL (25℃)
• CAS DataBase Reference: Trimellitic acid(CAS DataBase Reference)
• NIST Chemistry Reference: Trimellitic acid(528-44-9)
• EPA Substance Registry System: Trimellitic acid(528-44-9)

Safety Data

• Hazard Codes: Xi:Irritant
• Statements: R36/37/38:
• Safety Statements: S26:; S37/39:
• Hazardous Substances Data: 528-44-9(Hazardous Substances Data)

Usage

Uses

Used in Polymer Production:
Trimellitic acid is used as a monomer in the production of polyester resins and polyamides, contributing to the formation of high-performance polymers with enhanced properties.
Used in Corrosion Inhibition:
As a corrosion inhibitor, trimellitic acid is employed to protect materials from degradation caused by chemical or electrochemical reactions, thereby extending the service life of various industrial components.
Used as a Plasticizer:
Trimellitic acid functions as a plasticizer, enhancing the flexibility and workability of materials in applications such as the manufacturing of plastics and rubber products.
Used in Pharmaceutical Production:
Trimellitic acid serves as a precursor in the synthesis of pharmaceuticals, playing a crucial role in the development of new drugs and medicinal compounds.
Used in Dye Production:
In the dye industry, trimellitic acid is utilized as a precursor for the production of various dyes, contributing to the creation of a wide range of colorants for different applications.

InChI:InChI=1/C9H6O6/c10-7(11)4-1-2-5(8(12)13)6(3-4)9(14)15/h1-3H,(H,10,11)(H,12,13)(H,14,15)/p-3

Synthetic route

2.6-dimethylnaphthalene (581-42-0) → 2,6-Naphthalenedicarboxylic acid (1141-38-4) + 1,2,4-benzene tricarboxylic acid (528-44-9)

Conditions	Yield
With oxygen; complex catalyst comprising 6.21 wtpercent Co, 1.58 wtpercent Mn, 3.87 wtpercent Br In water; acetic acid at 200℃; under 14711.4 Torr; Product distribution / selectivity;	A 99.41% B n/a
With oxygen; complex catalyst comprising 5.0 wtpercent Co, 1.0 wtpercent Mn, 3.87 wtpercent Br In water; acetic acid at 200℃; under 14711.4 Torr; Product distribution / selectivity;	A 99.02% B n/a

1,2,4-Trimethylbenzene (95-63-6) → 1,2,4-benzene tricarboxylic acid (528-44-9)

Conditions	Yield
With air; acetic acid; 1N,3N,5N-trihydroxy-1,3,5-triazin-2,4,6[1H,3H,5H]-trione; cobalt(II) acetate; zirconyl acetate at 150℃; under 15200 Torr; for 6h;	97%
With 7H2O*3H3N*3H(1+)*[FeMo6O18(OH)6](3-); sodium carbonate; acetic acid at 100℃; under 750.075 Torr; for 12h; Reagent/catalyst; Temperature; Inert atmosphere;	97%
With cobalt(II) acetate; manganese(II) acetate; acetic acid at 110 - 220℃; under 14251.4 - 16501.7 Torr; Pressure; Temperature;	96.32%

2-cyano-1,4-benzenedicarboxylic acid → 1,2,4-benzene tricarboxylic acid (528-44-9)

Conditions	Yield
With water; sodium hydroxide at 115℃; for 5h;	96%
With potassium hydroxide

3,4-dimethylbenzoic acid (619-04-5) → 1,2,4-benzene tricarboxylic acid (528-44-9)

Conditions	Yield
Stage #1: 3,4-dimethylbenzoic acid With ferric(III) bromide; manganese(II) bromide tetrahydrate; water; hydrogen bromide; oxygen at 220℃; under 7500.75 - 24002.4 Torr; Inert atmosphere; Stage #2: With bromine In water under 21752.2 Torr;	93%
With N-hydroxyphthalimide; oxygen; cobalt(II) acetate; manganese (II) acetate tetrahydrate In acetic acid at 120℃; under 760.051 Torr; for 14h;	90%

2,4-dimethyl-benzoic acid (611-01-8) → 1,2,4-benzene tricarboxylic acid (528-44-9)

Conditions	Yield
Stage #1: 2,4-dimethyl-benzoic acid With air at 220℃; under 24002.4 Torr; Stage #2: With air at 220℃; under 21752.2 Torr;	92.3%
With nitric acid

2,4-dimethylbenzaldehyde (15764-16-6) → 1,2,4-benzene tricarboxylic acid (528-44-9)

Conditions	Yield
Stage #1: 2,4-dimethylbenzaldehyde With air at 220℃; under 24002.4 Torr; Stage #2: With air at 220℃; under 21752.2 Torr;	92%
Stage #1: 2,4-dimethylbenzaldehyde With air at 220℃; under 24002.4 Torr; Stage #2: With air at 220℃; under 21752.2 Torr;	92.1%
Stage #1: 2,4-dimethylbenzaldehyde With air at 220℃; under 24002.4 Torr; Stage #2: With air at 220℃; under 21752.2 Torr;	92.2%

3,4-dimethylbenzaldehyde (5973-71-7) → 1,2,4-benzene tricarboxylic acid (528-44-9)

Conditions	Yield
Stage #1: 3,4-dimethylbenzaldehyde With ferric(III) bromide; manganese(II) bromide tetrahydrate; water; hydrogen bromide; oxygen at 220℃; under 7500.75 - 24002.4 Torr; Inert atmosphere; Stage #2: With bromine In water under 21752.2 Torr; Product distribution / selectivity;	92%

benzene-1,2,4-tricarboxylic acid trimethyl ester (2459-10-1) → 1,2,4-benzene tricarboxylic acid (528-44-9)

Conditions	Yield
With water; sodium hydroxide In methanol at 70℃; for 48h; Temperature;	90.16%

1,2,4-Trimethylbenzene (95-63-6) → isophthalic acid (121-91-5) + terephthalic acid (100-21-0) + 1,2,4-benzene tricarboxylic acid (528-44-9)

Conditions	Yield
With oxygen; titanium(IV) isopropylate; tetrabutoxytitanium; manganese(II) acetate; cobalt(II) acetate; ammonium bromide; cerous nitrate In water; acetic acid at 150 - 225℃; under 5250.53 - 18751.9 Torr; for 1.2 - 1.25h; Product distribution / selectivity;	A n/a B n/a C 88.3%

2,6-diisopropylnaphthalene (24157-81-1) → 2,6-Naphthalenedicarboxylic acid (1141-38-4) + 1,2,4-benzene tricarboxylic acid (528-44-9)

Conditions	Yield
With manganese; hydrogen bromide; potassium acetate; cobalt; acetic acid at 169.84℃; under 15001.5 Torr; Concentration; Temperature; Reagent/catalyst; Inert atmosphere;	A 75.7% B 15.5%

1,2,4-Trimethylbenzene (95-63-6) + 2,4-dimethyl-benzoic acid (611-01-8) → 1,2,4-benzene tricarboxylic acid (528-44-9)

Conditions	Yield
Stage #1: 1,2,4-Trimethylbenzene; 2,4-dimethyl-benzoic acid With oxygen; cobalt(II) acetate In water at 120℃; under 3000.3 Torr; for 0.833333h; Stage #2: copper naphthenate; cobalt naphthenate at 170℃; under 3000.3 Torr; for 2h; Stage #3: With oxygen; manganese(II) bromide; hydrogen bromide at 220℃; under 24752.5 Torr; for 1.5h; Conversion of starting material;	66.6%
Stage #1: 1,2,4-Trimethylbenzene; 2,4-dimethyl-benzoic acid With oxygen; cobalt(II) acetate In water at 120℃; under 3000.3 Torr; for 0.833333h; Stage #2: copper naphthenate; magnesium naphthenate at 170℃; under 3000.3 Torr; for 2h; Stage #3: With oxygen; manganese(II) bromide; hydrogen bromide at 220℃; under 24752.5 Torr; for 1.5h; Conversion of starting material;	48.6%

1,2,4-Trimethylbenzene (95-63-6) → isophthalic acid (121-91-5) + terephthalic acid (100-21-0) + 1,2,4-benzene tricarboxylic acid (528-44-9) + benzene-1,2-dicarboxylic acid (88-99-3)

Conditions	Yield
With sodium hydroxide; water; dihydrogen peroxide; manganese(II) bromide at 380℃; under 172517 Torr;	A n/a B n/a C 50% D n/a

methyl coumalate (6018-41-3) + acetylenedicarboxylic acid diethyl ester (762-21-0) → 1,2,4-benzene tricarboxylic acid (528-44-9)

Conditions	Yield
at 155℃; Destillieren des Reaktionsprodukts im Vakuum und Verseifen mit methylalkoh.KOH;
at 155℃; Erwaermen des Reaktionsprodukts mit methanol. Kalilauge;

1,2,4-triisopropylbenzene (948-32-3) → 1,2,4-benzene tricarboxylic acid (528-44-9)

Conditions	Yield
With nitric acid

2-methylterephthalic acid (5156-01-4) → isophthalic acid (121-91-5) + 1,2,4-benzene tricarboxylic acid (528-44-9)

Conditions	Yield
With alkaline potassium permanganate

2-methylterephthalic acid (5156-01-4) → 1,2,4-benzene tricarboxylic acid (528-44-9)

Conditions	Yield
With potassium permanganate

4-sulfophthalic acid (89-08-7) + sodium formate (141-53-7) → isophthalic acid (121-91-5) + 1,2,4-benzene tricarboxylic acid (528-44-9)

Conditions	Yield
Reaktion des Kaliumsalzes, Schmelzen;

2,5-dimethylbenzyl chloride (824-45-3) → 1,2,4-benzene tricarboxylic acid (528-44-9)

Conditions	Yield
With potassium permanganate

1,2,3,4-tetrahydro-2-naphthoic acid (1131-63-1) → 1,2,4-benzene tricarboxylic acid (528-44-9)

Conditions	Yield
With potassium permanganate
With nitric acid at 140℃; im Rohr;

2,6-dimethyl-1,4-naphthoquinone (6290-94-4) → 1,2,4-benzene tricarboxylic acid (528-44-9)

Conditions	Yield
With potassium permanganate; water

indan-5-carboxylic acid (65898-38-6) → 1,2,4-benzene tricarboxylic acid (528-44-9)

Conditions	Yield
With alkaline permanganate
With nitric acid at 140℃; im Rohr;

4-(tert-butyl)-2-methylbenzoic acid (33691-85-9) → 1,2,4-benzene tricarboxylic acid (528-44-9)

Conditions	Yield
With nitric acid at 240℃;

4-cyano-phthalic acid diethyl ester (105903-40-0) → 1,2,4-benzene tricarboxylic acid (528-44-9)

Conditions	Yield
With sodium hydroxide

3-(2-ethyl-butyryl)-[2]naphthoic acid → 1,2,4-benzene tricarboxylic acid (528-44-9)

Conditions	Yield
With nitric acid at 120 - 140℃; im Rohr;

2,4-bis-trichloromethyl-benzoyl chloride (622367-70-8) → 1,2,4-benzene tricarboxylic acid (528-44-9)

Conditions	Yield
With water; calcium carbonate

biphenyl-2,4,3'-tricarboxylic acid → isophthalic acid (121-91-5) + 1,2,4-benzene tricarboxylic acid (528-44-9)

Conditions	Yield
bei der Oxydation;

4,4'-carbonyl-di-isophthalic acid (101439-06-9) → isophthalic acid (121-91-5) + 1,2,4-benzene tricarboxylic acid (528-44-9)

Conditions	Yield
at 280 - 285℃; bei der Kalischmelze;

propargyl alcohol (107-19-7) → benzene-1,3,5-tricarboxylic acid (554-95-0) + 1,2,4-benzene tricarboxylic acid (528-44-9)

Conditions	Yield
With bis(triphenylphosphine)nickel(0) dicarbonyl; benzene Erwaermen des Reaktionsprodukts mit wss. Salpetersaeure;

ethylbenzene (100-41-4) + 1,2-dichloro-ethane (107-06-2) → benzene-1,3,5-tricarboxylic acid (554-95-0) + 1,2,4-benzene tricarboxylic acid (528-44-9)

Conditions	Yield
With aluminium trichloride Erhitzen des Reaktionsprodukts mit HNO3 auf 180grad;
With aluminium trichloride Erwaermen des Reaktionsprodukts mit HNO3 auf 180grad;

methanol (67-56-1) + 1,2,4-benzene tricarboxylic acid (528-44-9) → benzene-1,2,4-tricarboxylic acid trimethyl ester (2459-10-1)

Conditions	Yield
With boron trifluoride at 65℃; for 0.333333h;	100%
With sulfuric acid
With hydrogenchloride
With sulfuric acid

1,2,4-benzene tricarboxylic acid (528-44-9) → ammonium trimellitate (7572-36-3, 78759-00-9, 123368-95-6, 123368-96-7)

Conditions	Yield
With ammonia In water for 1.5h; Heating;	99.7%

zirconyl(IV) nitrate hydrate + 1,2,4-benzene tricarboxylic acid (528-44-9) + benzoic acid (65-85-0) → [Zr6O4(OH)4(1,4-benzenedicarboxylate-CO2H)6]·2.0(1,4-benzenedicarboxylic acid-CO2H)

Conditions	Yield
In N,N-dimethyl-formamide at 150℃; for 24h;	95%

1,2,4-benzene tricarboxylic acid (528-44-9) + water (7732-18-5) + zinc(II) acetate dihydrate (5970-45-6) + N,N’-di(3-pyridyl)adipoamide (39642-63-2) → [Zn3(1,2,4-benzenetricarboxylate)2(N,N′-di(3-pyridyl)adipoamide)(H2O)4]·4H2O

Conditions	Yield
at 120℃; for 48h; Autoclave; High pressure;	95%

2-Ethylhexyl alcohol (104-76-7) + 1,2,4-benzene tricarboxylic acid (528-44-9) → Hatcol 200 (3319-31-1)

Conditions	Yield
With triflic acid on silica-encapsulated superparamagnetic iron oxide nanoparticles In neat (no solvent) at 90℃; for 0.416667h; Catalytic behavior; Time; Reagent/catalyst; Flow reactor; Green chemistry;	95%

1,2,4-benzene tricarboxylic acid (528-44-9) + butan-1-ol (71-36-3) → tris(n-butyl) trimellitate (1726-23-4)

Conditions	Yield
With triflic acid on silica-encapsulated superparamagnetic iron oxide nanoparticles In neat (no solvent) at 90℃; for 1.33333h; Catalytic behavior; Time; Reagent/catalyst; Flow reactor; Green chemistry;	92%
With microporous aluminosilicates zeolite HBeta In toluene at 117℃; for 5h; Dean-Stark;

1,2,4-benzene tricarboxylic acid (528-44-9) → [Li11(H3O)(H2O)5(1,2,4-benzenetricarboxylic acid(-2H))6]

Conditions	Yield
With 1,4-dioxane; water In methanol; water at 80℃; for 24h;	90%

1,2,4-benzene tricarboxylic acid (528-44-9) + 4′-(4-carboxyphenyl)-3,2′:6′,3″-terpyridine (1415258-35-3) + zinc(II) acetate dihydrate (5970-45-6) → [Zn2(4′-(4-carboxyphenyl)-3,2′:6′,3″-terpyridine(-1H))(1,2,4-benzenetricarboxylic acid(-3H))]n

Conditions	Yield
With sodium hydroxide In water at 180℃; for 72h; pH=5; Sealed tube;	89%

2,4,6-triamino-s-triazine (108-78-1) + 1,2,4-benzene tricarboxylic acid (528-44-9) → C9H6O6*C3H6N6

Conditions	Yield
In water at 120℃; for 2h; Autoclave;	85%

[2,2]bipyridinyl (366-18-7) + 1,2,4-benzene tricarboxylic acid (528-44-9) + water (7732-18-5) + cobalt(II) diacetate tetrahydrate (6147-53-1) → Co3(C5H4N)4(C6H3(COO)3)2(H2O)2 (347412-36-6)

Conditions	Yield
In water High Pressure; heated at a rate of 20°C/h to 230°C; maintaining at this temp. for 2 h; cooling at a rate of 5°C/h to 180°C; cooled at 2°C/h to 90°C; cooled to 50°C at 4°C/h; cooled to room temp. (5°C/h); elem.anal.;	81%

[2,2]bipyridinyl (366-18-7) + 1,2,4-benzene tricarboxylic acid (528-44-9) + water (7732-18-5) + manganese (II) acetate tetrahydrate (6156-78-1) → Mn3(C5H4N)4(C6H3(COO)3)2(H2O)2 (347412-37-7)

Conditions	Yield
In water High Pressure; heated at a rate of 20°C/h to 230°C; maintaining at this temp. for 2 h; cooling at a rate of 5°C/h to 180°C; cooled at 2°C/h to 90°C; cooled to 50°C at 4°C/h; cooled to room temp. (5°C/h); elem.anal.;	80%

pyridin-4-ol (626-64-2) + 1,2,4-benzene tricarboxylic acid (528-44-9) → 2C5H5NO*C9H6O6

Conditions	Yield
In dimethyl sulfoxide at 90℃;	80%

1,2,4-benzene tricarboxylic acid (528-44-9) → trimellitic acid amide-imide (21343-93-1)

Conditions	Yield
With urea at 250℃; for 2h;	80%

indium(III) nitrate pentahydrate + 1,2,4-benzene tricarboxylic acid (528-44-9) → [H3O][In2(1,2,4-benzenetricarboxylate)(1,4-benzenedicarboxylate)(OH)2]*5.5H2O

Conditions	Yield
With piperazine In water High Pressure; mixt. of In(NO3)3*5H2O, 1,2,4-benzenetricarboxylic acid, piperazine, H2Oplaced in autoclave, heated at 443 K for 3 d, cooled to room temp. at 1 0 K/h; washed with H2O, dried in air; elem. anal.;	78%

cadmium(II) nitrate tetrhydrate + 1,2,4-benzene tricarboxylic acid (528-44-9) + 3,2′:6′,3′′-terpyridine-4′-carboxylic acid (1214357-77-3) → [Cd4(3,2′:6′,3′′-terpyridine-4′-carboxylate)2(1,2,4-benzenetricarboxylate)2(H2O)2]*2H2O

Conditions	Yield
With sodium hydroxide In water at 180℃; for 72h; pH=5; High pressure; Autoclave;	77%

bismuth (III) nitrate pentahydrate + 1,2,4-benzene tricarboxylic acid (528-44-9) + water (7732-18-5) → Bi(Tri)(H2O)

Conditions	Yield
With nitric acid In water at 150℃; for 12h;	76.6%

1,2,4-benzene tricarboxylic acid (528-44-9) + diphenyl acetylene (501-65-5) → 5,6,7,8-tetraphenyl-1,3-naphthalenedicarboxylic acid

Conditions	Yield
With [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; tetrabutylammomium bromide; 5-methyl-dihydro-furan-2-one In N,N-dimethyl-formamide at 100℃; for 12h;	76%
With [ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; tetrabutylammomium bromide In N,N-dimethyl-formamide at 100℃; for 12h; Sealed tube;	76%

1,2,4-benzene tricarboxylic acid (528-44-9) + urea (57-13-6) + cobalt(II) chloride (7646-79-9) → (29H,31H-2,9,16,23-tetracarboxyphthalocyaninato-N(29),N(30),N(31),N(32))cobalt(II) (69934-86-7)

Conditions	Yield
With sodium sulfate; ammonium molybdate In further solvent(s) a mixt. in 1-bromonaphthalene was stirred for 4 h at 210-215°C, cooled; diluted with methanol, filtered, washed with methanol, CHCl3 and water, squeezed, dried, refluxed with 10 NaOH (6 h) and 10 HCl (1 h); elem. anal.;	75%

zinc(II) sulfate heptahydrate + 1,2,4-benzene tricarboxylic acid (528-44-9) + 1-(1H-imidazol-4-yl)-4-(4H-tetrazol-5-yl)benzene → [Zn3((1H-imidazol-4-yl)-4-(4H-tetrazol-5-yl-1-ido)benzene)3(1,2,4-benzenetricarboxylato)]

Conditions	Yield
In water; N,N-dimethyl-formamide at 180℃; for 72h; Autoclave;	75%

Upstream product

• 15764-16-6 2,4-dimethylbenzaldehyde 
• 6018-41-3 methyl coumalate 
• 762-21-0 acetylenedicarboxylic acid diethyl ester 
• 95-63-6 1,2,4-Trimethylbenzene 
• 948-32-3 1,2,4-triisopropylbenzene 
• 5156-01-4 2-methylterephthalic acid 
• 89-08-7 4-sulfophthalic acid 
• 141-53-7 sodium formate 
• 824-45-3 2,5-dimethylbenzyl chloride 
• 1131-63-1 1,2,3,4-tetrahydro-2-naphthoic acid 
• 6290-94-4 2,6-dimethyl-1,4-naphthoquinone 
• 65898-38-6 indan-5-carboxylic acid 
• 33691-85-9 4-(tert-butyl)-2-methylbenzoic acid 
• 105903-40-0 4-cyano-phthalic acid diethyl ester 

Downstream Products

• 2459-10-1 benzene-1,2,4-tricarboxylic acid trimethyl ester 
• 2902-64-9 4-methoxycarbonylphthalic anhydride 
• 29639-49-4 benzene-1,2,4-tricarboxylic acid-4-methyl ester 
• 185050-61-7 benzene-1,2,4-tricarboxylic acid-1,4-dimethyl ester 
• 14230-18-3 triethyl benzene-1,2,4-tricarboxylate 
• 20262-55-9 11,3-dioxoisoindoline-5-carboxylic acid 
• 121-91-5 isophthalic acid 
• 100-21-0 terephthalic acid 
• 552-30-7 trimellitic Anhydride 
• 76784-85-5 trimethyl r-1,c-2,t-4-cyclohexanetricarboxylate 
• 76784-85-5 trimethyl r-1,c-2,c-4-cyclohexanetricarboxylate 
• 7572-36-3 ammonium trimellitate 
• 21793-92-0 r-1,c-2,c-4-cyclohexanetricarboxylic acid 
• 92-52-4 biphenyl 

Relevant articles and documents

Kinetics and process parameter studies in highly selective air oxidation of side-chain alkyl groups in picolines, 2-methylnaphthalene, and pseudocumene

Picolines, 2-methylnaphthalene, and pseudocumene were oxidized by air in acetic acid medium. Process parameters and kinetics of the reaction were studied from the viewpoint of proces research and development. Use of lithium chloride as the promoter was worth considering for this oxidation to obtain a higher rate of reaction. At 170 °C and at a reactant concentration of 15% w/v, 52% conversion of β-picoline with a selectivity of 97% was achieved in 8 h.

Photo-induced deep aerobic oxidation of alkyl aromatics

Oxidation is a major chemical process to produce oxygenated chemicals in both nature and the chemical industry. Presently, the industrial manufacture of benzoic acids and benzene polycarboxylic acids (BPCAs) is mainly based on the deep oxidation of polyalkyl benzene, which is somewhat suffering from environmental and economical disadvantage due to the formation of ozone-depleting MeBr and corrosion hazards of production equipment. In this report, photo-induced deep aerobic oxidation of (poly)alkyl benzene to benzene (poly)carboxylic acids was developed. CeCl3 was proved to be an efficient HAT (hydrogen atom transfer) catalyst in the presence of alcohol as both hydrogen and electron shuttle. Dioxygen (O2) was found as a sole terminal oxidant. In most cases, pure products were easily isolated by simple filtration, implying large-scale implementation advantages. The reaction provides an ideal protocol to produce valuable fine chemicals from naturally abundant petroleum feedstocks. [Figure not available: see fulltext.].

PRODUCTION OF TRI-METHYL BENZENE DERIVATIVES

The present invention relates to the production of tri-functional aromatic molecules from diformylfuran, in particular to the production of tri-methyl benzene derivatives such as for example trimellitic acid or 1,2,4-tri(aminomethyl)benzene from diformylfuran and its derivatives.

Method for preparing trimellitic acid by means of catalytic oxidation of Anderson type heteropolyacid

The invention discloses a method for preparing trimellitic acid by means of catalytic oxidation of Anderson type heteropolyacid. The method comprises the following steps: enabling 1, 2, 4-trimethylbenzene, used as a raw material, to be subjected to an oxidation reaction in a solvent in action of a catalyst, an oxidizing agent and an additive; after the oxidation reaction is completed, carrying outaftertreatment to obtain trimellitic acid, wherein the catalyst is Anderson structure heteropolyacid, the additive is a weakly alkaline substance, the solvent is fatty carboxylic acid, the oxidationreaction temperature is 80-150 DEG C, the reaction gage pressure is 1.0-5.0MPa, and the reaction time is 1-24h. The catalyst adopted by the method has very high reaction activity and specific selectivity and can be recycled; hydrogen peroxide, air or oxygen is used as the oxidizing agent, so that the cost is lowered, the generation of three wastes can be reduced, and the method is environmentallyfriendly; the method is mild in reaction conditions, simple and convenient to operate and high in product yield, thus being suitable for industrial production.

A method of preparing 1,2,4,5-benzenetetracarboxylic acid or trimellitic acid from pinacol

The invention relates to a method of preparing 1,2,4,5-benzenetetracarboxylic acid or trimellitic acid from pinacol. The method includes a first step of selectively dehydrating the pinacol in an acid/ionic liquid catalytic system to generate 2,-3-dimethyl-1,3-butadiene; a second step of subjecting the 2,-3-dimethyl-1,3-butadiene and maleate or acrylate to a D-A cycloaddition/dehydrogenation tandemreaction to generate an aromatic ring product; and a third step of subjecting the aromatic ring product to hydrolysis and oxidation to prepare the 1,2,4,5-benzenetetracarboxylic acid or the trimellitic acid. The catalytic system adopted in the method is green, and can be recycled. The raw material is a biomass-based platform chemical, and is cheap and easily available. All reaction processes aresimple. The pinacol dehydration reaction, the dehydrogenation reaction of a D-A product and an oxidation reaction are high in activity and selectivity. The novel method for preparing the 1,2,4,5-benzenetetracarboxylic acid and the trimellitic acid which are fine chemicals from the pinacol that is a lignocelluloses based platform chemical is provided by the invention.

A trimellitic acid synthesis method (by machine translation)

The invention belongs to the technical field of organic chemical industry, in particular to a trimellitic acid synthesis method. In order to trimellitic anhydride as the starting material, by esterification reaction to produce 1, 2, 4 - benzene citric acid three-methyl ester, 1, 2, 4 - benzene citric acid three-methyl ester hydrolysis reaction to obtain the trimellitic acid. The method of the invention the operation is simple, mild reaction conditions, the use of the reagent is easy cheap, simple post-treatment, do not need column chromatography, easy monitoring of the end point of the reaction, the yield is higher, can realize industrial production. (by machine translation)

Method for synthesizing trioctyl trimellitate

The invention discloses a method for synthesizing trioctyl trimellitate, and relates to the technical field of polymers. The method includes the following steps: carrying out an oxidation reaction to obtain trimellitic acid, carrying out an esterification reaction on trimellitic acid and octanol to obtain trioctyl trimellitate, and carrying out extraction and purification on the trioctyl trimellitate to obtain the trioctyl trimellitate. The trioctyl trimellitate is synthesized from 1,2,4-trimethylbenzene through directly reacting the generated trimellitic acid with octanol without separation or purification in the stage for the oxidation preparation of 1,2,4-trimethylbenzene. The method for synthesizing trioctyl trimellitate through a one-step process has the advantages of reduction of synthesis steps, avoiding of the use of trimellitic anhydride with high price and high corrosion, and significant reduction of the synthesis cost of the trioctyl trimellitate.

Sustainable production of pyromellitic acid with pinacol and diethyl maleate

Herein, we report an unprecedented and sustainable route to synthesize pyromellitic acid (PMA), a monomer of polyimide, with pinacol and diethyl maleate which can be derived from lignocellulose. Analogously, a sustainable route to trimellitic acid (TMA) was also developed using pinacol and acrylate as the feedstocks.

Continuous production method of trimellitic acid

The invention discloses a continuous production method of trimellitic acid. The method comprises the following processes of premixing, oxidation, coarse crystallization, filtration and recrystallization, which are sequentially performed, and comprises the following specific processes of (1) performing premixing: mixing raw materials namely unsym-trimethyl benzene, a solvent namely acetic acid, main catalysts namely cobalt acetate and manganese acetate, and a cocatalyst namely tetrabromoethane, and performing preheating to 60-120 DEG C, wherein the mass ratio of the unsym-trimethyl benzene to the acetic acid is 1 to (2-10); (2) performing oxidation: performing 2-4 continuous oxidation stages which are in series connection, and enabling the reaction temperature of the later oxidation stage to be higher than that of the previous oxidation stage; (3) performing coarse crystallization: performing coarse crystallization and then performing centrifugal separation; (4) performing filtration: dissolving crude trimellitic acid in water of 80-100 DEG C, controlling the percentage by mass of the trimellitic acid to be 15-35%, and filtering a hot solution when the solution is still hot; and (5) performing recrystallization: performing recrystallization and then performing centrifugal separation. According to the method disclosed by the invention, the trimellitic acid products with high conversion rate, high yield and high purity can be obtained.

Production Of Terephthalic Acid Via Reductive Coupling Of Propiolic Acid Or Propiolic Acid Derivatives

A method of making terephthalic acid via reductive coupling of two molecules of propiolic acid or propiolic acid derivatives is presented. The reductive coupling can be catalyzed by compounds comprising metals, and propiolic acid or propiolic acid derivatives can be produced from acetylene and carbon dioxide. At least 4 of the 8 carbons in the terephthalic acid are non-fossil-derived.