121998-76-3

Basic information

• Product Name: 2-phenyl-2,3-dihydro-4(1H)-quinazolinone
• CAS NO: 121998-76-3
• Molecular Weight: 224.262
• Mol File: 121998-76-3.mol

Chemical Properties

• CAS DataBase Reference: 2-phenyl-2,3-dihydro-4(1H)-quinazolinone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenyl-2,3-dihydro-4(1H)-quinazolinone(121998-76-3)
• EPA Substance Registry System: 2-phenyl-2,3-dihydro-4(1H)-quinazolinone(121998-76-3)

Safety Data

• Hazardous Substances Data: 121998-76-3(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 1885-29-6 anthranilic acid nitrile 
• 17762-72-0 2-phenyl-tetrahydro-(2H)-1,3-oxazine 
• 28144-70-9 anthranilic acid amide 
• 31230-83-8 2-Phenylbenzothiazolin 
• 16192-33-9 3-Methyl-2-phenyl-2,3-dihydrobenzothiazoline 
• 591-51-5 phenyllithium 
• 7455-91-6 3-(2'-cyanoethyl)-quinazolin-4-one 
• 20515-61-1 2-phenyl-4,4-dimethyloxazolidine 
• 610-15-1 2-nitrobenzamide 
• 118-48-9 isatoic anhydride 
• 491-36-1 4-Hydroxyquinazoline 
• 2783-66-6 1-methyl-2-phenylbenzothiazolium iodide 
• 703-59-3 homophthalic anhydride 

Downstream Products

• 1022-45-3 2-phenyl-4(3H)-quinazolinone 
• 80478-01-9 1,3-diacetyl-2-phenyl-1,2,3,4-tetrahydroquinazolin-4-one 
• 17119-69-6 toluene-d₂ 
• 1124-18-1 toluene-d3 
• 145471-16-5 C₁₅H₁₀N₄O 
• 145470-99-1 C₁₆H₁₂N₄ 
• 6483-99-4 2-phenyl-3,4-dihydroquinazolin-4-thione 
• 6484-29-3 C₁₄H₁₂N₄ 
• 6506-59-8 5-phenyl-1,2,4-triazolo<4,3-c>quinazoline 
• 6499-41-8 5-phenyltetrazolo<1,5-c>quinazoline 
• 19857-37-5 3-benzyl-2-phenyl-3,4-dihydroquinazolin-4-one 
• 939966-50-4 3-(4-methoxybenzyl)-2-phenyl-(3H)-quinazolin-4-one 
• 26060-02-6 2-phenyl-3-n-propylquinazoline-4(3H)-one 
• 67796-16-1 2-phenyl-3-n-butylquinazoline-4(3H)-one 

Relevant articles and documents

Supramolecular Fe3O4@PEG/?diaza crown ether@Ni: a novel magnetically reusable nano catalyst for the clean synthesis of 2-aryl-2,3-dihydroquinazolin-4(1H)-ones

Ni@diaza crown ether complex supported on magnetic nanoparticle was provided by grafting technique. The catalytic activity of Fe3O4@diaza crown ether@Ni was explored through one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones and it was used as an efficient and recoverably constant nanocatalyst. FT-IR, SEM, TEM, XRD, BET, ICP, EDS, and TGA techniques were employed to specify the nanocatalyst. This heterogeneous catalyst demonstrated acceptable recyclability and could be used again several times with no considerable loss of its catalytic activity.

Synthesis, characterization, and application of Fe3O4-SA-PPCA as a novel nanomagnetic reusable catalyst for the efficient synthesis of 2,3-dihydroquinazolin-4(1H)-ones and polyhydroquinolines

Piperidine-4-carboxylic acid (PPCA) functionalized Fe3O4 nanoparticles (Fe3O4-PPCA) were prepared by the one pot co-precipitation of iron oxide in the presence of PPCA. Grafting of chlorosulfonic acid on the synthesized Fe3O4-PPCA nanoparticles afforded sulfamic acid-functionalized magnetic nanoparticles (Fe3O4-SA-PPCA). The catalytic activity of Fe3O4-SA-PPCA as a novel catalyst was probed through one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones and polyhydroquinolines derivatives. The heterogeneous catalyst could be recovered easily and reused many times without significant loss of its catalytic activity.

The first report on the preparation of boehmite silica sulfuric acid and its applications in some multicomponent organic reactions

Boehmite silica sulfuric acid (boehmite-SSA) has been prepared for the first time via an efficient sequential synthetic procedure. Initially, boehmite nanoparticles were prepared, coated by silica, and then reacted with chlorosulfonic acid to obtain boehmite-SSA. A simple, inexpensive, environmentally friendly and efficient procedure for the synthesis of polyhydroquinoline and 2,3-dihydroquinazolin-4(1H)-one derivatives using this compound as an efficient and novel nanocatalyst has been described. Boehmite-SSA is a stable, heterogeneous, cost-effective, easy to handle, and recoverable catalyst and can be reused for several consecutive runs without a significant loss of catalytic activity. Its structure was characterized by FT-IR spectroscopy, thermogravimetric analysis (TGA), powder X-ray diffraction (XRD) and scanning electron microscopy (SEM).

One-pot, three-component synthesis of 2,3-dihydro-4(1H)-quinazolinones by montmorillonite K-10 as an efficient and reusable catalyst

A wide range of mono- and disubstituted dihydroquinazolinones were synthesised via condensation of isatoic anhydride, primary amines, or ammonium salts with aromatic aldehydes in the presence of montmorillonite K-10. The catalyst is reusable and could be recycled for several runs without any decrease in its efficiency. Copyright Taylor & Francis Group, LLC.

A new concise synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives

A new T3P-assisted, convenient and efficient procedure for the synthesis of dihydroquinazolinones is described. The main advantages of this protocol include its practical simplicity, short reaction times and particularly the ease with which products are isolated.

Scalable preparation, characterization, and application of alkali-treated starch as a new organic base catalyst

Preparation, characterization, and application of alkali starch (AS) given by dry co-grinding of starch and alkali is described in this work. Grinding using a mortar (agate) and pestle or, more conveniently, a ball mill has been found to be satisfactory for the preparation of the AS. The AS products were characterized by scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR) and x-ray fluorescence (XRF) analyses. The base capacities of ASs were 4.25–4.45 mmol/g, respectively. AS is a low cost and easy to handle base catalyst that showed promising catalytic performance in the synthesis of a dihydroquinazoline-based antibacterial drug that involves tandem hydration or decarboxylative amidation, imination, and Aza-Michael reactions.

Inclusion complex of Isatoic anhydride with β-cyclodextrin and supramolecular one-pot synthesis of 2, 3-dihydroquinazolin-4(1H)-ones in aqueous media

The inclusion complex of isatoic anhydride with β-cyclodextrin was formed as a result of intermolecular interaction between isatoic anhydride with β-CD. The inclusion complex was confirmed by IR spectroscopy, X-ray diffraction and DSC studies. From application of complex, herein we have described a simple and efficient protocol for synthesis of 2, 3-dihydroquinazoline-4(1H)-one derivatives by one pot condensation of isatoic anhydride, ammonium acetate or amine and aldehyde using β-CD as a supramolecular catalyst in aqueous media.

DABCO containing acidic poly(ionic liquid): An efficient catalyst for the one-pot preparation of 2,3-dihydroquinazoline-4(1H)-ones

1,4-Diazabicyclo[2.2.2]octane (DABCO) containing acidic poly(ionic liquid) (DAIL) has been prepared via condensation of 1,4-dichloro butane and DABCO, as an efficient acidic catalyst and has been applied in the one-pot preparation of 2,3-dihydroquinazolin

Sulfated polyborate: mild, efficient and eco-friendly catalyst for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones

Abstract: An efficient, inexpensive and recyclable sulfated polyborate catalyst was applied in a three-component, one-pot cyclocondensation of isatoic anhydride, aldehydes and ammonium acetate/amines to afford the corresponding 2,3-dihydroquinazolin-4(1H)-ones. The key advantages of the present method are high yields, short reaction time, easy workup, recyclability of catalyst and ability to tolerate a variety of functional groups which gives economical as well as ecological rewards. Graphical Abstract: [Figure not available: see fulltext.].

One-pot, three-component synthesis of 2,3-dihydroquinazolin-4(1H)-ones using p-Toluenesulfonic acid-paraformaldehyde copolymer as an efficient and reusable catalyst

p-Toluenesulfonic acid-paraformaldehyde copolymer (copolymer-PTSA) catalyzes the three-component, one-pot condensation reaction of isatoic anhydride, ammonium salts or aromaticand aliphatic amines, and aldehydes in refluxing ethanol. The catalyst is reusable and could be recycled for several runs without any decrease in its efficiency. Springer-Verlag 2010.