128-04-1Relevant articles and documents
Syntheses, crystal structures and non-linear optical responses of two new heteroselenometallic cluster compounds containing dithiocarbamate ligands
Zhang, Qian-Fcng
, p. 605 - 610 (2000)
Two novel dialkyldithiocarbamate-containing heteroselenometallic clusters, [NEt4]2[(WSe4)(Et2NCS 2Cu)3] 1 and [NEt4]2[(WSe4)(Me2NCS 2Cu)4] 2, have'been synthesized through reactions of [NEt4]2[WSe4] with CuCl and R2NCS2Na (R = Et or Me) in DMF. The [(WSe4)(Et2NCS2Cu)3]2- anion in 1 comprises three El2NCS2Cu fragments ligated by a slightly distorted tetrahedral VSe4 moiety. The [(WSe4)(Me2NCS2Cu)4]2- anion structure in 2 possesses a nearly planar WCu4 core and consists of four Me2NCS2Cu fragments co-ordinated across four edges of the tetrahedral [WSe4]2- moiety. The optical limiting effects of the two clusters were examined at a 0.5 Hz repetition rate. The thresholds of two samples were 6.0 and 1.1 J cm-1 for 1 and 2, respectively. The non-linear responses for the two clusters in DMF have also been studied in picosecond time-resolved pump-probe experiments. The Royal Society of Chemistry 2000.
Design, synthesis and pharmacological analysis of 5-[4′-(substituted-methyl)[1,1′-biphenyl]-2-yl]-1H-tetrazoles
Kamble, Atulkumar,Kamble, Ravindra,Dodamani, Suneel,Jalalpure, Sunil,Rasal, Vijaykumar,Kumbar, Mahadev,Joshi, Shrinivas,Dixit, Sheshagiri
, p. 444 - 457 (2017)
In the present paper 5-[4′-({4-[(4-aryloxy)methyl]-1H-1,2,3-triazol-1-yl}methyl)[1,1′-biphenyl]-2-yl]-1H-tetrazoles (5a–g) and [2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl-substituted-1-carbodithioates (11h–q) have been designed and synthesized. These compounds were subjected to docking (against AT1 receptor protein enzyme in complex with Lisinopril), in vitro angiotensin converting enzyme inhibition, anti-proliferative, anti-inflammatory screening (through egg albumin denaturation inhibition and red blood cell membrane stabilization assay) and finally anti-fungal activity analyses. Some of the compounds have shown significant pharmacological properties.
Facile synthesis of thiophene derivatives using a cyclopropenyl cation
Kojima, Hideo,Nakamura, Keiichi,Yamamoto, Kazuhiko,Inoue, Hiroo
, p. 1193 - 1195 (1996)
A novel convenient method for the synthesis of thiophene derivatives was developed using a tris(isopropylthio)cyclopropenyl cation, carbon disulfide, and the anions of secondary amines, 2-propanethiol, and ethanol.
Thiuram disulfide intercalated hybrid materials of layered lead and cadmium iodides
Ramalingam,Ilakkiya
, p. 734 - 739 (2016)
Thiuram disulfide intercalates of lead(II) and cadmium(II) were prepared by the reaction of binary layered metal iodides with five dithiocarbamates in air. The intercalates were characterized by elemental analysis, Powder X-ray diffraction (XRD), infrared (IR), ultraviolet-visible spectroscopy, diffuse reflectance spectroscopy, scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy, high-resolution transmission electron microscopy (HRTEM), and atomic force microscopy (AFM) techniques. IR showed increased contribution of the thioureide bond and the presence of weak disulfide stretching frequency. Powder XRD showed the characteristic intermediate 2θ signal confirming the intercalation. Powder XRD clearly differentiated intercalates from the iodinated product of dithiocarbamate. As the bulkiness of substituents on disulfide increased, "d" also increased. The higher thermal stability associated with intercalates clearly suggests a strong ionic interaction and a difficult de-intercalation. SEM images of lead intercalates indicated crystalline nature. The intercalates appeared as rods or spheres. The diallyl-intercalate, [PbI2](H5C3)2NCSS-SSCN(C3H5)2(where (H5C3)2NCSS-SSCN(C3H5)2is diallylthiuram disulfide), shows "net like structures." Intercalation of oxidized dithiocarbamates in the "galleries" of layered PbI2/CdI2is observed. HRTEM and AFM analysis of intercalates showed the particles to be nano-rods.
Solid-state spin crossover of Ni(II) in a bioinspired N3S 2 ligand field
Ma, Huaibo,Petersen, Jeffrey L.,Young, Victor G.,Yee, Gordon T.,Jensen, Michael P.
, p. 5644 - 5647 (2011)
The complex TpPh,MeNiS2CNMe2 [Tp Ph,Me = hydrotris(3-phenyl-5-methyl-1-pyrazolyl)borate] features a bioinspired N3S2 ligand set supporting a five-coordinate, trigonally distorted square-pyramidal geometry in the solid state. Spin crossover of Ni(II) was demonstrated by temperature-dependent X-ray crystallography and magnetic susceptibility measurements. The crystal lattice contains two independent molecules (i.e., Ni1 and Ni2). At 293 K, the observed bond lengths and susceptibility are consistent with high-spin (S = 1) Ni(II), and both molecules exhibit relatively short axial Ni-N bonds and long Ni-N and Ni-S equatorial bonds. At 123 K, the Ni1 complex remains high-spin, but the Ni2 molecule substantially crosses to a structurally distinct diamagnetic (S = 0) state with significant elongation of the axial Ni-N bond and offsetting contraction of the equatorial bonds. The temperature-dependent susceptibility data were fit to a spin equilibrium at Ni2 [ΔH° = 1.13(2) kcal/mol and ΔS° = +7.3(1) cal mol-1 K-1] consistent with weak coupling to lattice effects. Cooling below 100 K results in crossover of the Ni1 complex.
Hapten synthesis for the development of a competitive inhibition enzyme-immunoassay for thiram
Gueguen,Boisde,Queffelec,Haelters,Thouvenot,Corbel,Nodet
, p. 4492 - 4499 (2000)
An enzyme-linked immunosorbent assay (ELISA) was developed for the fungicide thiram. Two types of haptens were synthesized. The first type exhibits the two symmetrical N-alkyl dithiocarbamate patterns of thiram with a spacer arm linked to one of the N-methyl terminal group. The second type exhibits one of the two symmetrical N-alkyl dithiocarbamate patterns of thiram with a variable-length spacer arm linked to one sulfur atom. Polyclonal antibodies suitable for thiram detection were obtained from immunization with an hapten of the first type, while haptens of the second type were used as coating antigens to develop a competitive ELISA against thiram. The IC50 value for thiram was estimated to be 0.24 μg/mL, with a detection limit of 0.03 μg/mL. The assay seems to be thiram-specific since no or little cross-reaction with other dithiocarbamates were observed.
Substituted carbamothioic amine-1-carbothioic thioanhydrides as novel trichomonicidal fungicides: Design, synthesis, and biology
Mandalapu, Dhanaraju,Kushwaha, Bhavana,Gupta, Sonal,Krishna, Shagun,Srivastava, Nidhi,Shukla, Mahendra,Singh, Pratiksha,Chauhan, Bhavana S.,Goyani, Ravi,Maikhuri, Jagdamba P.,Sashidhara, Koneni V.,Kumar, Brijesh,Tripathi, Renu,Shukla, Praveen K.,Siddiqi, Mohammad I.,Lal, Jawahar,Gupta, Gopal,Sharma, Vishnu L.
, p. 632 - 645 (2017/12/08)
Sexually transmitted diseases like trichomoniasis along with opportunistic fungal infections like candidiasis are major global health burden in female reproductive health. In this context a novel non-nitroimidazole class of substituted carbamothioic amine-1-carbothioic thioanhydride series was designed, synthesized, evaluated for trichomonacidal and fungicidal activities, and was found to be more active than the standard drug Metronidazole (MTZ). Compounds were trichomonicidal in the MIC ranges of 4.77–294.1 μM and 32.46–735.20 μM against MTZ-susceptible and -resistant strains, respectively. Further, compounds inhibited the growth of at least two out of ten fungal strains tested at MIC of 7.50–240.38 μM. The most active compound (20) of this series was 3.8 and 9.5 fold more active than the MTZ against the two Trichomonas strains tested. Compound 20 also significantly inhibited the sulfhydryl groups present over Trichomonas vaginalis and was found to be more active than the MTZ in vivo. Further, a docking analysis carried out with cysteine proteases supported their thiol inhibiting ability and preliminary pharmacokinetic study has shown good distribution and systemic clearance.
Method for continuously preparing sodium dimethyl dithio carbamate by micro-reaction device
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Paragraph 0019-0021; 0022; 0023-0028, (2017/08/31)
The invention belongs to the field of fine chemical engineering product production, and particularly relates to a method for continuously preparing sodium dimethyl dithio carbamate by a micro-reaction device. The method for continuously preparing the sodium dimethyl dithio carbamate by the micro-reaction device is characterized in that a solution prepared by mixing dimethylamine and sodium hydroxide through a micro-mixer and carbon disulfide are sent into a micro-mixer in the micro-reactor through a metering pump, are fully mixed, and then are sent into a micro-reactor in the micro-reaction device for reaction, and a sodium dimethyl dithio carbamate solution is obtained, and is concentrated and dried to obtain the sodium dimethyl dithio carbamate. According to the method, precise matching of materials is realized, the materials are not volatilized, the dimethylamine and the carbon disulfide for reaction are volatile matters, but the micro-reaction device is completely sealed, so compared with a conventional tank reactor, the method has the advantage of avoiding material volatilization in the reaction process; rapid cooling is easy to realize; continuous production and conversion rate improvement are realized; the reaction is safe with controllable risk.
Energy-saving environment-friendly sodium dimethyldithiocarbamate production device and production method
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Paragraph 0064-0072, (2017/08/27)
The invention provides an energy-saving environment-friendly sodium dimethyldithiocarbamate production device and production method, and belongs to the field of preparation of chemical products. The production device comprises a reaction kettle and a first pipeline reactor for performing pre-reaction of dimethylamine and CS2, wherein an outlet of the first pipeline reactor communicates with the reaction kettle, and the reaction kettle is provided with a first feed port for introducing a NaOH solution. The production method comprises the following steps: introducing the dimethylamine and CS2 into the first pipeline reactor; performing pre-reaction to form a first material; then introducing the first material in the first pipeline reactor into the reaction kettle, simultaneously introducing the NaOH solution in the reaction kettle, and mixing for reaction. According to the production device and production method provided by the invention, by changing the addition sequence of the three raw materials, the one-step reaction for sodium dimethyldithiocarbamate generation can be very conveniently divided into two steps, so that the side reaction between the CS2 and the NaOH solution is effectively avoided, thereby improving the sodium dimethyldithiocarbamate purity and product quality.
Role of disulfide linkage in action of bis(dialkylaminethiocarbonyl)disulfides as potent double-Edged microbicidal spermicide: Design, synthesis and biology
Lal, Nand,Jangir, Santosh,Bala, Veenu,Mandalapu, Dhanaraju,Sarswat, Amit,Kumar, Lalit,Jain, Ashish,Kumar, Lokesh,Kushwaha, Bhavana,Pandey, Atindra K.,Krishna, Shagun,Rawat, Tara,Shukla, Praveen K.,Maikhuri, Jagdamba P.,Siddiqi, Mohammad I.,Gupta, Gopal,Sharma, Vishnu L.
, p. 275 - 290 (2016/04/26)
Trichomoniasis and candidiasis are amongst the most common morbidity-causing reproductive tract infections, generally treated by Metronidazole and Fluconazole respectively. Poor vaginal efficacy, drug-resistance and non-spermicidal nature limit their use as topical microbicidal contraceptives. Bis(dialkylaminethiocarbonyl)disulfides (4-38) were designed as dually active, non-surfactant molecules capable of eliminating Trichomonas vaginalis and Candida strains as well as irreversibly immobilizing 100% human sperm instantly, at doses non-cytotoxic to human cervical epithelial cells and vaginal microflora in vitro. Compounds 12, 16, 17 were fifty times more active than nonoxynol-9, OTC vaginal spermicide, and compounds 12 and 17 have shown remarkable in vivo activity in rabbit model. Most promising compound 17 has shown promise for further development as a double-edged vaginal microbicide due to their improved activity and safety along with notable in vivo trichomonicidal activity. Role of disulfide group was established by loss of spermicidal activity on chemical modifications (39-56). These disulfides might be targeting thiol groups present over cell membrane of human sperm and Trichomonas as shown by fluorescence labeling of free thiols.
