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128-09-6

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128-09-6 Usage

Chemical Description

N-chlorosuccinimide is a chlorinating agent used in organic synthesis.

Chemical Properties

white crystalline powder

Uses

Different sources of media describe the Uses of 128-09-6 differently. You can refer to the following data:
1. N-Chlorosuccinimide is a chlorinating agent for the side-chain halogenation of alkylarenes. It is used frequently for the side-chain chlorination of sensitive hetarenes.
2. N-Chlorosuccinimide (NCS) is a chlorinating and oxidizing reagent. It is more efficient when compared to other chlorinating agents, such as 1,3-dichloro-5,5-dimethylhydantoin (NDDH) and trichloroisocyanuric acid (TCCA) due to its high regioselectivity.N-Chlorosuccinimide is used as a chlorinating agent, mild oxidant and swimming pool disinfectant. It is used in the microdetermination of hydrazine salts by titrimetry as well as in the detection of arsenic in the +3 oxidative state. It is also employed in the production of rubber additives. Further, it is used as pharmaceutical intermediate and antibiotic drugs intermediate.

Definition

ChEBI: N-chlorosuccinimide is a five-membered cyclic dicarboximide compound having a chloro substituent on the nitrogen atom. It is a pyrrolidinone and a dicarboximide. It derives from a succinimide.

Flammability and Explosibility

Nonflammable

Check Digit Verification of cas no

The CAS Registry Mumber 128-09-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,2 and 8 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 128-09:
(5*1)+(4*2)+(3*8)+(2*0)+(1*9)=46
46 % 10 = 6
So 128-09-6 is a valid CAS Registry Number.
InChI:InChI=1/C4H4ClNO2/c5-6-3(7)1-2-4(6)8/h1-2H2

128-09-6 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
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  • Detail
  • TCI America

  • (C0291)  N-Chlorosuccinimide  >98.0%(T)

  • 128-09-6

  • 25g

  • 110.00CNY

  • Detail
  • TCI America

  • (C0291)  N-Chlorosuccinimide  >98.0%(T)

  • 128-09-6

  • 100g

  • 250.00CNY

  • Detail
  • TCI America

  • (C0291)  N-Chlorosuccinimide  >98.0%(T)

  • 128-09-6

  • 500g

  • 850.00CNY

  • Detail
  • Alfa Aesar

  • (A10310)  N-Chlorosuccinimide, 98%   

  • 128-09-6

  • 50g

  • 153.0CNY

  • Detail
  • Alfa Aesar

  • (A10310)  N-Chlorosuccinimide, 98%   

  • 128-09-6

  • 250g

  • 391.0CNY

  • Detail
  • Alfa Aesar

  • (A10310)  N-Chlorosuccinimide, 98%   

  • 128-09-6

  • 1000g

  • 1443.0CNY

  • Detail
  • Aldrich

  • (109681)  N-Chlorosuccinimide  98%

  • 128-09-6

  • 109681-100G

  • 219.96CNY

  • Detail
  • Aldrich

  • (109681)  N-Chlorosuccinimide  98%

  • 128-09-6

  • 109681-500G

  • 1,023.75CNY

  • Detail

128-09-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name N-chlorosuccinimide

1.2 Other means of identification

Product number -
Other names N-chlorobutanimide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:128-09-6 SDS

128-09-6Related news

N-Chlorosuccinimide (cas 128-09-6) as a versatile reagent for the sulfenylation of ketones: a facile synthesis of α-ketothioethers09/28/2019

The sulfenylation of ketones having α-hydrogens has been achieved using N-chlorosuccinimide (NCS) under mild reaction conditions to produce α-ketothioethers in excellent yields with high selectivity. The use of NCS makes this method quite simple, convenient and practical.detailed

Synthesis, growth and characterization of donor–acceptor π-conjugated N-Chlorosuccinimide (cas 128-09-6) single crystals for nonlinear optical applications10/01/2019

Single crystals of N-chlorosuccinimide (NCS) were grown by slow evaporation solution growth technique. The grown crystals were confirmed by single crystal X-ray diffraction and FT-IR studies. The theoretical factorial group analysis was carried and the vibrational modes are assigned. The dielect...detailed

N-Chlorosuccinimide (cas 128-09-6) as a novel agent for biofouling control in the polyamide reverse osmosis membrane process09/25/2019

One of the biggest challenges in reverse osmosis membrane process is formation of biofilms on membrane surface (biofouling) which significantly lowers membrane performance and shortens life cycle of the membrane. In an effort to find a more effective biocide to control biofouling, we investigate...detailed

N-Chlorosuccinimide (cas 128-09-6) promoted direct C(sp2)–H bond thiolation of the methoxybenzenes with thiophenols09/24/2019

A simple and an efficient procedure for the formation of diaryl sulfides via direct sp2 C–H functionalization have been developed from simple and readily available thiophenols and substituted methoxy benzenes. In this process thiophenols were used as the sulfur source. In this transformation br...detailed

Visible-light photocatalytic activation of N-Chlorosuccinimide (cas 128-09-6) by organic dyes for the chlorination of arenes and heteroarenes09/09/2019

A variety of arenes and heteroarenes are chlorinated in moderate to excellent yields using N-chlorosuccinimide (NCS) under visible-light activated conditions. A screening of known organic dye photocatalysts resulted in the identification of methylene green as the most efficient catalyst to use w...detailed

128-09-6Relevant articles and documents

Electrophilic Substitution of Hydrogen in Betulin and Diacetylbetulin

Bodrikov,Kurskii, Yu. A.,Chiyanov,Subbotin, A. Yu.

, p. 131 - 138 (2018)

Betulin and diacetylbetulin, which can be regarded as sterically hindered alkenes, reacted with N-chloro-, N-bromo-, and N-iodosuccinimides to give products of allylic and vinylic substitution in quantitative overall yield. The contribution of allylic substitution increases in the series Cl Br I. Quantum chemical simulation of the reactions of diacetylbetulin with N-halosuccinimides showed that, regardless of the electrophile power, all reactions involve open-chain carbocationic intermediates. The direction of deprotonation of the latter with formation of allylic or vinylic substitution products is determined by preferential orientation of the vacant orbital and C–Hlg bond.

CYCLOBUTYL AMIDE MONOACYLGLYCEROL LIPASE MODULATORS

-

, (2022/03/31)

Compounds of Formula (I), and pharmaceutically acceptable salts, isotopes, N-oxides, solvates, and stereoisomers thereof, pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions associated with MGL modulation, such as those associated with pain, psychiatric disorders, neurological disorders (including, but not limited to depression, major depressive disorder, treatment resistant depression, anxious depression, autism spectrum disorders, Asperger syndrome, and bipolar disorder), cancers and eye conditions: wherein R1, , R3, and L are as defined herein.

Convenient and environment-friendly synthesis of sulfonyl chlorides from S -alkylisothiourea salts via N-chlorosuccinimide chlorosulfonation

Yang, Zhanhui,Xu, Jiaxi

, p. 1675 - 1682 (2013/07/27)

A convenient, practical, and environmentally friendly method for the synthesis of sulfonyl chlorides has been developed. Structurally diverse sulfonyl chlorides were synthesized in moderate to excellent yields from S-alkylisothiourea salts, which can be easily prepared from readily accessible alkyl halides or mesylates and inexpensive thiourea, via N-chlorosuccinimide chlorosulfonation. In large-scale syntheses, the byproduct succinimide from 'waste water' can be conveniently converted into the starting reagent N-chlorosuccinimide with sodium hypochlorite (bleach) to make the method sustainable. Georg Thieme Verlag Stuttgart, New York.

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