1668-10-6Relevant articles and documents
Cobalt, nickel and copper complexes with glycinamide: Structural insights and magnetic properties
Vu?ak, Darko,Smre?ki, Neven,Prugove?ki, Biserka,Dilovi?, Ivica,Kirasi?, Inka,?ili?, Dijana,Muratovi?, Senada,Matkovi?-?alogovi?, Dubravka
, p. 21637 - 21645 (2019)
Ten new compounds of Co, Ni and Cu with glycinamide (HL = glycinamide): [Co(H2O)2(HL)2]Cl2 (1a), [Co(H2O)2(HL)2]Br1.06Cl0.94 (1b), [Co(H2O)2(HL)2]I2 (1c), [Ni(H2O)2(HL)2]Cl2 (2a), [Ni(H2O)2(HL)2]Br0.94Cl1.06 (2b), [Ni(H2O)2(HL)2]I2 (low and room temperature polymorph, 2cLT and 2cRT), [CuCl2(HL)2] (3a), [CuBr1.3Cl0.7(HL)2] (3b) and {[Cu(HL)2]2[Cu2I6]}n (3c), as well as glycinamide hydroiodide (H2LI) and a new polymorph of glycinamide hydrochloride (β-H2LCl) were prepared and characterized by single-crystal X-ray diffraction, infrared spectroscopy, thermal analysis (TG/DTA) and ESR spectroscopy. 1a, 1b, 2a and 2b are isostructural, as well as 1c and 2cRT, while the Cu compounds (3a-c) have entirely different molecular structures. All investigated compounds are mononuclear with exception of the 1D coordination polymer 3c. Compound 3c contains copper ions in the mixed oxidation state Cu(i) and Cu(ii) with interesting magnetic properties. Paramagnetic behaviour was found in 1a, 1b, 3a and 3b. Temperature induced polymorphic transformation was observed in 2c. Compounds 1a and 3a showed moderate antiproliferative activity and selectivity toward the human breast tumor cell line MCF-7.
REDUCING UNDESIRED POLYMERIZATION IN HYDROCARBON CRACKING PROCESSES
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, (2009/01/20)
The present invention relates to a method to inhibit the polymerization of a carbonyl compound in a basic wash unit operation in a hydrocarbon cracking process, comprising: contacting a stream comprising at least one carbonyl compound with a compound selected from the group consisting of mercaptoacetic acid and alkyl esters thereof and salts thereof and mixtures thereof, wherein said compound is selected such that it remains water-soluble and base-soluble and does not flocculate in said stream; wherein said steam is contacted with said compound either before or at the same time as said stream enters said basic wash unit operation.
Fluorobenzamides and uses thereof
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, (2008/06/13)
The invention relates to fluorobenzamide derivatives of the formula wherein R1, R2, R3 R4, R5, R6 and R7 are as defined herein. =, The compounds of the invention are selective monoamine oxidase B inhibitors and therefore they are suitable for the treatment of diseases mediated by monoamine oxidase B, such as Alzheimer's disease or senile dementia.
Preparation and purification of antiviral disulfonic acid disodium salt
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, (2008/06/13)
The present invention provides a new process and intermediates for the production of antiviral compound 4′,4-bis-{4,6-bis-[3-(bis-carbamoyl-methyl-1-sulfamoyl)-phenylamino]-[1,3,5]triazin-2-ylamino}-biphenyl-2,2′-disulfonic acid and its pharmaceutically acceptable salts.
Synthesis of α-amino dithioesters and endothiodipeptides
Hartke, Klaus,Barrmeyer, Stephan
, p. 251 - 256 (2007/10/03)
The α-amino ester hydrochlorides (1) are converted into N-protected α-amino amides (3), α-amino thioamides (4) and α-amino dithiomethylesters (5). Condensation of 5 with the alkali salts of α-amino acids gives rise to the endothiodipeptide alkali salts (7). Johann Ambrosius Barth 1996.
Comparative Studies on the Reactivity of 4-Methylene-1-oxa-6,9-diazaspirodecane-7,10-dione, 1-Acetyl-3-hydroxy-3-vinyl-2,5-piperazinedione, and Bicyclomycin. Examination of a Key Structural Element Necessary for Bicyclomycin-Mediated Transformations
Oh, Yeong Soo,Kohn, Harold
, p. 3662 - 3672 (2007/10/02)
Two select mimics, 4-methylene-1-oxa-6,9-diazaspirodecane-7,10-dione (8) and 1-acetyl-3-hydroxy-3-vinyl-2,5-piperazinedione (7) of the structurally novel antibiotic, bicyclomycin (1), have been prepared.Comparison of the chemical reactivity of 7 versus 1 both in the presence and absence of added nucleophiles at various "pH" values has been provided important new information concerning the role of key structural elements present in bicyclomycin.The product profiles determined for 7 indicated that modification of the terminal double bond proceeded through an α,β-unsaturated ring imine intermediate (i.e., 43).Correspondingly, activation of the exo-methylene group in bicyclomycin is believed to occur through initial hemiaminal bond scission to give a ring-opened α,β-unsaturated carbonyl species (i.e., 2).Functionalization of the terminal double bond in 7 has been shown to proceed under milder conditions than that required for 1.These results demonstrated that incorporation of the exo-methylene group within the O(2)-C(3)-C(4)-C(5) bridge in 1 required that the terminal double bond activation pathway procced by an alternative, energetically more-demanding pathway than that observed for 7.Ramifications of the decreased reactivity noted for 1 are to allow other functional groups (i.e., the C(1)-triol moiety) in the antibiotic to have important catalytic roles in the drug modification processes and to permit thiolate species (the proposed biological targets?) to effectively compete with other nucleophiles for 2.
CONVERSION OF α-AMINONITRILES TO AMIDES BY A NEW PINNER TYPE REACTION
Lee, Young Bok,Goo, Yang Mo,Lee, Youn Young,Lee, Jae Keun
, p. 1169 - 1170 (2007/10/02)
α-Aminonitriles were converted exclusively to the amides by 2-mercaptoethanol in anhydrous THF at -78 deg C by bubbling dry HCl gas.
4-Homoisotwistane-aminoacid amides
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, (2008/06/13)
Compounds having the formula STR1 wherein a is 0 or 1, R1 is hydrogen or lower alkyl, A is lower alkylene or lower alkylidene, and R2 and R3, which can be the same or different, are hydrogen, lower alkyl, cycloalkyl, benzyl or substituted benzyl, or STR2 is a saturated heterocyclic ring, and acid addition salts thereof, possess anti-viral activity and reduced activity on the central nervous system.
