Relevant articles and documents
All total 46 Articles be found
All total 46 Articles be foundNovel thermo- and pH-responsive hydroxypropyl cellulose- and poly (l-glutamic acid)-based microgels for oral insulin controlled release
Bai, Yunyan,Zhang, Zhe,Zhang, Aiping,Chen, Li,He, Chaoliang,Zhuang, Xiuli,Chen, Xuesi
, p. 1207 - 1214 (2012)
Novel smart microgel particles made of poly (l-glutamic acid-2-hydroxylethyl methacrylate) (PGH) and hydroxypropyl cellulose-acrylic acid (HPC-AA) have been successfully prepared via emulsion polymerization. The dynamic light scattering measurement reveals that the average hydrodynamic radius 〈Rh〉 and hydrodynamic radius distributions f (R h) of the microgel particles depend on the temperature and pH value thus the microgel particles exhibit both pH- and temperature-sensitivity. In vitro release study shows that the amount of insulin released from microgels in the gastric juice (at pH 1.2) is significantly less than that in the intestinal fluid (at pH 6.8). These results indicate that the resultant microgels are of potential for use in intelligent oral drug delivery systems.
BOROXAZOLIDONES AS SIMULTANEOUS PROTECTION OF THE AMINO AND CARBOXYL GROUP IN α-AMINO ACIDS
Nefkens, G. H. L.,Zwanenburg, B.
, p. 2995 - 2998 (1983)
The synthesis of boroxazolidones 1 from a variety of α-amino acids is given.These compounds 1 show a strong intramolecular coordination between B and the amino group.These heterocycles can serve as protected α-amino acids in which the α-amino and the carboxyl function are simultaneously blocked, while the side chain remains free for further reactions.The boroxazolidines were reconverted into α-amino acids under mild acid conditions.Using this methodology aspartic acid was converted into β-benzyl aspartate and glutamic acid into γ-benzyl glutamate.
Synthesis and self-assembly of thermoresponsive amphiphilic biodegradable polypeptide/poly(ethyl ethylene phosphate) block copolymers
Wu, Qiuhua,Zhou, Dan,Kang, Renyu,Tang, Xiuping,Yang, Qi,Song, Ximing,Zhang, Guolin
, p. 2850 - 2858 (2014)
We report the design and synthesis of new fully biodegradable thermoresponsive amphiphilic poly(γ-benzyl L-glutamate)/poly(ethyl ethylene phosphate) (PBLG-b-PEEP) block copolymers by ring-opening polymerization of N-carboxy-γ-benzyl L-glutamate anhydride (BLG-NCA) with amine-terminated poly(ethyl ethylene phosphate) (H2N-PEEP) as a macroinitiator. The fluorescence technique demonstrated that the block copolymers could form micelles composed of a hydrophobic core and a hydrophilic shell in aqueous solution. The morphology of the micelles as determined by transmission electron microscopy (TEM) was spherical. The size and critical micelle concentration (CMC) values of the micelles showed a decreasing trend as the PBLG segment increased. However, UV/Vis measurements showed that these block copolymers exhibited a reproducible temperature-responsive behavior with a lower critical solution temperature (LCST) that could be tuned by the block composition and the concentration.
On proteins and their decomposition products. XVII. Synthesis of the tri-and tetrapeptide derivatives of proline and hydroxyproline.
HEYNS,LEGLER
, p. 161 - 183 (1960)
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Microwave assisted synthesis and antimicrobial study of Schiff base vanadium(IV) complexes of phenyl esters of amino acids
Wazalwar, Sachin S.,Bhave, Narayan S.,Dikundwar, Amol G.,Ali, Parvez
, p. 459 - 464 (2011)
Schiff base vanadium(IV) complexes of phenyl esters of the two acidic amino acids, i.e., aspartic and glutamic acid, were synthesized. The phenyl esters of these amino acids were synthesized by conventional method whereas the Schiff base vanadium(IV) complexes were synthesized using microwave irradiation. The complexes were characterized by spectroscopic tools such as IR, 1H NMR, mass (ES), ESR, and UV visible spectroscopy. All the complexes were studied for antibacterial and antifungal activity and found to be moderately active. Copyright Taylor & Francis Group, LLC.
Preparation method of N-fluorenylmethoxycarbonyl-gamma-(S-triphenylmethyl-cysteamine)-L-glutamic acid
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Paragraph 0061, (2020/10/05)
The invention provides a preparation method of N-fluorenylmethoxycarbonyl-gamma-(S-triphenylmethyl-cysteamine)-L-glutamic acid. The preparation method mainly solves the technical problems of complexity, long period, high cost, and low yield of an original process, and comprises the following steps: (1) preparing N-fluorenylmethoxycarbonyl-L-glutamic acid; (2) preparing N-fluorenylmethoxycarbonyl-L-glutamic acid-1-benzyl ester; (3) preparing S-triphenylmethyl cysteamine; (4) preparing N-fluorenylmethoxycarbonyl-gamma-(S-triphenylmethyl-cysteamine)-L-glutamic acid-alpha-benzyl ester; and (5) preparing N-fluorenylmethoxycarbonyl-gamma-(S-triphenylmethyl-cysteamine)-L-glutamic acid. The method is rapid, high in yield and simple in separation and purification, and the used solvent is environment-friendly and is suitable for mass production.
SPIRO-LACTAM NMDA RECEPTOR MODULATORS AND USES THEREOF
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Page/Page column 36, (2019/08/26)
Disclosed are compounds having potency in the modulation of NMDA receptor activity. Such compounds can be used in the treatment of conditions such as depression and related disorders as well as other disorders.
