19227-13-5

Basic information

• Product Name: 4-Methylbenzamide oxime
• Synonyms: N-HYDROXY-4-METHYL-BENZAMIDINE;N'-HYDROXY-4-METHYLBENZENECARBOXIMIDAMIDE;P-TOLUAMIDEOXIME;n-hydroxy-4-methyl-benzenecarboximidamid;p-tolamidoxime;p-toluamidoxime;BUTTPARK 33\11-54;ART-CHEM-BB B022751
• CAS NO: 19227-13-5
• Molecular Formula: C₈H₁₀N₂O
• Molecular Weight: 150.18
• Product Categories: OXIME;pharmacetical
• Mol File: 19227-13-5.mol
• Article Data: 134

Chemical Properties

• Melting Point: 140-145 °C(lit.)
• Boiling Point: 258.052 °C at 760 mmHg
• Flash Point: 109.866 °C
• Appearance: /
• Density: 1.15 g/cm³
• Vapor Pressure: 0.000355mmHg at 25°C
• Refractive Index: 1.539
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 6.95±0.69(Predicted)
• CAS DataBase Reference: 4-Methylbenzamide oxime(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methylbenzamide oxime(19227-13-5)
• EPA Substance Registry System: 4-Methylbenzamide oxime(19227-13-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: XS4870000
• HazardClass: IRRITANT
• Hazardous Substances Data: 19227-13-5(Hazardous Substances Data)

Usage

Description

4-Methylbenzamide oxime is intended to be used as a building block in drug discovery chemistry.

Uses

N-Hydroxy-4-methyl-benzenecarboximidamide is a reactant used in the preparation of naphthyridine-based polycyclic hetarenes from N-hydroxybenzamidines and alkynes.

General Description

4-Methylbenzamide oxime is a benzonitrile derivative that can be prepared from 4-methylbenzonitrile and hydroxylamine hydrochloride. Its crystalline structure shows the presence of both intramolecular and intermolecular hydrogen bonds. 3-Aryl-5-trinitromethyl-1,2,4-oxadiazoles undergoes hydrolysis under acidic conditions to form 4-methylbenzamide oxime as one of the product.

InChI:InChI=1/C11H15NO2/c1-12-11(7-10(8-13)14-12)9-5-3-2-4-6-9/h2-6,10-11,13H,7-8H2,1H3

Upstream product

• 104-85-8 para-methylbenzonitrile 
• 75-05-8 acetonitrile 
• 121-44-8 triethylamine 
• 125324-43-8 (3aR,9aR)-3,8-Di-p-tolyl-3a,9a-dihydro-5aH-isoxazolo[4,5-e][1,2,4]oxadiazolo[4,5-a]pyridine 
• 125338-27-4 3-p-Tolyl-5-[(E)-2-(3-p-tolyl-isoxazol-4-yl)-vinyl]-4,5-dihydro-[1,2,4]oxadiazole 
• 68451-80-9 C₁₆H₁₆N₂O₃ 
• 68451-93-4 O-(p-Nitrobenzoyl)-para-tolylamidoxime 
• 68451-87-6 C₁₅H₁₃ClN₂O₂ 
• 41110-16-1 C₁₅H₁₄N₂O₂ 
• 5470-11-1 hydroxylamine hydrochloride 
• 104-87-0 4-methyl-benzaldehyde 
• 3235-02-7 p-methylbenzaldehyde oxime 
• 67-56-1 methanol 

Downstream Products

• 20069-37-8 3-(4-tolyl)-1,2,4-thiadiazole-5-(2H)-thione 
• 31827-21-1 N-ethoxycarbonyloxy-4-methyl-benzamidine 
• 31827-28-8 4,5-dihydro-3-(p-tolyl)-1,2,4-oxadiazol-5-one 
• 110449-27-9 5-acetonyl-3-(p-tolyl)-1,2,4-oxadiazole 
• 126868-27-7 5-methyl-3-(p-tolyl)-1,2,4-oxadiazole 
• 61773-15-7 N-(2,4-dinitro-phenoxy)-4-methyl-benzamidine 
• 58589-02-9 2-(3-(p-tolyl)-1,2,4-oxadiazol-5-yl)aniline 
• 91393-16-7 ethyl 3-(4-methylphenyl)-1,2,4-oxadiazole-5-carboxylate 
• 16013-06-2 3-(4-methylphenyl)-1,2,4-oxadiazole 
• 622-51-5 p-tolylurea 
• 110991-32-7 4,5-dihydro-3-(p-tolyl)-1,2,4-thiadiazol-5-one 
• 110991-33-8 di(p-toluamide) O,O-carboxime 
• 610304-53-5 1,1-dimethylethyl 2-(S)-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-4-[[[1-amino-(4-methylphenyl)methyl]imino]oxy]-4-oxobutanoate 
• 81386-30-3 5-methyl-3-(4-methylphenyl)-1,2,4-oxadiazole 

Relevant articles and documents

Synthesis and analgesic profile of novel N-containing heterocycle derivatives: Arylidene 3-phenyl-1,2,4-oxadiazole-5-carbohydrazide

This paper describes recent results of a research program aimed at the synthesis and pharmacological evaluation of new heterocyclic N-acylhydrazone (NAH) compounds, belonging to the arylidene (3-phenyl)-1,2,4-oxadiazolyl-5- carboxyhydrazide (8a-p) series.

Discovery of 1,2,4-oxadiazole derivatives as a novel class of noncompetitive inhibitors of 3-hydroxykynurenine transaminase (HKT) from Aedes aegypti

The mosquito Aedes aegypti is the vector of arboviruses such as Zika, Chikungunya, dengue and yellow fever. These infectious diseases have a major impact on public health. The unavailability of effective vaccines or drugs to prevent or treat most of these

Synthesis and Biological Screening of Novel 5-(5-Aryl-1-phenyl-1H-pyrazol-3-yl)-3-aryl-1,2,4-oxadiazole Derivatives

A new series of 5-(5-aryl-1-phenyl-1H-pyrazol-3-yl)-3-aryl-1,2,4-oxadiazole (6a-o) have been synthesized by a cyclocondensation reaction of ethyl 5-(4-chlorophenyl)-1-phenyl-1H-pyrazole-3-carboxylate (3a-c) with aryl imidoxime (5a-e). The newly synthesize

Design, synthesis, and biological evaluation of 1,2,4-oxadiazole-containing pyrazolo[3,4-b]pyridinones as a new series of AMPKɑ1β1γ1 activators

Adenosine monophosphate-activated protein kinase (AMPK) plays a key role in maintaining whole-body homeostasis and has been regarded as a therapeutic target for the treatment of diabetic nephropathy (DN). Herein, a series of 1,2,4-oxadiazole-containing py

Catalyst-free, one-pot strategy to access 3-substituted-5-amino-1,2,4-thiadiazoles in water

A protocol has been devised for the synthesis of 3-substituted 5-amino-1,2,4-thiadiazoles utilizing isothiocyanates, amidoximes and water as an eco-friendly solvent. The strategy involves consecutive C?N and S?N bonds formation in a one-pot reaction under