3033-62-3

Basic information

• Product Name: Bis(2-dimethylaminoethyl) ether
• Synonyms: 2,2’-oxybis[n,n-dimethyl-ethanamin;2,2’-oxybis[N,N-dimethyl-Ethanamine;A 99;A 99 (Amine);a99(amine);dabcobl11;dabcobl19;dabcobl19i
• CAS NO: 3033-62-3
• Molecular Formula: C₈H₂₀N₂O
• Molecular Weight: 160.26
• EINECS: 221-220-5
• Mol File: 3033-62-3.mol

Chemical Properties

• Boiling Point: 189 °C 760 mm Hg
• Flash Point: 151 °F
• Appearance: A clear or yellow liquid
• Density: 0.841 g/mL at 25 °C
• Vapor Pressure: 49Pa at 20℃
• Refractive Index: n 20/D 1.430
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: Soluble in water
• PKA: 9.12±0.28(Predicted)
• Water Solubility: 100g/L at 20℃
• BRN: 1739668
• CAS DataBase Reference: Bis(2-dimethylaminoethyl) ether(CAS DataBase Reference)
• NIST Chemistry Reference: Bis(2-dimethylaminoethyl) ether(3033-62-3)
• EPA Substance Registry System: Bis(2-dimethylaminoethyl) ether(3033-62-3)

Safety Data

• Hazard Codes: T
• Statements: 20-22-24-34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 2927 6.1/PG 2
• WGK Germany: 2
• RTECS: KR9460000
• TSCA: Yes
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 3033-62-3(Hazardous Substances Data)

Usage

Uses

Used in Polyurethane Foam Production:
Bis(2-dimethylaminoethyl) ether is used as an efficient tertiary amine catalyst for the production of flexible polyurethane foams, particularly for high resilience and RIM products. Its use results in better physical and chemical properties of the products, such as resilience and elongation, compared to other products.
Used in Flexible Foam Products:
Bis(2-dimethylaminoethyl) ether is suitable for the production of almost all foam products, mainly for flexible foam products. Its high catalytic activity and smooth foaming properties make it an ideal choice for creating high-quality foam products.
Used in Manufacturing of Flexible Polyurethane Foams:
Bis(2-dimethylaminoethyl) Ether (Potassium Clavulanate EP Impurity M) is specifically used in the manufacturing of flexible polyurethane foams, contributing to the production of resilient and high-quality foam materials.
Safety Note:
Bis(2-dimethylaminoethyl) ether is toxic by inhalation, skin absorption, ingestion, and eye contact, so proper safety measures should be taken during its handling and use.

Preparation

The main methods for the synthesis of Bis(2-dimethylaminoethyl) ether are:(1) reaction of sodium dimethylaminoethanol and SO3 or chlorosulfonic acid;(2) Reaction of trimethylamine with dichloroethyl ether or dimethylaminoethoxyethyl ether;(3) One-step synthesis of dimethylamine and monoethyleneglycol under solid catalyst.

Reactivity Profile

Bis (2-(dimethylamino)ethyl)ether reacts as a base. Reacts exothermically with acids. May form explosive peroxides upon exposure to the air.

Safety Profile

Poison by skin contact.Moderately toxic by ingestion. Experimental reproductiveeffects. A severe skin and eye irritant.

Synthetic route

2-(N,N-dimethylamino)ethanol (108-01-0) + dimethyl amine (124-40-3) + acetylene (74-86-2) → Bis<2-(N,N-dimethylamino)aethyl>aether (3033-62-3)

Conditions	Yield
With potassium hydroxide In dibutyl ether at 100℃; for 5h;	90.4%

2-(N,N-dimethylamino)ethanol (108-01-0) → Bis<2-(N,N-dimethylamino)aethyl>aether (3033-62-3)

Conditions	Yield
In water at 175 - 180℃; for 3h; Temperature; Time;	78.5%
With 4-methyl-morpholine; ammonium tungstate at 145 - 155℃; for 15h; Reagent/catalyst; Autoclave; Inert atmosphere; Sealed tube;	73.6%
With sulfuric acid at 190℃; for 12h; Temperature; Reagent/catalyst;	65%

2-(N,N-dimethylamino)ethanol (108-01-0) + N-Methyldiethanolamine (105-59-9) → 2-((2-(2-(dimethylamino)ethoxy)ethyl)methyl-amino)-ethanol + Bis<2-(N,N-dimethylamino)aethyl>aether (3033-62-3)

Conditions	Yield
With 4-methyl-morpholine; silica-alumina at 145 - 155℃; for 15h; Catalytic behavior; Reagent/catalyst; Time; Concentration; Temperature; Autoclave; Inert atmosphere; Sealed tube; Overall yield = 95.6 %;	A 76.4% B 75 g

1-O-Dimethylaminoethyl-ethylenglykol (1704-62-7) + dimethyl amine (124-40-3) → Bis<2-(N,N-dimethylamino)aethyl>aether (3033-62-3)

Conditions	Yield
With hydrogen at 220℃; under 15001.5 - 142514 Torr; for 8h; Temperature; Pressure;	74.63%
With hydrogen at 200℃; under 5931.67 Torr; Product distribution / selectivity;	47 %Chromat.

2-(N,N-dimethylamino)ethanol (108-01-0) + 2-(dimethylamino)ethyl chloride (107-99-3) → Bis<2-(N,N-dimethylamino)aethyl>aether (3033-62-3)

Conditions	Yield
With sodium hydroxide; adogen 464 In tetrahydrofuran for 6h; Heating;	35%

dimethyl amine (124-40-3) + 3-oxa-1,5-dichloropentane (111-44-4) + benzene (71-43-2) → 4-methyl-morpholine (109-02-4) + Bis<2-(N,N-dimethylamino)aethyl>aether (3033-62-3)

Conditions	Yield
at 140℃;

dimethyl amine (124-40-3) + 3-oxa-1,5-dichloropentane (111-44-4) → Bis<2-(N,N-dimethylamino)aethyl>aether (3033-62-3)

Conditions	Yield
With ethanol at 120℃;
With benzene at 140℃;

sodium N,N-dimethylethanolamine (37616-36-7) + 2-(dimethylamino)ethyl chloride (107-99-3) → Bis<2-(N,N-dimethylamino)aethyl>aether (3033-62-3)

Conditions	Yield
With toluene

2-(dimethylamino)ethyl chloride (107-99-3) + benzene (71-43-2) + sodium-compound of acetamide → 2-(N,N-dimethylamino)ethanol (108-01-0) + Bis<2-(N,N-dimethylamino)aethyl>aether (3033-62-3) + 2-(dimethylamino)ethyl acetate (1421-89-2) + N-<2-(dimethylamino)ethyl>acetamide (3197-11-3)

Conditions	Yield
Produkt5: 1,2-Bis-dimethylamino-aethan;

1-O-Dimethylaminoethyl-ethylenglykol (1704-62-7) + methylamine (74-89-5) → 4-methyl-morpholine (109-02-4) + N,N,N'-trimethylbis(aminoethyl)ether (93240-93-8) + Bis<2-(N,N-dimethylamino)aethyl>aether (3033-62-3)

Conditions	Yield
With hydrogen at 195℃; under 11879 Torr; for 23.3h; Product distribution / selectivity; Compressed gas(es);	A 3.1 %Chromat. B 44.3 %Chromat. C 1.6 %Chromat.
With hydrogen; potassium nitrate at 200℃; under 4395.7 Torr; Product distribution / selectivity;
With hydrogen at 200℃; under 4369.84 Torr; Product distribution / selectivity;

dimethyl amine (124-40-3) + diethylene glycol (111-46-6) → 1-O-Dimethylaminoethyl-ethylenglykol (1704-62-7) + Bis<2-(N,N-dimethylamino)aethyl>aether (3033-62-3)

Conditions	Yield
With hydrogen; γ-Al2O3 (45 weight %), CuO (55 weight %), hydrogenated at 190℃; under 15001.5 Torr; Product distribution / selectivity;
Stage #1: diethylene glycol With C39H57ClNP2Rh In 5,5-dimethyl-1,3-cyclohexadiene; ethanol at -78℃; for 0.5h; Autoclave; Inert atmosphere; Stage #2: dimethyl amine In 5,5-dimethyl-1,3-cyclohexadiene; ethanol at 150℃; under 112511 Torr; for 120h; Solvent; Reagent/catalyst; Pressure; Autoclave; Inert atmosphere;

1-O-Dimethylaminoethyl-ethylenglykol (1704-62-7) → morpholine (110-91-8) + 4-methyl-morpholine (109-02-4) + N,N,N'-trimethylbis(aminoethyl)ether (93240-93-8) + 2-(2-aminoethoxy)-N,N-dimethylethanamine (85322-63-0) + Bis<2-(N,N-dimethylamino)aethyl>aether (3033-62-3) + bis-(2-(N,N-dimethylamino)ethoxyethyl)methylamine (65286-55-7) + [2-(2-amino-ethoxy)-ethyl]-[2-(2-dimethylamino-ethoxy)-ethyl]-methyl-amine (1257084-24-4) + bis-(2-(N,N-dimethylamino)ethoxyethyl)amine (1257084-22-2) + [2-(2-dimethylamino-ethoxy)-ethyl]-[2-(2-methylamino-ethoxy)-ethyl]-amine (1257084-23-3)

Conditions	Yield
With ammonia; copper chromite at 200℃; under 52505.3 Torr; Product distribution / selectivity; Industry scale;

...Expand

dimethyl amine (124-40-3) + diethylene glycol (111-46-6) → Bis<2-(N,N-dimethylamino)aethyl>aether (3033-62-3)

Conditions	Yield
With hydrogen; shaped bodies of reduced CuO/γ-Al2O3 (55 wt%/45 wt%) at 210℃; under 15001.5 Torr; Product distribution / selectivity;

1-O-Dimethylaminoethyl-ethylenglykol (1704-62-7) + methylamine (74-89-5) → N,N,N'-trimethylbis(aminoethyl)ether (93240-93-8) + Bis<2-(N,N-dimethylamino)aethyl>aether (3033-62-3)

Conditions	Yield
With copper chromite at 166℃; under 7500.75 Torr; for 513h;	A 26.81 %Chromat. B 19.37 %Chromat.

1-O-Dimethylaminoethyl-ethylenglykol (1704-62-7) + trimethylamine (75-50-3) → Bis<2-(N,N-dimethylamino)aethyl>aether (3033-62-3)

Conditions	Yield
Stage #1: 1-O-Dimethylaminoethyl-ethylenglykol With thionyl chloride In toluene for 1.5h; Reflux; Stage #2: trimethylamine at 50 - 80℃; for 3h; Stage #3: With ethylenediamine at 100 - 170℃; for 3h; Temperature; Autoclave;	132 g

1-O-Dimethylaminoethyl-ethylenglykol (1704-62-7) + dimethyl amine (124-40-3) → 4-methyl-morpholine (109-02-4) + Bis<2-(N,N-dimethylamino)aethyl>aether (3033-62-3)

Conditions	Yield
With hydrogen at 230℃; under 11400.8 Torr; Temperature; Pressure; Reagent/catalyst;

2,2'-diiodoethyl ether (34270-90-1) + Bis<2-(N,N-dimethylamino)aethyl>aether (3033-62-3) → N,N,N',N'-tetramethyl-1,7-diaza-4,10-dioxacyclododecane di-iodide

Conditions	Yield
In acetonitrile under 7500600 Torr; for 48h; Mechanism; Quantum yield; Ambient temperature; further substrates and reactants;	99%
In acetonitrile under 7500600 Torr; for 48h; Ambient temperature;	99%
In acetonitrile at 25℃; under 8250660 Torr; for 20h;	99%

Bis<2-(N,N-dimethylamino)aethyl>aether (3033-62-3) + 1,2-bis-(2-iodoethoxy)benzene (110431-62-4) → N,N,N',N'-tetramethyl-5,6-benzo-1,10-diaza-4,7,13-trioxacyclopentadecane di-iodide

Conditions	Yield
In acetonitrile under 7500600 Torr; for 48h; Ambient temperature;	96%
In acetonitrile at 25℃; under 8250660 Torr; for 20h;	96%

Bis<2-(N,N-dimethylamino)aethyl>aether (3033-62-3) + 1,2-bis-(2-iodoethoxy)ethane (36839-55-1) → N,N,N',N'-tetramethyl-1,10-diaza-4,7,13-trioxacyclopentadecane di-iodide

Conditions	Yield
In acetonitrile under 7500600 Torr; for 48h; Ambient temperature;	95%
In acetonitrile at 25℃; under 8250660 Torr; for 20h;	95%

Bis<2-(N,N-dimethylamino)aethyl>aether (3033-62-3) + 1-dodecylbromide (143-15-7) → 2,2'-bis(dodecyldimethylammonium)diethyl ether dibromide

Conditions	Yield
In water; acetonitrile at 80℃; for 55h; Solvent;	95%

Bis<2-(N,N-dimethylamino)aethyl>aether (3033-62-3) + 1-(bromomethyl)-4-(dodecyloxy)benzene (123436-89-5) → bis{2-N,N-dimethyl-N-[p-(n-dodecyloxybenzyl)]ammonium} bromide ethyl ether

Conditions	Yield
In acetonitrile for 1h; Reflux;	94%

2-Bromoethyl ethyl ether (592-55-2) + Bis<2-(N,N-dimethylamino)aethyl>aether (3033-62-3) → 2,2'-oxybis(N-(2-ethoxyethyl)-N,N-dimethylethanammonium) bromide

Conditions	Yield
In acetone for 24h; Cooling with ice; Reflux;	88%

1-bromo dodecane (112-29-8) + Bis<2-(N,N-dimethylamino)aethyl>aether (3033-62-3) → bis(N-decyl-N,N-dimethylethylammonium)ether dibromide

Conditions	Yield
In acetonitrile at 80℃; for 55h;	83%

Bis<2-(N,N-dimethylamino)aethyl>aether (3033-62-3) + potassium hexamethylsilazane (40949-94-8) → C40H112K4N8O2Si8

Conditions	Yield
In hexane Inert atmosphere; Schlenk technique;	66%

Bis<2-(N,N-dimethylamino)aethyl>aether (3033-62-3) + potassium hexamethylsilazane (40949-94-8) → C22H58KN5O2Si2

Conditions	Yield
In hexane Inert atmosphere; Schlenk technique;	62%

Bis<2-(N,N-dimethylamino)aethyl>aether (3033-62-3) + 2-tert-butyl-4,5-di-(1,1-dimethylpropyl) imidazole (1279010-11-5) + bis(tetrahydrofuran)strontium di(bis(trimethylsilyl)amide) (133766-06-0) → bis(2-tert-butyl-4,5-di-tert-amylimidazolyl)(2,2'-oxybis(N,N-dimethylethylamine))strontium (1279016-87-3)

Conditions	Yield
In hexane at 20℃; Inert atmosphere;	43%

2,2,6,6-tetramethyl-piperidine (768-66-1) + n-butyllithium (109-72-8, 29786-93-4) + Bis<2-(N,N-dimethylamino)aethyl>aether (3033-62-3) + diisobutylaluminum chloride (1779-25-5) → [Li(μ-2,2,6,6-tetramethylpiperidide)(μ-bis[2-(N,N-dimethylamino)ethyl]ether)Al(isobutyl)2]

Conditions	Yield
Stage #1: 2,2,6,6-tetramethyl-piperidine; n-butyllithium In hexane at 20℃; for 0.166667h; Inert atmosphere; Schlenk technique; Stage #2: diisobutylaluminum chloride In hexane for 1h; Inert atmosphere; Schlenk technique; Stage #3: Bis<2-(N,N-dimethylamino)aethyl>aether In hexane Inert atmosphere; Schlenk technique;	42%

Bis<2-(N,N-dimethylamino)aethyl>aether (3033-62-3) + epichlorohydrin (106-89-8) → N,N′-(oxybis(ethane-2,1-diyl))bis(3-chloro-2-hydroxy-N,N-dimethylpropan-1-aminium) chloride

Conditions	Yield
With hydrogenchloride In water at 25 - 70℃; for 6h; pH=< 2 - 8.5;	39.4%

di(pyridin-2-yl)amine (1202-34-2) + Bis<2-(N,N-dimethylamino)aethyl>aether (3033-62-3) → [(N,N,N′,N′-tetramethyldiaminoethylether)Na(2,2′-dipyridylamide)]2

Conditions	Yield
Stage #1: di(pyridin-2-yl)amine With butylsodium In hexane for 1h; Inert atmosphere; Schlenk technique; Stage #2: Bis<2-(N,N-dimethylamino)aethyl>aether In hexane at -30℃; for 48h; Inert atmosphere; Schlenk technique;	37%

Bis<2-(N,N-dimethylamino)aethyl>aether (3033-62-3) + butylsodium (3525-44-8) + 1,1,1,3,3,3-hexamethyl-disilazane (999-97-3) + sodium iodide (7681-82-5) → C30H90IN5Na5Si10(1-)*C16H40N4NaO2(1+)

Conditions	Yield
Stage #1: butylsodium; 1,1,1,3,3,3-hexamethyl-disilazane In hexane for 2h; Inert atmosphere; Schlenk technique; Stage #2: sodium iodide In hexane for 24h; Inert atmosphere; Schlenk technique; Stage #3: Bis<2-(N,N-dimethylamino)aethyl>aether In hexane for 15h; Inert atmosphere; Schlenk technique;	36%

Bis<2-(N,N-dimethylamino)aethyl>aether (3033-62-3) + 1-lithio-2-tert-butyl-1,2-dihydropyridine → C17H34LiN3O

Conditions	Yield
In tetrahydrofuran; hexane at -30℃; for 168h; Inert atmosphere;	32%

ethyl bromide (74-96-4) + Bis<2-(N,N-dimethylamino)aethyl>aether (3033-62-3) → N,N'-diethyl-N,N,N',N'-tetramethyl-N,N'-(3-oxa-pentanediyl)-di-ammonium; dibromide (64049-67-8)

Conditions	Yield
With acetone

Bis<2-(N,N-dimethylamino)aethyl>aether (3033-62-3) + benzyl chloride (100-44-7) → N,N'-dibenzyl-N,N,N',N'-tetramethyl-N,N'-(3-oxa-pentanediyl)-di-ammonium; dichloride (63722-05-4)

Bis<2-(N,N-dimethylamino)aethyl>aether (3033-62-3) + ethyl iodide (75-03-6) → N,N'-diethyl-N,N,N',N'-tetramethyl-N,N'-(3-oxa-pentanediyl)-di-ammonium; diiodide

Bis<2-(N,N-dimethylamino)aethyl>aether (3033-62-3) + chloroacetic acid ethyl ester (105-39-5) → N,N'-bis-ethoxycarbonylmethyl-N,N,N',N'-tetramethyl-N,N'-(3-oxa-pentanediyl)-di-ammonium; dichloride

Conditions	Yield
With acetone
In isopropyl alcohol for 8h; Reflux;

Bis<2-(N,N-dimethylamino)aethyl>aether (3033-62-3) + methyl iodide (74-88-4) → hexa-N-methyl-N,N'-(3-oxa-pentanediyl)-di-ammonium; diiodide (2576-43-4)

Conditions	Yield
With ethanol

Bis<2-(N,N-dimethylamino)aethyl>aether (3033-62-3) → F-bis[2-(N,N-dimethylamino)ethyl] ether

Conditions	Yield
With hydrogen fluoride In water electrochemical fluorination; Yield given;

Upstream product

• 37616-36-7 sodium N,N-dimethylethanolamine 
• 107-99-3 2-(dimethylamino)ethyl chloride 
• 71-43-2 benzene 
• 1704-62-7 1-O-Dimethylaminoethyl-ethylenglykol 
• 75-50-3 trimethylamine 
• 124-40-3 dimethyl amine 
• 108-01-0 2-(N,N-dimethylamino)ethanol 
• 105-59-9 N-Methyldiethanolamine 
• 74-86-2 acetylene 
• 111-46-6 diethylene glycol 
• 74-89-5 methylamine 
• 111-44-4 3-oxa-1,5-dichloropentane 

Downstream Products

• 63722-05-4 N,N'-dibenzyl-N,N,N',N'-tetramethyl-N,N'-(3-oxa-pentanediyl)-di-ammonium; dichloride 
• 2576-43-4 hexa-N-methyl-N,N'-(3-oxa-pentanediyl)-di-ammonium; diiodide 
• 50-00-0 formaldehyd 
• 68-12-2 N,N-dimethyl-formamide 

Relevant articles and documents

Selective Synthesis of Bisdimethylamine Derivatives from Diols and an Aqueous Solution of Dimethylamine through Iridium-Catalyzed Borrowing Hydrogen Pathway

Bisdimethylamine derivatives are an important class of compounds in the polymer and pharmaceutical industries. However, existing methods for the synthesis of these compounds have several drawbacks such as low selectivity, use of toxic reagents, and generation of waste. In this study, a new system was developed for the selective synthesis of bisdimethylamine derivatives using a diol and dimethylamine as starting materials and an iridium complex bearing an N-heterocyclic carbene ligand as catalyst. The starting materials were easily available, less toxic, inexpensive, and easy to handle. The reaction proceeded efficiently through a borrowing hydrogen pathway under aqueous conditions, without any additional organic solvent, to afford various bisdimethylamine derivatives in good to excellent yields.

Cyclic preparation method of dimethylamino ethyl ether

The invention provides a cyclic preparation method of dimethylamino ethyl ether, which comprises the following steps: taking N,N-dimethyl ethanol amine as a raw material, reacting under the catalyticaction of loaded amorphous carbon and composite acid to generate dimethylamino ethyl ether and a byproduct namely water. Compared with the conventional method, the method has the advantages of low reaction temperature, high selectivity, and cyclic utilization of the catalyst and composite acid, the environment is protected, and a great economic value is created.

Production method of BDMAEE

The invention discloses a production method of BDMAEE. The production method comprises the following steps: adding sulfuric acid, DMEA and super-strong solid acid taken as a catalyst in a reaction vessel to perform an etherification reaction; adding an extractant to obtained etherification liquid, and introducing ammonia to an extraction system to neutralize while stirring, and stopping introducing ammonia to neutralize until pH is 11-13; filtering an obtained product to achieve solid-liquid separation; washing and drying a solid obtained by filtering to obtain ammonium sulfate; and carrying out distillation on filtrate obtained by filtering to obtain BDMAEE. BDMAEE prepared by the method disclosed by the invention is high in efficiency and product yield, high in purity and less in wastewater, and can realize resource utilization of by-products.

Method for homogeneously catalyzing alcohol amination

The invention relates to a method for homogeneously catalyzing alcohol amination. The method comprises the following steps: mixing diethylene glycol or 1,6-hexanediol, dimethylamine, a ruthenium metalcatalyst and a non-polar solvent and carrying out homogeneous catalysis reaction; separating. According to the method provided by the invention, under the catalysis of a noble metal (rhodium, ruthenium and iridium) metallic catalyst, the diethylene glycol which has a cheap price and is easy to obtain or the 1,6-hexanediol is directly subjected to the amination by utilizing the dimethylamine through a one-step method; bis(2-dialkylaminoethyl)ether or N,N,N,N-tetramethylhexanediamine is prepared in a high-conversion-rate and high-selectivity manner.

Synthesis of bis(2-dimethylaminoethyl) ether

A bis(2-dimethylaminoethyl) ether product is prepared by chlorinating 2-(2-(dimethylamino)ethoxy)ethanol, which is taken as a raw material, by using thionyl chloride to obtain a corresponding chloride; preparing the chloride and trimethylamine into quaternary ammonium salt; drying the obtained quaternary ammonium salt, then using ethylene diamine to enable one methyl of the quaternary ammonium salt to be transferred onto the ethylene diamine at high temperature, and rectifying.

Bis(2-dimethylaminoethyl)ether synthesis method

The invention belongs to the technical field of organic macromolecular compounds and relates to a bis(2-dimethylaminoethyl)ether synthesis method. The method includes subjecting dimethylamine and ethylene oxide to reaction in a high-pressure reactor, wherein a mole ratio is 1:2-2.2, a reaction temperature is 60-100 DEG C, reaction time is 2-5 hours, and curing time is 0.5-1 hour; adding a catalyst Cu-Ni/gamma-Al2O3, adopting hydrogen for adjusting an internal pressure of the reactor to 1.5-2.5 MPa, controlling the temperature at 190-220 DEG C, controlling a reaction pressure to be 10-25 MPa, and reacting for 6-13h; after the pressure drops to 1.0 MPa, feeding to the middle of an amine/hydrogen removal tower to discharge the dimethylamine and the hydrogen in the mixture from the top of the amine/hydrogen removal tower, and subjecting a crude product of bis(2-dimethylaminoethyl)ether at the bottom of the amine/hydrogen removal tower to reduced pressure distillation and separation. The bis(2-dimethylaminoethyl)ether synthesis method is applied to polyether preparation and has advantages of high equipment utilization rate, high preparation efficiency and the like.

Preparation method for series of polyurethane catalysts

The invention discloses a preparation method for a series of polyurethane catalysts. The preparation method comprises the following steps: SioO2 and Al2O3 with different ratios are employed as carriers, soaked in an ammonium sulfate aqueous solution, dried and roasted, and a silicon-aluminum-loaded solid acid catalyst is prepared; then a mixture of N,N-dimethyl ethanolamine and N-methyl diethanolamine is employed as a raw material, the raw materials and the silicon-aluminum-loaded solid acid catalyst accounting for 1-10% of the total weight of the raw material are added in an autoclave and a reaction is carried out; the filtrate after the reaction is subjected to rectification separation and therefore N-methyl morpholine, 2-dimethylaminoethyl ether and N,N,N'-trimethyl-N'-hydroxyethyl-bis-amino ethyl ether are obtained respectively.

Method for synthesizing bis(dimethylaminoethyl)ether under catalysis of metal catalyst

The invention discloses a method for synthesizing bis(dimethylaminoethyl)ether (BDMAEE) under the catalysis of a metal catalyst. The method comprises the following steps: preparing a metal oxide; then preparing the metal catalyst from the metal oxide; and with dimethylamine and dimethylaminoethoxyethanol as raw materials, preparing BDMAEE under the catalysis of the metal catalyst, wherein a main inorganic by-product is water, and produced organic by-products can be recycled through distillation and purification. The method provided by the invention has good economic benefits and overcomes the problem of environmental pollution of conventional BDMAEE production processes.

Method for Preparation of Bis (2-dialkyaminoethyl) Ether

A bis (2-dialkylaminoethyl) ether synthesizing method is disclosed, which includes steps of: 1) synthesizing: wherein N,N-dialkylethanolamine, N,N-dialkylamine and ethyne are mixed at a mole ratio of 4:3:1-2:1:1 as a raw material; and the raw material, catalyst and solvent are added in a high-pressure clave for reaction in a sealed condition; a weight of catalyst accounts for 2.0%-10.5% of the total weight of the raw material; a reaction temperature is 50-120° C. and the reaction time is 3-7 hours; the clave is then opened after reaction and a filtrate is collected by filtering the reaction mixture; and 2) separating: wherein the filtrate obtained in the step 1) is rectified to obtain the bis (2-dialkylaminoethyl) ether as a product. The synthetic method of the bis (2-dialkylaminoethyl) ether in the present invention has many characteristics, such as simple process, high atomic economy, etc.

Method for separating N,N,N'-trimethylbisaminoethylether and/or N,N-dimethylbisaminoethylether from a mixture

The present invention relates to a method for separating N,N,N'-trimethylbisaminoethylether and/or N,N-dimethylbisaminoethylether, from a mixture A comprising N,N,N'-trimethylbisaminoethylether, and N,N-dimethylbisaminoethylether, wherein said method comprises the steps of: (a) contacting said mixture A with an acylating agent, to form a mixture B comprising the amides of N,N,N'-trimethylbisaminoethylether and of N,N-dimethylbisaminoethylether, respectively; and (b1) separating the amide of N,N,N'-trimethylbisaminoethylether from mixture B; and (c1) recovering N,N,N'-trimethylbisaminoethylether from its amide by means of a transamidation reaction; and/or (b2) separating the amide of N,N-dimethylbisaminoethylether from mixture B; and (c2) recovering N,N-dimethylbisaminoethylether from its amide by means of a transamidation reaction.