398489-26-4Relevant articles and documents
Method for preparing aldehyde or ketone by oxidizing reaction alcohol oxide
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Paragraph 0025-0036, (2021/11/03)
The invention relates to a method for preparing aldehyde or ketone by oxidizing reaction alcohol oxide. The invention belongs to the field of medicine and chemical engineering, and particularly relates to a nitric acid and organic nitrogen oxide composition as a catalyst. The invention is prepared by the oxidation reaction of alcohol, wherein the oxidant is oxygen, and the nitric acid and organic nitrogen oxide composition are used as a catalytic system. The reaction is homogeneous reaction, and the catalytic system is simplified. The method is simple and convenient to operate, high in yield and low in cost. The invention is a very economical and simple method for preparing aldehyde or ketone from alcohol, and is suitable for industrial production.
3-nitrile methylene azetidine-1-tert-butyl carbonate preparation method
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Page/Page column 15; 17-19, (2020/02/06)
The invention discloses a 3-nitrile methylene azetidine-1-tert-butyl carbonate preparation method, which specifically comprises: 1, synthesizing 1-tert-butyl-3-glycolate; 2, synthesizing N-Boc-3-hydroxy azetidine through the 1-tert-butyl-3-glycolate obtained in the step 1; 3, synthesizing N-Boc-3-azetidinone through the N-Boc-3-hydroxy azetidinone obtained in the step 2; and 4, synthesizing 3-nitrile methylene azetidine-1-tert-butyl carbonate through the N-Boc-3-azetidinone obtained in the step 3. According to the preparation method disclosed by the invention, the existing conventional five-step synthesis process of 3-nitrile methylene azetidine-1-tert-butyl carbonate is reduced into three steps, so that the synthesis time is greatly saved, the emission of three-waste is reduced, and the process cost is reduced.
Preparation method of medicine intermediate 1 -tert-butoxycarbonyl -3 -azetidinone (by machine translation)
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Paragraph 0081-0086, (2020/07/15)
The invention relates to the technical field of organic chemistry, and concretely relates 1 - tert-butyloxycarbonyl -3 -azetidinone and a preparation method thereof. Wherein R1 Is C1 - C6 Alkyl groups and R2 And R3 Is H or C1 - C6 The alkyl group and the acid are organic acids or inorganic acids. The method is high in relative yield and high in industrial amplification production applicability. (by machine translation)