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41317-15-1

41317-15-1

Identification

  • Product Name:Benzenamine,4-methoxy-2-methyl-N-phenyl-

  • CAS Number: 41317-15-1

  • EINECS:255-310-0

  • Molecular Weight:213.279

  • Molecular Formula: C14H15NO

  • HS Code:2922299090

  • Mol File:41317-15-1.mol

Synonyms:p-Anisidine,2-methyl-N-phenyl- (6CI);2-Methyl-4-methoxydiphenylamine;3-Methoxy-6-anilinotoluene;4-Methoxy-2-methyl-N-phenylaniline;4-Methoxy-2-methyldiphenylamine;6-Anilino-3-methoxytoluene;N-(2-Methyl-4-methoxyphenyl)aniline;

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Safety information and MSDS view more

  • Pictogram(s):Xn

  • Hazard Codes:Xn

  • Signal Word:Warning

  • Hazard Statement:H315 Causes skin irritationH319 Causes serious eye irritation

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
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  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:TRC
  • Product Description:4-Methoxy-2-methyldiphenylamine
  • Packaging:500mg
  • Price:$ 60
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:TCI Chemical
  • Product Description:4-Methoxy-2-methyldiphenylamine >97.0%(GC)
  • Packaging:500g
  • Price:$ 279
  • Delivery:In stock
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  • Manufacture/Brand:TCI Chemical
  • Product Description:4-Methoxy-2-methyldiphenylamine >97.0%(GC)
  • Packaging:25g
  • Price:$ 41
  • Delivery:In stock
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  • Manufacture/Brand:Crysdot
  • Product Description:4-Methoxy-2-methyl-N-phenylaniline 97%
  • Packaging:1000g
  • Price:$ 407
  • Delivery:In stock
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  • Manufacture/Brand:Biorbyt Ltd
  • Product Description:MMD
  • Packaging:10 μg
  • Price:$ 290.7
  • Delivery:In stock
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  • Manufacture/Brand:American Custom Chemicals Corporation
  • Product Description:4-METHOXY-2-METHYL DIPHENYLAMINE 95.00%
  • Packaging:10G
  • Price:$ 1334.03
  • Delivery:In stock
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Relevant articles and documentsAll total 16 Articles be found

Synthesis of 2-methyl-4-methoxydiphenylamine by palladium catalyzed C-N coupling - High synthetic versatility by use of a flexible catalytic system

Scholz, Ulrich,Schlummer, Bj?rn

, p. 6379 - 6385 (2005)

The synthetic versatility of the Buchwald-Hartwig Amination is demonstrated by the synthesis of the industrially important intermediate 2-methyl-4-methoxydiphenylamine. Using four routes differing in the choice of the starting materials, the diarylamine could be synthesized in excellent yields, however, each reaction required a different combination of ligand, base and solvent. This new approach is compared to established industrial routes.

A terphenyl phosphine as a highly efficient ligand for palladium-catalysed amination of aryl halides with 1° anilines

Shi, Ji-cheng,Zhang, Lixue,Zhou, Fabin

, p. 238 - 243 (2021/09/07)

A terphenyl phosphine ligand (2,6-bis(2,4,6-triisopropylphenyl)phenyl-dicyclohexylphosphine, TXPhos) and its supported palladium complex [(TXPhos)(allyl)PdCl] have been developed and the catalyst system is highly efficient in amination of aryl halides with 1° anilines, especially effective for densely functionalized substrates including both partners possessing ortho-ester, acetyl, nitrile and nitro groups. With the TXPhos-supported catalyst system, many partner combinations have been unprecedentedly realized and the base scope has been even extended to KOAc, which is even the best choice in the amination of 2-nitrochlorobenzene.

Preparation method and application of 2-methyl-4-methoxydiphenylamine

-

Paragraph 0070-0098, (2021/06/23)

The invention relates to the field of preparation of diphenylamine, in particular to a preparation method and application of 2-methyl-4-methoxydiphenylamine, and the preparation method of the 2-methyl-4-methoxydiphenylamine comprises the following steps: (1) in a solvent, reacting 2-methyl-4-methoxyaniline with halogenated benzoic acid in the presence of a catalyst and an acid-binding agent to obtain a condensation product, wherein the acid-binding agent is selected from one or more of carbonate, phosphate and hydroxide of alkali metal; (2) acidifying the condensation product, and conducting filtering, washing and drying to obtain a product 1; and (3) decarboxylating the product 1, and conducting purifying to obtain the product 1. The preparation method of the 2-methyl-4-methoxydiphenylamine is convenient to operate, short in time and suitable for large-scale production, and the production efficiency is greatly improved.

Preparation method of secondary aromatic amine

-

Paragraph 0024, (2021/03/31)

The invention provides a method for preparing secondary aromatic amine by performing a palladium-catalyzed C-N coupling reaction on (pseudo)aryl halide and (pseudo)heterocyclic aryl halide and primary(heterocyclic)aromatic amine. The method is characterized in that an alkali for promoting the reaction is an alkali metal carboxylate or an alkali metal bicarbonate.

Synthesis method of DPA

-

Paragraph 0007, (2020/01/25)

The invention discloses a synthesis method of DPA. The method comprises the following steps: (1) adding methanol, o-nitrotoluene, a catalyst, concentrated sulfuric acid, distilled water into an autoclave, performing heating with stirring to 50 DEG C, evacuating air and then introducing hydrogen, controlling a pressure in the autoclave to 0.1 MPa, carrying out a reaction for 5 h, then performing suction filtration, distilling a filtrate to remove methanol, diluting a residual solution by adding water and then adjusting pH to be neutral with ammonia water, performing extracting with toluene, washing an organic phase with a dilute sodium hydroxide solution, and performing reduced pressure distillation on the organic phase to obtain 4-methoxy-2-methylaniline; and (2) adding 4-methoxy-2-methylaniline, phenol naphthalene, cyclohexanone, and the catalyst into an autoclave, replacing air with nitrogen, performing heating to 250 DEG C, controlling a pressure in the autoclave to 1 Mpa, performing cooling to room temperature after a reaction is completed, filtering a reaction solution, and performing reduced pressure distillation on a filtrate and collecting various fractions, wherein a latter fraction is DPA. The raw materials are cheap and easy to obtain, the operation is simple, the yield is high, the energy consumption is low, and the method has practical value and economic value, andis suitable for enterprise production.

Synthetic method of -4- 2- methyl-methoxyl diphenylamine (by machine translation)

-

Paragraph 0022-0035, (2019/11/29)

After the reaction is finished, the 2 - organic phase is extracted with DMF toluene, concentrated, vacuum-dried (1) to obtain the intermediate product, (2) and the obtained intermediate product is evaporated and decarboxylated in a methanol system 10~20min 2 - 6~10h 2 . To the synthesis method, the reaction conversion efficiency and selectivity are improved, the raw material conversion rate is improved, the produced process wastewater is less, and the production cost is low. (by machine translation)

Process route upstream and downstream products

Process route

bromobenzene
108-86-1,52753-63-6

bromobenzene

2-methyl-4-methoxyaniline
102-50-1

2-methyl-4-methoxyaniline

4-phenylamino-3-methyl-1-methoxybenzene
41317-15-1

4-phenylamino-3-methyl-1-methoxybenzene

Conditions
Conditions Yield
With caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris(dibenzylideneacetone)dipalladium (0); In toluene; at 110 ℃;
95%
With 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium(0); In toluene; Heating;
95%
With potassium phosphate; copper(l) iodide; C18H15N3O2; at 25 ℃; for 24h; Reagent/catalyst; Temperature; Sealed tube;
93%
With potassium phosphate; copper(l) iodide; In diethylene glycol; at 70 ℃; for 14h; Sealed tube;
93%
methanol
67-56-1

methanol

1-methyl-2-nitrobenzene
88-72-2

1-methyl-2-nitrobenzene

4-phenylamino-3-methyl-1-methoxybenzene
41317-15-1

4-phenylamino-3-methyl-1-methoxybenzene

Conditions
Conditions Yield
methanol; 1-methyl-2-nitrobenzene; With 3 % platinum on carbon; hydrogen; In water; at 50 ℃; for 8h; under 750.075 Torr; Autoclave; Inert atmosphere;
phenol; With 3 % platinum on carbon; In cyclohexanone; at 250 ℃; for 2h; under 7500.75 Torr; Autoclave; Inert atmosphere;
95.4%
phenylhydrazine
100-63-0

phenylhydrazine

2-methyl-4-methoxyaniline
102-50-1

2-methyl-4-methoxyaniline

4-phenylamino-3-methyl-1-methoxybenzene
41317-15-1

4-phenylamino-3-methyl-1-methoxybenzene

Conditions
Conditions Yield
With cobalt(II) phthalocyanine; copper(l) chloride; In dichloromethane; at 10 ℃;
86%
4-bromo-3-methylanisole
27060-75-9

4-bromo-3-methylanisole

Acetanilid
103-84-4

Acetanilid

4-phenylamino-3-methyl-1-methoxybenzene
41317-15-1

4-phenylamino-3-methyl-1-methoxybenzene

Conditions
Conditions Yield
Acetanilid; With sodium methylate; In 1-methyl-pyrrolidin-2-one; at 100 ℃;
4-bromo-3-methylanisole; In 1-methyl-pyrrolidin-2-one; at 20 - 40 ℃; for 1.25h;
In 1-methyl-pyrrolidin-2-one; methanol; at 100 ℃; for 1h; Reagent/catalyst; Temperature; Solvent;
95.3%
2-(4-methoxy-2-methylphenylamino)benzoic acid

2-(4-methoxy-2-methylphenylamino)benzoic acid

4-phenylamino-3-methyl-1-methoxybenzene
41317-15-1

4-phenylamino-3-methyl-1-methoxybenzene

Conditions
Conditions Yield
With methanol; Reagent/catalyst;
90.99%
In methanol; at 60 - 180 ℃; for 20h; Sealed tube; Large scale;
85.6%
chlorobenzene
108-90-7

chlorobenzene

2-methyl-4-methoxyaniline
102-50-1

2-methyl-4-methoxyaniline

4-phenylamino-3-methyl-1-methoxybenzene
41317-15-1

4-phenylamino-3-methyl-1-methoxybenzene

Conditions
Conditions Yield
With C50H72ClPPd; 2,6-bis(2,4,6-triisopropylphenyl)phenyldicyclohexylphosphine; potassium carbonate; In tert-butyl alcohol; at 100 ℃; for 3h;
99%
With potassium phosphate; DavePhos; tris(dibenzylideneacetone)dipalladium (0); In toluene; at 110 ℃; for 8h;
95%
With potassium phosphate; DavePhos; tris-(dibenzylideneacetone)dipalladium(0); In toluene; Heating;
95%
1-chloro-4-methoxy-2-methylbenzene
13334-71-9

1-chloro-4-methoxy-2-methylbenzene

aniline
62-53-3

aniline

4-phenylamino-3-methyl-1-methoxybenzene
41317-15-1

4-phenylamino-3-methyl-1-methoxybenzene

Conditions
Conditions Yield
With potassium phosphate; aniline; triphenylphosphine; tris(dibenzylideneacetone)dipalladium (0); at 184 ℃; for 8h;
96%
With potassium phosphate; DavePhos; tris-(dibenzylideneacetone)dipalladium(0); at 184 ℃;
96%
bromobenzene
108-86-1,52753-63-6

bromobenzene

4-methoxy-aniline
104-94-9

4-methoxy-aniline

4-phenylamino-3-methyl-1-methoxybenzene
41317-15-1

4-phenylamino-3-methyl-1-methoxybenzene

Conditions
Conditions Yield
With C50H72ClPPd; 2,6-bis(2,4,6-triisopropylphenyl)phenyldicyclohexylphosphine; potassium carbonate; In tert-butyl alcohol; at 100 ℃; for 3h;
96%
2-methyl-4-methoxyaniline
102-50-1

2-methyl-4-methoxyaniline

ortho-chlorobenzoic acid
118-91-2

ortho-chlorobenzoic acid

4-phenylamino-3-methyl-1-methoxybenzene
41317-15-1

4-phenylamino-3-methyl-1-methoxybenzene

Conditions
Conditions Yield
2-methyl-4-methoxyaniline; ortho-chlorobenzoic acid; With potassium phosphate tribasic trihydrate; sodium carbonate; copper dichloride; In toluene; at 110 ℃; for 5h;
With N-Methylformamide; In toluene; at 50 - 180 ℃; for 8h; Reagent/catalyst; Temperature;
iodobenzene
591-50-4

iodobenzene

4-methoxy-aniline
104-94-9

4-methoxy-aniline

4-phenylamino-3-methyl-1-methoxybenzene
41317-15-1

4-phenylamino-3-methyl-1-methoxybenzene

Conditions
Conditions Yield
With C50H72ClPPd; 2,6-bis(2,4,6-triisopropylphenyl)phenyldicyclohexylphosphine; potassium carbonate; In tert-butyl alcohol; at 100 ℃; for 6h;
57%

Global suppliers and manufacturers

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  • Chemwill Asia Co., Ltd.
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  • Amadis Chemical Co., Ltd.
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  • Contact Tel:86-571-89925085
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  • Main Products:29
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  • Shaanxi BLOOM TECH Co.,Ltd
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  • Shanghai Upbio Tech Co.,Ltd
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