52411-34-4Relevant articles and documents
Diaryl-substituted polyethers with acetoacet-anilide fragment in the synthesis of dihydro-pyrimidine-containing podands
Radionova,Titova, Yu. A.,Isenov,Fedorova,Rusinov,Charushin
, p. 998 - 1004 (2014)
The interaction of ortho-aminoaryl polyethers, derivatives of mono-, di-, and triethylene glycol, with acetyl ketene, generated from 2,2,6-trimethyl-4H-1,3-dioxin-4-one produced acetoacetanilide- containing podands. 2,2,6-Trimethyl-4H-1,3-dioxin-4-one reacted with aminoaryl-substituted podands containing a short polyether chain (1-2 atoms) in toluene medium without catalyst. Acetoacetanilide- containing podands with longer polyether chains could be obtained by using triethylamine or acetic acid as catalyst. Acetoacetanilide-containing podands were used in the Biginelli reaction as CH-active components.
Long-Term Tracking and Dynamically Quantifying of Reversible Changes of Extracellular Ca2+ in Multiple Brain Regions of Freely Moving Animals
Liu, Yuandong,Liu, Zhichao,Zhao, Fan,Tian, Yang
, p. 14429 - 14437 (2021/05/03)
Understanding physiological and pathological processes in the brain requires tracking the reversible changes in chemical signals with long-term stability. We developed a new anti-biofouling microfiber array to real-time quantify extracellular Ca2+ concentrations together with neuron activity across many regions in the mammalian brain for 60 days, in which the signal degradation was 2+ upon ischemia-reperfusion processes. The changing sequence and rate of Ca2+ in 7 brain regions were different during the stroke. ROS scavenger could protect Ca2+ influx and neuronal activity after stroke, suggesting the significant influence of ROS on Ca2+ overload and neuron death. We demonstrated this microarray is a versatile tool for investigating brain dynamic during pathological processes and drug treatment.
A Comprehensive Study of the Ca2+ Ion Binding of Fluorescently Labelled BAPTA Analogues
Csomos, Attila,Kontra, Bence,Jancsó, Attila,Galbács, Gábor,Deme, Ruth,Kele, Zoltán,Rózsa, Balázs József,Kovács, Ervin,Mucsi, Zoltán
, p. 5248 - 5261 (2021/10/19)
Since its development, the ionophore BAPTA (1,2-bis(2-aminophenoxy)-ethane-N,N,N’,N’-tetraacetic acid) has been used unchanged in calcium sensing applications. In this work we present a comprehensive experimental and theoretical study of novel alterations in the structure of BAPTA, with a focus on the systematic modification of the chain connecting the two aromatic rings of the molecule (denoted as “linker”). A bis-(diethylamino)xantene fluorophore was also attached to the structures in a fixed position and the structure-fluorescence response relationship of these molecules was investigated in addition. The effect of the linker's length, the number of oxygen atoms in this chain and even the removal of one of the rings was tested; these all proved to significantly alter the characteristics of the compounds. For example, it was found that the second aromatic ring of BAPTA is not essential for the turn-on of the fluorescence. We also demonstrated that successful sensing can be realized even by replacing the chain with a single oxygen atom, which suggests the availability of a new calcium binding mode of the chelator. The reliable turn-on characteristic, the steep Ca2+ fluorescence titration curve and the intense fluorescence emission combine to make this compound a prospective candidate as a calcium sensing molecular probe in diagnostic neurobiological applications.
[18F] Fluoride Cryptate Complexes for Radiolabeling Fluorinations
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, (2020/01/12)
The present invention claims UV detectable (λ>210 nm) potassium [18F]fluoride diaryl- and aryl-fused [2.2.2]cryptate complexes suitable for performing radio-labeling reactions to generate [18F] fluorinated species.
A Copper Nanocluster-Based Fluorescent Probe for Real-Time Imaging and Ratiometric Biosensing of Calcium Ions in Neurons
Liu, Zhichao,Jing, Xia,Zhang, Sanjun,Tian, Yang
, p. 2488 - 2497 (2019/02/12)
Fluorescent calcium ion (Ca2+) sensing and imaging have become an essential technique for investigation of signaling pathways of Ca2+ and understanding the role of Ca2+ in neurodegenerative disease. Herein a copper nanocluster (CuNC)-based ratiometric fluorescent probe was developed for real-time sensing and imaging of Ca2+ in neurons, in which a specific Ca2+ ligand with two formaldehyde groups was synthesized and further conjugated with polyethylenimine (PEI) to form a new ligand molecule for the synthesis of CuNCs. Meanwhile, water-soluble Alex Fluor 660 NHS ester was immobilized onto CuNCs as a reference element. The developed ratiometric fluorescence nanoprobe demonstrated a good linearity with Ca2+ concentration in the range of 2-350 μM, and a detection limit down to 220 ± 11 nM was achieved. In addition, the response time of the present probe for Ca2+ was found to be less than 2 s with good stability and high selectivity. Taking advantage of the low cytotoxicity and good biocompatibility of the developed nanoprobe, it was discovered that the histamine-induced cytoplasmic Ca2+ increase in various parts of neurons was different. Moreover, it was found O2--induced cytoplasmic Ca2+ burst and O2--induced neuronal death possibly resulted from Ca2+ overload in the neurons.
DISAZO YELLOW PIGMENT, PIGMENTS DISPERSION AND PHOTOSENSITIVE RESIN COMPOSITION USING THE SAME
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, (2019/06/11)
Novel pigment yellow formation of pigment dispersion including oh settlement compound and disclosure photosensitive resin composition are disclosed. Said discharge oh settlement compounds are high heat resistance and excellent dispersion property, the dispersion of pigment dispersion including same on the base and storage stability. The, said discharge oh settlement using the photosensitive resin compositions have a good coloring compounds including pigment dispersion can be implementing force, such as a high-quality color filter having an excellent optical brightness and contrast can be [...] number. (by machine translation)
[18F] fluoride cryptate complexes for radiolabeling fluorinations
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, (2018/09/11)
The present invention claims UV detectable (λ>210 nm) potassium [18F]fluoride diaryl- and aryl-fused [2.2.2]cryptate complexes suitable for performing radio-labeling reactions to generate [18F] fluorinated species.
Polylactic acid composition
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, (2017/06/02)
A resin composition which comprises polylactic acid, does not release an isocyanate group at the time of production and has excellent hydrolysis resistance and a low environmental burden. The resin composition comprises: (A) 100 parts by weight of a resin component (component A) containing polylactic acid (component A-α);(B) 0.001 to 10 parts by weight of a compound (component B) having one carbodiimide group and a cyclic structure in which first nitrogen and second nitrogen are bonded to each other via a bonding group, the cyclic structure consisting of 8 to 50 atoms; and(C) 0.001 to 2 parts by weight of at least one antioxidant (component C) selected from the group consisting of a hindered phenol-based compound, a phosphite-based compound, a phosphonite-based compound and a thioether-based compound.
Real-Time Reaction Monitoring of an Organic Multistep Reaction by Electrospray Ionization-Ion Mobility Spectrometry
Zühlke, Martin,Sass, Stephan,Riebe, Daniel,Beitz, Toralf,L?hmannsr?ben, Hans-Gerd
, p. 1266 - 1273 (2017/11/15)
The capability of electrospray ionization (ESI)-ion mobility (IM) spectrometry for reaction monitoring is assessed both as a stand-alone real-time technique and in combination with HPLC. A three-step chemical reaction, consisting of a Williamson ether synthesis followed by a hydrogenation and an N-alkylation step, is chosen for demonstration. Intermediates and products are determined with a drift time to mass-per-charge correlation. Addition of an HPLC column to the setup increases the separation power and allows the determination of further species. Monitoring of the intensities of the various species over the reaction time allows the detection of the end of reaction, determination of the rate-limiting step, observation of the system response in discontinuous processes, and optimization of the mass ratios of the starting materials. However, charge competition in ESI influences the quantitative detection of substances in the reaction mixture. Therefore, two different methods are investigated, which allow the quantification and investigation of reaction kinetics. The first method is based on the pre-separation of the compounds on an HPLC column and their subsequent individual detection in the ESI-IM spectrometer. The second method involves an extended calibration procedure, which considers charge competition effects and facilitates nearly real-time quantification.
Method using sodium hydrosulfide to prepare 2, 2'-(Ethylenedioxy)dianiline through reduction
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Paragraph 0023; 0024, (2016/12/01)
The invention discloses a method using sodium hydrosulfide to prepare 2, 2'-(Ethylenedioxy)dianiline through reduction. The method includes: adding 1, 2-bis(2-nitrophenoxy)ethane, water and sodium hydrosulfide aqueous solution into a high-pressure kettle, feeding nitrogen for replacement, heating, controlling reaction pressure to be 0-0.5Mpa and reaction temperature to be 100-140 DEG C, keeping the temperature for 2-6 hours, and finishing the reaction; discharging pressure and cooling after the reaction, and filtering at 30-35 DEG C to obtain a crude product; using water as the solvent of the crude product, and performing acid dissolution, alkaline reverse adjusting refining and drying to obtain a qualified product. The method has the advantages that the water is used as the solvent, organic solvents such alcohol are not used, reaction yield is larger than 90%, product purity is larger than 99.5%, the waste water generated by the reduction only contains sodium hydrosulfide and sodium thiosulfate, the sodium hydrosulfide is turned into the sodium thiosulfate through oxidizing, the sodium thiosulfate can be reused after water is steamed out, and the method is green, low in equipment requirement and low in investment.
