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Cas Database

79-03-8

79-03-8

Identification

  • Product Name:Propionyl chloride

  • CAS Number: 79-03-8

  • EINECS:201-170-0

  • Molecular Weight:92.5251

  • Molecular Formula: C3H5ClO

  • HS Code:2915.90

  • Mol File:79-03-8.mol

Synonyms:Propionylchloride (6CI,8CI);Chloro ethyl ketone;NSC 83547;Propionic acid chloride;

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Safety information and MSDS view more

  • Pictogram(s):FlammableF, CorrosiveC

  • Hazard Codes:F,C

  • Signal Word:Danger

  • Hazard Statement:H225 Highly flammable liquid and vapourH314 Causes severe skin burns and eye damage

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]: May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution. (ERG, 2016)

  • Fire-fighting measures: Suitable extinguishing media Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]: Some of these materials may react violently with water. SMALL FIRE: Dry chemical, CO2, water spray or alcohol-resistant foam. LARGE FIRE: Water spray, fog or alcohol-resistant foam. Move containers from fire area if you can do it without risk. Dike fire-control water for later disposal; do not scatter the material. Do not get water inside containers. FIRE INVOLVING TANKS OR CAR/TRAILER LOADS: Fight fire from maximum distance or use unmanned hose holders or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks engulfed in fire. For massive fire, use unmanned hose holders or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2016) Excerpt from ERG Guide 132 [Flammable Liquids - Corrosive]: Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. (ERG, 2016) Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

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  • Manufacture/Brand:TCI Chemical
  • Product Description:Propionyl Chloride >98.0%(GC)(T)
  • Packaging:25g
  • Price:$ 25
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  • Manufacture/Brand:TCI Chemical
  • Product Description:Propionyl Chloride >98.0%(GC)(T)
  • Packaging:500g
  • Price:$ 44
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Propionyl chloride for synthesis
  • Packaging:500 mL
  • Price:$ 52.35
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Propionyl chloride for synthesis. CAS No. 79-03-8, EC Number 201-170-0., for synthesis
  • Packaging:8070630500
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Propionyl chloride 98%
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Propionyl chloride for synthesis. CAS No. 79-03-8, EC Number 201-170-0., for synthesis
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  • Manufacture/Brand:Sigma-Aldrich
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Propionyl chloride 98%
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Relevant articles and documentsAll total 111 Articles be found

Photo-on-Demand Synthesis of Vilsmeier Reagents with Chloroform and Their Applications to One-Pot Organic Syntheses

Liang, Fengying,Eda, Kazuo,Okazoe, Takashi,Wada, Akihiro,Mori, Nobuaki,Konishi, Katsuhiko,Tsuda, Akihiko

, p. 6504 - 6517 (2021/05/06)

The Vilsmeier reagent (VR), first reported a century ago, is a versatile reagent in a variety of organic reactions. It is used extensively in formylation reactions. However, the synthesis of VR generally requires highly toxic and corrosive reagents such as POCl3, SOCl2, or COCl2. In this study, we found that VR is readily obtained from a CHCl3 solution containing N,N-dimethylformamide or N,N-dimethylacetamide upon photo-irradiation under O2 bubbling. The corresponding Vilsmeier reagents were obtained in high yields with the generation of gaseous HCl and CO2 as byproducts to allow their isolations as crystalline solid products amenable to analysis by X-ray crystallography. With the advantage of using CHCl3, which bifunctionally serves as a reactant and a solvent, this photo-on-demand VR synthesis is available for one-pot syntheses of aldehydes, acid chlorides, formates, ketones, esters, and amides.

Rhodium(III)-catalyzed chemodivergent annulations between phenyloxazoles and diazos via C–H activation

Zhang, Xueguo,Wang, Peigen,Zhu, Liangwei,Chen, Baohua

supporting information, p. 695 - 699 (2020/06/28)

Acid-controlled, chemodivergent and redox-neutral annulations for the synthesis of isocoumarins and isoquinolinones have been realized via Rh(III)-catalyzed C[sbnd]H activation. Diazo compounds act as a carbene precursor, and coupling occurs in one-pot process, where adipic acid and trimethylacetic acid promote chemodivergent cyclizations.

Synthesis, experimental and theoretical study of novel 2-haloalkyl (-CF2H, -CCl2H, -CF2CF3)-, 3-bromo and bromomethyl substituted chromones

Narváez O, Ena G.,Bonilla V., Pablo M.,Zurita, Daniel A.,Alcívar L., Christian D.,Heredia-Moya, Jorge,Ulic, Sonia E.,Jios, Jorge L.,Piro, Oscar E.,Echeverría, Gustavo A.,Langer, Peter

, (2021/01/12)

A set of seven new chromones with 2-haloalkyl (-CF2H, -CCl2H, -CF2CF3) and 3-bromo and bromomethyl substituents were synthesized. The novel compounds were studied by DFT calculations and characterized by vibrational spectroscopy (IR and Raman) in solid state, and NMR (1H, 13C and 19F) and UV–vis spectroscopy in solution. The crystal structure of 3-dibromomethyl-2-difluoromethyl chromone was determined by X-ray diffraction. Due to extended π-bond delocalization, the organic framework is planar and lies on a crystallographic m-mirror plane. The intermolecular non-covalent interactions of 3-dibromomethyl-2-difluoromethyl chromone, as π?π stacking arrangements, F?H hydrogen bonds and O?Br contacts were evaluated by Hirshfeld surfaces analysis. These intermolecular contacts, which affect the absorption bands location of the involved groups, were also detected in the vibrational spectra.

Electrodimerization ofN-Alkoxyamides for the Synthesis of Hydrazines

Nasier, Abudulajiang,Chang, Xihao,Guo, Chang

, p. 16068 - 16076 (2021/09/18)

An efficient and valuable N-N dimerization reaction ofN-alkoxyamides is reported under undivided electrolytic conditions. This electrochemical strategy provides a powerful way to access a wide range of advanced, highly functionalized hydrazines. Remarkably, anN-centered radical generated from the cleavage of the N-H bond under electrolytic conditions plays a crucial role in this transformation. Furthermore, variousN-alkoxyamides bearing different substituents are suitable in this transformation, furnishing the corresponding hydrazines in up to 92% yield.

Neutrophil-Selective Fluorescent Probe Development through Metabolism-Oriented Live-Cell Distinction

Gao, Min,Lee, Sun Hyeok,Park, Sang Hyuk,Ciaramicoli, Larissa Miasiro,Kwon, Haw-Young,Cho, Heewon,Jeong, Joseph,Chang, Young-Tae

supporting information, p. 23743 - 23749 (2021/10/14)

Human neutrophils are the most abundant leukocytes and have been considered as the first line of defence in the innate immune system. Selective imaging of live neutrophils will facilitate the in situ study of neutrophils in infection or inflammation events as well as clinical diagnosis. However, small-molecule-based probes for the discrimination of live neutrophils among different granulocytes in human blood have yet to be reported. Herein, we report the first fluorescent probe NeutropG for the specific distinction and imaging of active neutrophils. The selective staining mechanism of NeutropG is elucidated as metabolism-oriented live-cell distinction (MOLD) through lipid droplet biogenesis with the help of ACSL and DGAT. Finally, NeutropG is applied to accurately quantify neutrophil levels in fresh blood samples by showing a high correlation with the current clinical method.

Process route upstream and downstream products

Process route

3,3-dichloro-1,2-diphenylcyclopropene
2570-00-5

3,3-dichloro-1,2-diphenylcyclopropene

propionic acid
802294-64-0,79-09-4

propionic acid

propionyl chloride
79-03-8

propionyl chloride

diphenylcyclopropenone
886-38-4

diphenylcyclopropenone

Conditions
Conditions Yield
In chloroform-d1; for 0.25h; Inert atmosphere;
pentan-3-one
96-22-0

pentan-3-one

2-chloro-3-pentanone
17042-21-6

2-chloro-3-pentanone

1-chloro-3-pentanone
32830-97-0

1-chloro-3-pentanone

propionyl chloride
79-03-8

propionyl chloride

acetaldehyde
75-07-0,9002-91-9

acetaldehyde

Conditions
Conditions Yield
With chlorine; at 23.84 ℃; under 830 - 980 Torr; UV-irradiation;
pentan-3-one
96-22-0

pentan-3-one

2-chloro-3-pentanone
17042-21-6

2-chloro-3-pentanone

1-chloro-3-pentanone
32830-97-0

1-chloro-3-pentanone

2,3-Pentanedione
600-14-6

2,3-Pentanedione

propionyl chloride
79-03-8

propionyl chloride

acetaldehyde
75-07-0,9002-91-9

acetaldehyde

Conditions
Conditions Yield
With oxygen; chlorine; at 23.84 ℃; under 830 - 980 Torr; UV-irradiation;
pentan-3-one
96-22-0

pentan-3-one

2-chloro-3-pentanone
17042-21-6

2-chloro-3-pentanone

1-chloro-3-pentanone
32830-97-0

1-chloro-3-pentanone

4-penten-3-one
1629-58-9

4-penten-3-one

propionyl chloride
79-03-8

propionyl chloride

acetaldehyde
75-07-0,9002-91-9

acetaldehyde

Conditions
Conditions Yield
With oxygen; chlorine; at 236.84 ℃; under 700 - 950 Torr; UV-irradiation;
propionic acid
802294-64-0,79-09-4

propionic acid

propionyl chloride
79-03-8

propionyl chloride

Conditions
Conditions Yield
With thionyl chloride; In N,N-dimethyl-formamide; at 70 - 75 ℃;
97%
With N,N-dimethyl-formamide; trichlorophosphate; at 100 ℃;
93.7%
propionic acid; With chloroform; oxygen; N,N-dimethyl-formamide; at 30 ℃; for 3h; Irradiation;
at 30 ℃; for 2h;
86%
With phosphorus trichloride;
With phosphorus pentachloride;
With thionyl chloride;
With phosphorus pentachloride;
With phosphorus trichloride;
With disulfur dichloride; chlorine;
With tetrachlorosilane; xylene; at 50 ℃;
With hydrogenchloride; acetonitrile; at 0 ℃;
With thionyl chloride; In tetrachloromethane; at 65 ℃;
With thionyl chloride; Heating;
With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide;
With thionyl chloride; In various solvent(s); at 60 ℃; Rate constant; Kinetics; Thermodynamic data; activation energy (E); var. temp.;
With thionyl chloride; for 3h; Heating;
With PS-Ph3P resin; trichloroacetonitrile; In dichloromethane; at 20 ℃;
With thionyl chloride; In dichloromethane;
With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide;
With thionyl chloride; In benzene; for 6h; Heating;
With thionyl chloride; for 4h; Reflux;
With thionyl chloride; at 85 ℃; for 0.25h;
With thionyl chloride; Reflux;
With oxalyl dichloride; In dichloromethane;
With thionyl chloride; Reflux;
With thionyl chloride; In ISOPROPYLAMIDE; at 0 ℃;
With oxalyl dichloride;
With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 - 20 ℃;
With trichloroacetonitrile; triphenylphosphine; In acetonitrile; at 20 ℃; Inert atmosphere;
With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 0.5h;
With thionyl chloride; In dichloromethane; for 1h; Reflux;
With thionyl chloride;
With thionyl chloride; at 60 ℃; for 3.5h;
With thionyl chloride; at 20 - 80 ℃; for 3.66667h;
With thionyl chloride; for 2h; Heating;
With bis(trichloromethyl) carbonate; at 40 ℃; for 3h;
With oxalyl dichloride; In dichloromethane; for 3h;
With thionyl chloride;
With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 - 20 ℃; for 1.5h;
With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 1h;
With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 23 ℃; for 3h;
With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; at 0 - 20 ℃; for 2.33333h;
With thionyl chloride; In N,N-dimethyl-formamide; at 70 ℃; for 1.5h;
With oxalyl dichloride; In dichloromethane;
With thionyl chloride; In N,N-dimethyl-formamide; at 70 ℃;
With oxalyl dichloride; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;
With oxalyl dichloride; In dichloromethane; at 0 - 20 ℃;
With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 2h;
With trichlorophosphate; at -20 ℃;
With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; Inert atmosphere;
With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 - 20 ℃; for 3h; Inert atmosphere;
With oxalyl dichloride;
With phosphorus trichloride; at 60 - 70 ℃;
With thionyl chloride; In dichloromethane; for 1h; Reflux;
With thionyl chloride; In dichloromethane; Reflux;
With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; Inert atmosphere;
With thionyl chloride; for 3h; Cooling with ice; Reflux;
With thionyl chloride; at 60 ℃; for 3h;
With thionyl chloride; at 60 ℃; for 3h;
With thionyl chloride; at 60 ℃; for 3h;
With thionyl chloride; at 60 ℃; for 3h;
With oxalyl dichloride; In dichloromethane; at 20 ℃; Inert atmosphere;
With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 24 ℃; Inert atmosphere;
With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 ℃; for 0.25h;
With oxalyl dichloride; In dichloromethane; at 0 ℃; for 0.25h; Inert atmosphere;
With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; for 2h;
With oxalyl dichloride; In chloroform; N,N-dimethyl-formamide; at 80 ℃; for 3h;
With thionyl chloride; at 60 ℃; for 3h;
With thionyl chloride; In dichloromethane; for 6h; Reflux;
With oxalyl dichloride; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;
With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 - 40 ℃; for 10h;
With oxalyl dichloride; N,N-dimethyl-formamide; at 0 - 20 ℃;
With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; for 2h;
With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 2h;
With oxalyl dichloride;
With benzoyl chloride; at 20 - 130 ℃; for 2h;
With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃;
With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 - 20 ℃; for 2h;
With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 - 20 ℃;
With thionyl chloride; at 85 ℃; for 3h; Inert atmosphere;
propionaldehyde
123-38-6

propionaldehyde

propionyl chloride
79-03-8

propionyl chloride

Conditions
Conditions Yield
With trichloroisocyanuric acid; In dichloromethane; at 20 ℃; Inert atmosphere;
With trichloroisocyanuric acid; In dichloromethane; at 20 ℃; Inert atmosphere;
propionic acid
802294-64-0,79-09-4

propionic acid

propionyl chloride
79-03-8

propionyl chloride

propionic acid anhydride
123-62-6

propionic acid anhydride

Conditions
Conditions Yield
With phosphorus trichloride; at 40 - 50 ℃; 4-5h;
57.9%
With phosphorus trichloride; at 40 - 50 ℃; 4-5h;
46.4%
18%
benzoyl chloride
98-88-4

benzoyl chloride

propionic acid
802294-64-0,79-09-4

propionic acid

propionyl chloride
79-03-8

propionyl chloride

Conditions
Conditions Yield
3,4-dichloro-(E)-3-hexene
51430-68-3

3,4-dichloro-(E)-3-hexene

propionyl chloride
79-03-8

propionyl chloride

1,1-Dichlorpropylhydroperoxid
100220-04-0

1,1-Dichlorpropylhydroperoxid

Conditions
Conditions Yield
With hydrogenchloride; ozone; formic acid ethyl ester; at -10 - 0 ℃;
trimethylsilyl propionate
16844-98-7

trimethylsilyl propionate

chlorosulfonate de trimethylsilyle
4353-77-9

chlorosulfonate de trimethylsilyle

propionyl chloride
79-03-8

propionyl chloride

trimethylsilyl 1-<(trimethylsiloxy)carbonyl>ethanesulfonate
86521-60-0

trimethylsilyl 1-<(trimethylsiloxy)carbonyl>ethanesulfonate

Conditions
Conditions Yield
In 1,2-dichloro-ethane; for 12h; Mechanism; Heating; course is discussed; further trimethylsilyl carboxylates, aldehydes and ketones;
41%
In 1,2-dichloro-ethane; for 12h; Heating;
41%

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