Synthesis and structure-activity relationships of novel 2',2'-difluoro analogues of docetaxel

DOI: 10.1248/cpb.45.1793

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1793 - 1804 (1997)

Update date:2022-08-03

Topics: Synthesis Mass spectrometry Structure-activity relationships In vitro Testing In Vivo Testing Gas Chromatography

Authors:

Uoto, Kouichi

Ohsuki, Satoru

Takenoshita, Haruhiro

Ishiyama, Takashi

Iimura, Shin

Hirota, Yasuhide

Mitsui, Ikuo

Terasawa, Hirofumi

Soga, Tsunehiko

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.45.1793

To investigate the role of the 2'-hydroxy group at the C-13 side chain of docetaxel in the antitumor activity, we prepared several 2',2'-difluoro derivatives of docetaxel and evaluated their cytotoxicity against mouse leukemia and human tumor cell lines a

Full text of DOI:10.1248/cpb.45.1793

NII-Electronic Library Service

Products guided by the article

Product name:[1-Furan-3-yl-meth-(Z)-ylidene]-(4-methoxy-phenyl)-amine

Cas No:1001909-35-8

R&D Labs maybe for 1001909-35-8

Changzhou Jiana Chemical Co.,Ltd

website:http://www.jianachem.com

Contact:86-0519-88731808

Address:Zhenglu Town Wujin City, Jiangsu Province
Joyochem Co., Ltd.

website:http://www.joyochem.com

Contact:0531-82687998

Address:Factory Building 11, Jinan Comprehensive free trade zone, Shandong, China
Chengdu Boon Stream Chemical Industry Co.,Ltd.

Contact:+86-28-83156758

Address:No.859,Dongzikou Road,Jinniu District,Chengdu,Sichuan,P.R.China
HEBEI BRANT PHARMACEUTICAL

Contact:+86-0311-84455288-844

Address:Mayu Industrial Park, Jinzhou, Hebei, China.
Hebei Fulong Import & Export Co., Ltd.

Contact:86-311-87795661

Address:15A19 Zhongyuan Building,368 Youyi North Street,Shijiazhuang 050070,China

Relevant to this article

PREPARATION AND X-RAY CRYSTAL STRUCTURE OF 2-(DIPHENYLOXYMETHYL)AZAFERROCENE

Doi:10.1016/0022-328X(85)87276-4
(1985)
Doi:10.1021/ja01596a077
(1956)
Reusable Ce-V Loaded Alumina Catalyst for Multicomponent Synthesis of Substituted Pyridines in Green Media

Doi:10.1002/jhet.2430
(2016)
Synthesis of the first representatives of benzannelated dihydroselenochromenes [4]

Doi:10.1007/s10593-006-0253-5
(2006)
Total synthesis of polydiscamides B, C, and D via a convergent native chemical ligation-oxidation strategy

Doi:10.1021/ol502045u
(2014)
N -Isopropylsulfinylimines vs. N-tert -butylsulfinylimines in the stereoselective synthesis of sterically hindered amines: An improved synthesis of enantiopure (R)- And (S)-rimantadine and the trifluoromethylated analogues

Doi:10.1039/c9ob02241d
(2019)

Article Doi