Synthesis and structure-activity relationships of novel 2',2'-difluoro analogues of docetaxel

DOI: 10.1248/cpb.45.1793

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1793 - 1804 (1997)

Update date:2022-08-03

Topics: Synthesis Mass spectrometry Structure-activity relationships In vitro Testing In Vivo Testing Gas Chromatography

Authors:

Uoto, Kouichi

Ohsuki, Satoru

Takenoshita, Haruhiro

Ishiyama, Takashi

Iimura, Shin

Hirota, Yasuhide

Mitsui, Ikuo

Terasawa, Hirofumi

Soga, Tsunehiko

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Article abstract of DOI:10.1248/cpb.45.1793

To investigate the role of the 2'-hydroxy group at the C-13 side chain of docetaxel in the antitumor activity, we prepared several 2',2'-difluoro derivatives of docetaxel and evaluated their cytotoxicity against mouse leukemia and human tumor cell lines a

Full text of DOI:10.1248/cpb.45.1793

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