Synthesis and structure-activity relationships of novel 2',2'-difluoro analogues of docetaxel

DOI: 10.1248/cpb.45.1793

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1793 - 1804 (1997)

Update date:2022-08-03

Topics: Synthesis Mass spectrometry Structure-activity relationships In vitro Testing In Vivo Testing Gas Chromatography

Authors:

Uoto, Kouichi

Ohsuki, Satoru

Takenoshita, Haruhiro

Ishiyama, Takashi

Iimura, Shin

Hirota, Yasuhide

Mitsui, Ikuo

Terasawa, Hirofumi

Soga, Tsunehiko

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.45.1793

To investigate the role of the 2'-hydroxy group at the C-13 side chain of docetaxel in the antitumor activity, we prepared several 2',2'-difluoro derivatives of docetaxel and evaluated their cytotoxicity against mouse leukemia and human tumor cell lines a

Full text of DOI:10.1248/cpb.45.1793

NII-Electronic Library Service

Products guided by the article

Product name:[1-Furan-3-yl-meth-(Z)-ylidene]-(4-methoxy-phenyl)-amine

Cas No:1001909-35-8

R&D Labs maybe for 1001909-35-8

shandong lukang animal & plant drug trading co.,ltd.

Contact:15853765968

Address:floor 9, lukang ,jingying building,#173,taibai building west road,jining city,shandong,china
Huaihua Baohua Biotechnology Co.,Ltd

website:http://www.baochengchem.com

Contact:86-519-82698291

Address:HouYang chemical development zone,Jintan,Jiangsu,China (213200)
Sinonine Industry Co.,Ltd

Contact:86+21-56421993

Address:3F,BUILDING 10,NO.2889 JINKE ROAD, SHANGHAI.
Hangzhou Mole's Science & Technology Co.,Ltd.(expird)

Contact:+86-571-56880228

Address:15F Guodu development Building, NO.182 Zhaohui Road
LIDE PHARMACEUTICALS LIMITED

website:http://www.lidepharma.com

Contact:+86-25-58409506

Address:Chungking Express Nos.36 Nathan Road，Kowloon, HK

Relevant to this article

PREPARATION AND X-RAY CRYSTAL STRUCTURE OF 2-(DIPHENYLOXYMETHYL)AZAFERROCENE

Doi:10.1016/0022-328X(85)87276-4
(1985)
Doi:10.1021/ja01596a077
(1956)
Reusable Ce-V Loaded Alumina Catalyst for Multicomponent Synthesis of Substituted Pyridines in Green Media

Doi:10.1002/jhet.2430
(2016)
Synthesis of the first representatives of benzannelated dihydroselenochromenes [4]

Doi:10.1007/s10593-006-0253-5
(2006)
Total synthesis of polydiscamides B, C, and D via a convergent native chemical ligation-oxidation strategy

Doi:10.1021/ol502045u
(2014)
N -Isopropylsulfinylimines vs. N-tert -butylsulfinylimines in the stereoselective synthesis of sterically hindered amines: An improved synthesis of enantiopure (R)- And (S)-rimantadine and the trifluoromethylated analogues

Doi:10.1039/c9ob02241d
(2019)

Article Doi