Chemical and Pharmaceutical Bulletin p. 1793 - 1804 (1997)
Update date:2022-08-03
Topics: Synthesis Mass spectrometry Structure-activity relationships In vitro Testing In Vivo Testing Gas Chromatography 2',2'-difluoro analogues Docetaxel
Uoto, Kouichi
Ohsuki, Satoru
Takenoshita, Haruhiro
Ishiyama, Takashi
Iimura, Shin
Hirota, Yasuhide
Mitsui, Ikuo
Terasawa, Hirofumi
Soga, Tsunehiko
To investigate the role of the 2'-hydroxy group at the C-13 side chain of docetaxel in the antitumor activity, we prepared several 2',2'-difluoro derivatives of docetaxel and evaluated their cytotoxicity against mouse leukemia and human tumor cell lines a
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