HIGHLY ENANTIOSELECTIVE SYNTHESIS OF ANTI(THREO)-ALDOLS BY THE ASYMMETRIC ALDOL REACTION UTILIZING A CHIRAL AZAENOLATE

DOI: 10.1246/cl.1985.1217

Source and publish data:

Chemistry Letters p. 1217 - 1220 (1985)

Update date:2022-08-03

Topics:

Authors:

Narasaka, Koichi

Miwa, Tetsuo

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Article abstract of DOI:10.1246/cl.1985.1217

Diastereo- and enantioselective aldol reaction between 3-pentanone and aldehydes is achieved utilizing a chiral oxazolidine derived from 3-pentanone and chiral norephedrine.The reaction of a tin(II) azaenolate generated from the chiral oxazolidine with aldehydes affords predominantly anti(threo)-aldols of high enantiomeric purity.

Full text of DOI:10.1246/cl.1985.1217

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