HIGHLY ENANTIOSELECTIVE SYNTHESIS OF ANTI(THREO)-ALDOLS BY THE ASYMMETRIC ALDOL REACTION UTILIZING A CHIRAL AZAENOLATE

DOI: 10.1246/cl.1985.1217

Source and publish data:

Chemistry Letters p. 1217 - 1220 (1985)

Update date:2022-08-03

Topics:

Authors:

Narasaka, Koichi

Miwa, Tetsuo

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1246/cl.1985.1217

Diastereo- and enantioselective aldol reaction between 3-pentanone and aldehydes is achieved utilizing a chiral oxazolidine derived from 3-pentanone and chiral norephedrine.The reaction of a tin(II) azaenolate generated from the chiral oxazolidine with aldehydes affords predominantly anti(threo)-aldols of high enantiomeric purity.

Full text of DOI:10.1246/cl.1985.1217

Products guided by the article

Product name:(4S,5R)-2,2-diethyl-4-methyl-5-phenyl-1,3-oxazolidine

Cas No:100420-03-9

R&D Labs maybe for 100420-03-9

Shandong Ailitong New Material Co.,Ltd

Contact:+86-536-3226266

Address:zhongjia village, putong town , qingzhou city,Shandong Province,China
Goldwills Pharmaceuticals Co., Ltd.

Contact:0916-2237889 13991621155

Address:North Suburb of Hanzhong city, Shaanxi Province
Valiant Fine Chemicals Co., Ltd.

Contact:+86 535 6101878/6374484

Address:11 Wuzhishan Rd.,YTETDZ,Yantai,264006,Shandong,China
Zibo Jujin Chemical Industry Co., Ltd.（Dongming Jujin Chemical Industry Co., Ltd. ）

Contact:+86-533-2975022

Address:No.99 Shanquan Road, Zhangdian District
Wuxi Morality Chemical Co., Ltd(expird)

Contact:

Address:B/7F, 321th WuYun Rd, Wanda Plaza, Wuxi City, 214174, China

Relevant to this article

One-step addition of sulfonic acids to acetylene derivatives: An alternative and stereoselective approach to vinyl triflates and fluorosulfonates

Doi:10.1002/ejoc.200700650
(2007)
Doi:10.1021/jo01099a009
(1958)
Three-Component Synthesis of Isoquinoline Derivatives by a Relay Catalysis with a Single Rhodium(III) Catalyst

Doi:10.1021/acs.orglett.9b01456
(2019)
5-O-(4-[¹²⁵I]iodobenzyl)-L-ascorbic acid: Electrophilic radioiodination and biodistribution in mice

Doi:10.1248/cpb.60.235
(2012)
An improved synthesis of cis-4-phenyl-2-propionamidotetralin (4-P-PDOT): A selective MT₂ melatonin receptor antagonist

Doi:10.1039/b713904g
(2008)
Design, synthesis, and evaluation of novel VEGFR2 kinase inhibitors: Discovery of [1,2,4]triazolo[1,5-a]pyridine derivatives with slow dissociation kinetics

Doi:10.1016/j.bmc.2013.04.042
(2013)

Article Doi