Diastereoselective spiroannulation of phenolic substrates: Advances towards the asymmetric formation of the manumycin m-C7N core skeleton

Article abstract of DOI:10.3390/12092215

The asymmetric syntheses of two new spirolactones prepared in optically pure form from L-3-nitrotyrosine are described. The key step, an oxidative spiroannulation, was carried out on the optically active phenols 11a and 11b and afforded the new spirolacto