
Russian Chemical Bulletin p. 667 - 670 (1996)
Update date:2022-08-03
Topics:
Fedenok
Plashchenyuk
Myasnikova
Shvartsberg
Four pathways of synthesis of 1-(2-pyridyl)heptacosa-12,14-diyne, using 10-bromodecan-1-ol and acetylene or tetradec-1-yne and 2-methylbut-3-yn-2-ol along with α-picoline as initial compounds, were studied and compared. It was shown that direct introduction of a completely formed unsaturated hydrocarbon chain into an α-picoline molecule by alkylation of its lithium derivative is the most appropriate method for preparation of long-chain 2-alkadiynylpyridines.
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