THE SYNTHESIS OF AMINO ACIDS BY REACTION OF AN ELECTROPHILIC GLYCINE CATION EQUIVALENT WITH CARBON NUCLEOPHILES

Article abstract of DOI:10.1016/S0040-4039(00)89112-1

Acetate 1, a glycine cation equivalent, is reacted with organocopper reagents to yield products 2 which can readily be converted to the higher amino acids.This method provides access to aryl-substituted amino acids as well as amino acids containing a β-tertiary carbon.