SYNTHESIS OF A COMMON POLYSACCHARIDE ANTIGEN OF PSEUDOMONAS AERUGINOSA AS THE 6-AMINOHEXYL GLYCOSIDE

Article abstract of DOI:10.1016/0008-6215(89)85108-0

The synthesis is described of a tritylated 1,2-O-cyanoethylidene derivative (3) of the trisaccharide α-D-Rha-(1->2)-α-D-Rha-(1->3)-D-Rha.Triphenylmethylium perchlorate-catalysed polycondensation of 3 in the presence of 6-phthalimidohexyl 2,4-di-O-benzoyl-3-O-trityl-α-D-rhamnopyranoside followed by deprotection afforded the 6-aminohexyl glycoside of a D-rhamnan corresponding to a common polysaccharide antigen of Pseudomonas aeruginosa.