STEREOSELECTIVE ANNELATION OF TRIMETHYLSILOXYACETIC ACIDS AND IMINES INTO 3-HYDROXY-β-LACTAMS

Article abstract of DOI:10.1016/S0040-4039(00)99002-6

Stereoselective synthesis of variously substituted 3-hydroxy-β-lactams can be achieved by the annelation of Schiff bases with trimethylsiloxyacetic acids promoted by phenyl dichlorophosphate reagent.A potential synthesis of N-unsubstituted β-lactams is ma