Application of an amidyl radical cascade to the total synthesis of (±)-fortucine leading to the structural revision of kirkine

Article abstract of DOI:10.1016/j.tet.2009.04.027

A radical cascade initiated by a nitrogen-centred (amidyl) radical was developed, allowing the rapid construction of galanthan frameworks. It was applied to a concise, stereo/regio-selective and tin-free total synthesis of the natural product (±)-fortucin