Journal of Medicinal Chemistry p. 4858 - 4865 (1992)
Update date:2022-07-30
Topics: Synthesis Molecular docking Inhibitor In vitro Testing Structure-Activity Relationship (SAR) Pharmacokinetics High-Throughput Screening (HTS) Heterocyclic compound Enzyme inhibition assay IC50 (Half-Maximal Inhibitory Concentration)
Singh, Baldev
Lesher, George Y.
Pluncket, Kevin C.
Pagani, Edward D.
Bode, Donald C.
et al.
Two series of medorinone (3) analogs were prepared by modifications at C(2) and C(5).The C(2)-series was prepared from 2-chloro-5-methyl-1,6-naphthyridine (4) by replacement of the chloro group with various nucleophiles.The C(5)-series was prepared from 5
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(1985)
