Journal of Medicinal Chemistry p. 2296 - 2304 (1990)
Update date:2022-07-30
Topics:
Walsh, David A.
Moran, H. Wayne
Shamblee, Dwight A.
Welstead, William J.
Nolan, Joseph C.
et al.
A series of potential prodrugs of 2-amino-3-benzoylbenzeneacetic acid (amfenac) and 2-amino-3-(4-chlorobenzoyl)benzeneacetic acid were synthesized and evaluated for their cyclooxygenase inhibiting properties, antiinflammatory potency, and gastrointestinal irritation liability.One compound, 2-amino-3-(4-chlorobenzoyl)benzeneacetamide, possessed a therapeutic index 1 order of magnitude greater than that of indomethacin.
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