Kinetic control of proline amide rotamers: Total synthesis of trans,trans- and cis,cis-ceratospongamide

DOI: 10.1021/ja017160a

Source and publish data:

Journal of the American Chemical Society p. 916 - 917 (2002)

Update date:2022-08-04

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Authors:

Deng, Shaojiang

Taunton, Jack

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Article abstract of DOI:10.1021/ja017160a

Ceratospongamide is a cyclic peptide natural product that is biosynthesized as a mixture of two proline rotamers. Remarkably, these rotamers do not detectably interconvert at temperatures up to 100 °C. Here we report high-yielding syntheses of each rotame

Full text of DOI:10.1021/ja017160a

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