Bioorganic and Medicinal Chemistry Letters p. 1497 - 1502 (1996)
Update date:2022-09-26
Topics:
Kundu, Nitya G.
Mahanty, Jyan S.
Spears, C. Paul
5-(Acylethynyl)-1-(2-hydroxyethoxy)methyl uracils (2)-(6) were synthesised in excellent yields from 1-(2-acetoxyethoxy)methyl-5-iodouracil (7) utilising palladium-copper catalysed reactions. Compounds (2)-(5) were shown to be highly active against CCRF-CEM (IC50 0.6-1.6 μM) and L1210/0 cells (IC50 0.7-2.2 μM) in culture, and thus exhibit greater activity than their parent bases.
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