Bioorganic and Medicinal Chemistry Letters p. 1497 - 1502 (1996)
Update date:2022-09-26
Topics:
Kundu, Nitya G.
Mahanty, Jyan S.
Spears, C. Paul
5-(Acylethynyl)-1-(2-hydroxyethoxy)methyl uracils (2)-(6) were synthesised in excellent yields from 1-(2-acetoxyethoxy)methyl-5-iodouracil (7) utilising palladium-copper catalysed reactions. Compounds (2)-(5) were shown to be highly active against CCRF-CEM (IC50 0.6-1.6 μM) and L1210/0 cells (IC50 0.7-2.2 μM) in culture, and thus exhibit greater activity than their parent bases.
View MoreJingzhou TianHe Sci&Tech Chemical Co., Ltd.
Contact:86-716-8331612
Address:Jiangjin Road, #18, High-grade technology industries development district, Jingzhou city, Hubei province
website:http://www.angchenchem.com
Contact:+86-510-88302099 82327577
Address:Rm. 404/405, Floor 4th, No. 983 FengXiang Road, Wuxi, China
Jiaxing Taixin Pharmaceutical Chemical Co., Ltd
Contact:0573-82613601
Address:Chemical Park, Jiaxing, Zhejiang, China
Hangzhou Zyter Biological & Chemical Technology Co., Ltd.
website:http://www.zyterpharm.com
Contact:+86-18858184290
Address:West Wenyi Road, Cangqian, Yuhang
Melone Pharmaceutical Co., ltd
Contact:+86-411 82593920, 82593631
Address:No 232, JInma Roda, Development Zone, Dalian, China
Doi:10.1021/ja801569q
(2008)Doi:10.1016/S0040-4020(01)88177-1
(1986)Doi:10.1055/s-1997-1075
(1997)Doi:10.1016/S0957-4166(97)00586-7
(1997)Doi:10.1016/j.cclet.2019.03.019
(2019)Doi:10.1021/jm701443n
(2008)
