Unusual cytotoxicities of 5-(acylethynyl)-1-(2- hydroxyethoxy)methyluracils

DOI: 10.1016/S0960-894X(96)00256-9

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1497 - 1502 (1996)

Update date:2022-09-26

Topics:

Authors:

Kundu, Nitya G.

Mahanty, Jyan S.

Spears, C. Paul

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Article abstract of DOI:10.1016/S0960-894X(96)00256-9

5-(Acylethynyl)-1-(2-hydroxyethoxy)methyl uracils (2)-(6) were synthesised in excellent yields from 1-(2-acetoxyethoxy)methyl-5-iodouracil (7) utilising palladium-copper catalysed reactions. Compounds (2)-(5) were shown to be highly active against CCRF-CEM (IC₅₀ 0.6-1.6 μM) and L1210/0 cells (IC₅₀ 0.7-2.2 μM) in culture, and thus exhibit greater activity than their parent bases.

Full text of DOI:10.1016/S0960-894X(96)00256-9

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