Bioorganic and Medicinal Chemistry Letters p. 1497 - 1502 (1996)
Update date:2022-09-26
Topics:
Kundu, Nitya G.
Mahanty, Jyan S.
Spears, C. Paul
5-(Acylethynyl)-1-(2-hydroxyethoxy)methyl uracils (2)-(6) were synthesised in excellent yields from 1-(2-acetoxyethoxy)methyl-5-iodouracil (7) utilising palladium-copper catalysed reactions. Compounds (2)-(5) were shown to be highly active against CCRF-CEM (IC50 0.6-1.6 μM) and L1210/0 cells (IC50 0.7-2.2 μM) in culture, and thus exhibit greater activity than their parent bases.
View MoreShandong Topscience Biotech Co., Ltd.
Contact:0633-2619278
Address:No. 98 Lanshan West Road, Lanshan District, Rizhao, Shandong Province, P.R. of China
WUXI HONOR SHINE CHEMICAL CO.,LTD
Contact:+86-510-83593312
Address:No.1699 Huishan avenue,Huishan district,Wuxi ,Jiangsu,China,214177.(Wuxi Huishan Ecomonic Develop Zone )
Nanjing Chemzam Pharmtech Co., Ltd.
Contact:+86-25-86462165,+86-13915979898
Address:C5-1，6 Maiyue Road，Maigaoqiao，Nanjing，Jiangsu，China
Tangshan Wisdom Trading Co.,Ltd
Contact:86 315 2222979
Address:No.41 BeiXinXi Road, Yangguang building 1-1102 , Tangshan, Hebei, China
website:http://www.apeptides.com/en/
Contact:+86-21-60871011
Address:No. 80 Chuanshan Shuyuan Steet,Pudong,Shanghai
Doi:10.1021/ja801569q
(2008)Doi:10.1016/S0040-4020(01)88177-1
(1986)Doi:10.1055/s-1997-1075
(1997)Doi:10.1016/S0957-4166(97)00586-7
(1997)Doi:10.1016/j.cclet.2019.03.019
(2019)Doi:10.1021/jm701443n
(2008)
