AN APPLICATION OF THE SUAREZ REACTION TO THE REGIOSPECIFIC AND STEREOSPECIFIC SYNTHESIS OF THE C28-C42 SEGMENT OF RAPAMYCIN

Article abstract of DOI:10.1016/S0040-4039(00)60597-X

Specific lactonization of a TBS ether followed by iodinative scission of a γ-lactol are the key elements of a strategy for maintaining continuous chemical distinction between the latent C34 and C32 hydroxyl groups of starting material 3 en route to 14, the C28-C42 fragment of rapamycin.