Organocatalytic double Michael reaction of 7-oxohept-2-enoates and nitrostyrene - Formal synthesis of (-)-α- and (-)-β-lycorane

Article abstract of DOI:10.1002/ejoc.200701122

Organocatalytic conjugate addition of 7-oxohept-2-enoate to nitrostyrene provided an ω-nitro-α,β-unsaturated ester. Subsequent intramolecular cyclization afforded the highly functionalized cyclohexane carboester with four stereogenic centers with high dia