Synthesis of 8-Amino-3-deazaguanine via Imidazole Precursors. Antitumor Activity and Inhibition of Purine Nucleoside Phosphorylase

DOI: 10.1021/jm00160a040

Source and publish data:

Journal of Medicinal Chemistry p. 2034 - 2037 (1986)

Update date:2022-08-03

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Authors:

Berry, David A.

Gilbertsen, Richard B.

Cook, P. Dan

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Article abstract of DOI:10.1021/jm00160a040

8-Amino-3-deazaguanine (15), an analogue of both 3-deazaguanine (1) and 8-aminoguanine (6), an antitumor agent and a purine nucleoside phosphorylase (PNP) inhibitor, respectively, was synthesized from the ammonolysis of an imidazole precursor, methyl 2-(b

Full text of DOI:10.1021/jm00160a040

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