The design and synthesis of diaryl ether second generation HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) with enhanced potency versus key clinical mutations

DOI: 10.1016/j.bmcl.2008.03.064

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2959 - 2966 (2008)

Update date:2022-08-03

Topics:

Authors:

Tucker, Thomas J.

Saggar, Sandeep

Sisko, John T.

Tynebor, Robert M.

Williams, Theresa M.

Felock, Peter J.

Flynn, Jessica A.

Lai, Ming-Tain

Liang, Yuexia

McGaughey, Georgia

Liu, Meiquing

Miller, Mike

Moyer, Gregory

Munshi, Vandna

Perlow-Poehnelt, Rebecca

Prasad, Sridhar

Sanchez, Rosa

Torrent, Maricel

Vacca, Joseph P.

Wan, Bang-Lin

Yan, Youwei

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Article abstract of DOI:10.1016/j.bmcl.2008.03.064

Using a combination of traditional Medicinal Chemistry/SAR analysis, crystallography, and molecular modeling, we have designed and synthesized a series of novel, highly potent NNRTIs that possess broad antiviral activity against a number of key clinical mutations.

Full text of DOI:10.1016/j.bmcl.2008.03.064

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