Benzimidazole condensed ring system. IX. Potential antineoplastics. New synthesis of some pyridobenzimidazoles and related derivatives

Article abstract of DOI:10.1016/0223-5234(96)88241-9

Some pyrido<1,2-a>benzimidazoles were prepared in order to investigate their in vitro antineoplastic and anti-HIV activities.Two compounds (9b, NSC 658526 and 15, NSC 664715) showed a variable degree of antineoplastic activity against some of the cell lines tested.Compound 9a (NSC 649900) exhibited a good in vitro antineoplastic activity with subpanel disease selectivity, particularly against most of the cell lines of leukemia and some cell lines from colon, melanoma and renal cancer panels. 2-acetylbutyrolactone/ pyrido<1,2-a>benzimidazole/ antineoplastic activity