SYNTHESIS OF ANTITUMOR-ACTIVE 7-O-(2,6-DIDEOXY-2-FLUORO-α-L-TALOPYRANOSYL)-DAUNOMYCINONE AND -ADRIAMYCINONE

Article abstract of DOI:10.1016/0008-6215(87)80243-4

The title compounds (17 and 23) were prepared by coupling 3,4-di-O-acetyl-2,6-dideoxy-2-fluoro-α-L-talopyranosyl bromide (15) with daunomycinone.The key step in the preparation of 15 was the epoxide-ring opening of methyl 2,3-anhydro-4-O-benzyl-6-deoxy-α-