SYNTHESIS OF 2-(2-ARYLAMINO-3-ALKYLOXAZOLIDINYL-4-)- AND 2-(2-ARYLAMINO-3-ALKYLTHIAZOLIDINYL-4)-N-ALKYLACETAMIDES FROM 2(5H)-FURANONE

Article abstract of DOI:10.1007/BF00842956

Aminolysis of 2(5H)-furanone leads to 3-alkylamino-4-hydroxy-N-alkylbutyramides which easily form hydroxy derivatives of thiourea.The latter, depending on the protonation or quaternization site, easily undergo cyclization to thiazolidine and oxazolidine derivatives.