Tetrahedron Letters p. 5433 - 5436 (1985)
Update date:2022-08-03
Topics:
Kunisch, Franz
Hobert, Kurt
Welzel, Peter
The synthesis of the optically active 4 has been accomplished by asymmetric formation of cyclic β-keto esters fully substituted at the α Carbon followed by chemoselective reduction of the ester group.Of the asymmetric reactions examined the Koga procedure proved to be the most selective.
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Doi:10.1021/jm800737y
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