ASYMMETRIC ALDOL REACTION OF AMIDE ENOLATES BEARING trans-2,5-DISUBSTITED PYRROLIDINES AS CHIRAL AUXILIARIES

Article abstract of DOI:10.1016/S0040-4039(00)98932-9

Condensation of aldehydes with Zr enolate of chiral N-propionyl-trans-2,5-disubstituted pyrrolidine proceeded with high diastereo- and diastereofaceselection.Stereoselectivity in the reaction of the corresponding N-acetyl compounds was also examined.