Chemical and Pharmaceutical Bulletin p. 935 - 941 (1992)
Update date:2022-09-26
Topics:
Shibata
Takegawa
Koizumi
Yamakoshi
Shimazawa
2-Azachlormadinone acetate (5a, 17-acetoxy-6-chloro-2-azapregna-4,6-diene-3,20-dione), 2-oxachlormadinone acetate (6, 17-acetoxy-6-chloro-2-oxapregna-4,6-diene-3,20-dione) and the derivatives were prepared as potential antiandrogenic agents. Biological evaluation showed that 5a and 6 had a potent antiandrogenic activity when tested in the castrated male rat.
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