Substituted 1,3,4-Thiadiazoles with Anticonvulsant Activity. 3. Guanidines

Article abstract of DOI:10.1021/jm00388a038

The synthesis and anticonvulsant activity of a number of 2-aryl-5-guanidino-1,3,4 thiadiazoles are described.The unsubstituted guanidine 2a was found to possess potent anticonvulsant properties; considerable reduction or loss of activity however was observed with the majority of the substituted guanidines.Incorporation of the guanidine group into an imidazoline ring also resulted in a loss of activity.Secondary pharmacological evaluation confirmed the anticonvulsant properties of 2a but also revelated that the compound exibited a considerable degree of sedative activity.