Journal of Medicinal Chemistry p. 951 - 954 (1987)
Update date:2022-08-03
Topics:
Chapleo, Christopher B.
Myers, Peter L.
Smith, Alan C. B.
Tulloch, Ian F.
Walter, Donald S.
The synthesis and anticonvulsant activity of a number of 2-aryl-5-guanidino-1,3,4 thiadiazoles are described.The unsubstituted guanidine 2a was found to possess potent anticonvulsant properties; considerable reduction or loss of activity however was observed with the majority of the substituted guanidines.Incorporation of the guanidine group into an imidazoline ring also resulted in a loss of activity.Secondary pharmacological evaluation confirmed the anticonvulsant properties of 2a but also revelated that the compound exibited a considerable degree of sedative activity.
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