Bioorganic and Medicinal Chemistry Letters p. 5182 - 5185 (2008)
Update date:2022-07-30
Topics:
Popsavin, Velimir
Sreco, Bojana
Benedekovic, Goran
Popsavin, Mirjana
Francuz, Jovana
Kojic, Vesna
Bogdanovic, Gordana
Two new (-)-muricatacin mimics bearing a furano-furanone ring and an oxygen isostere in the side chain have been designed and synthesized and their in vitro antiproliferative activity was evaluated against several human tumour cell lines. Both analogues showed an increased activity against HL-60 cells with 17- and 185-fold higher potency than (-)-muricatacin. A straightforward synthesis of (-)-muricatacin is also disclosed.
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(2008)
