Tetrahedron Letters p. 4103 - 4106 (1986)
Update date:2022-08-04
Topics: Total synthesis Antitumor agent Cytotoxic activity Isolation and Characterization Structure-Activity Relationship Experimental procedure CC-1065
Warpehoski, M.A.
The synthesis of U-71,184 (2), a highly potent analog of the novel antitumor antibiotic CC-1065, is described, the penultimate step of which involves the unmasking of a p-hydroxy phenethyl mesylate, which undergoes facile intramolecular elimination to aff
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