Synthesis p. 64 - 65 (1987)
Update date:2022-08-03
Topics: -Synthesis -Catalyst -Alkylation -Reduction
Ayyangar, N. R.
Brahme, K. C.
Srinivasan, K. V.
An elegant, cost-effective synthesis of clonidine (4) is reported from readily available starting materials. o-Chlorophenylhydroxylamine (2), obtained from o-chloronitrobenzene, is formylated to N-(2-chlorophenyl)-N-hydroxyformamide (3).In a one-pot procedure, 3 is converted to clonidine by chlorination with thionyl chloride and then with thionyl chloride/sulfuryl chloride, followed by condensation with ethylenediamine.
View Morewebsite:http://www.angchenchem.com
Contact:+86-510-88302099 82327577
Address:Rm. 404/405, Floor 4th, No. 983 FengXiang Road, Wuxi, China
Shanghai Send Pharmaceutical Technology Co., Ltd.
website:http://www.shsendpharma.com
Contact:021-58088081, +8613585868794
Address::Room A601, Building 1,NO. 800 Qingdai Road Pudong District Shanghai,China
NINGBO YINZHOU PRECISE COLOR CO.,LTD.
Contact:86-574-88139809 86-574-83033159
Address:Qiming Road,Yinzhou,Ningbo,China
Shaanxi HuaTai Bio-fine chemical company Ltd
Contact:86-029-87862197
Address:No. 5, 3rd Floor, 29 Yanta North Road, Beilin Dist.
Weifang Adde Economic And Trade Co.,LTD.
Contact:86-536-8885548
Address:Room 1402,Wanda Plaza B Block,No.958,Yuanfei Road,Kuiwen District
Doi:10.1002/hlca.19870700123
(1987)Doi:10.1016/j.bmcl.2011.06.136
(2011)Doi:10.1021/ol0490375
(2004)Doi:10.1021/om800857k
(2009)Doi:10.1021/acs.joc.1c00967
(2021)Doi:10.1016/j.bmcl.2011.03.084
(2011)
