Nitrogen-bridged conformationally constrained etorphine analogues. Synthesis and biological evaluation

DOI: 10.1021/jm00394a016

Source and publish data:

Journal of Medicinal Chemistry p. 2016 - 2026 (1987)

Update date:2022-07-31

Topics: Synthesis Analogues Biological Evaluation Conformationally constrained

Authors:

Maurer Maurer

Rapoport

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Article abstract of DOI:10.1021/jm00394a016

Three N-C8-bridged analogues 4-6 of the opiate etorphine (3) were synthesized and evaluated for opiate agonism and antagonism. In each case ring closure was effected by intramolecular N-alkylation with a suitably developed C8 side chain. Another key synth

Full text of DOI:10.1021/jm00394a016

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