Nitrogen-bridged conformationally constrained etorphine analogues. Synthesis and biological evaluation

DOI: 10.1021/jm00394a016

Source and publish data:

Journal of Medicinal Chemistry p. 2016 - 2026 (1987)

Update date:2022-07-31

Topics: Synthesis Analogues Biological Evaluation Conformationally constrained

Authors:

Maurer Maurer

Rapoport

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00394a016

Three N-C8-bridged analogues 4-6 of the opiate etorphine (3) were synthesized and evaluated for opiate agonism and antagonism. In each case ring closure was effected by intramolecular N-alkylation with a suitably developed C8 side chain. Another key synth

Full text of DOI:10.1021/jm00394a016

Products guided by the article

Product name:N-benzoylnorthebaine

Cas No:110173-63-2

R&D Labs maybe for 110173-63-2

ZHEJIANG CHEMICAL INDUSTRY INSTITUTE TECHNOLOGY CO.,LTD(expird)

Contact:86-575-82730298

Address:shangyu
Shanghai Sungo Technology Chemical Co., Ltd

Contact:0086-21-51385579

Address:Room2010, F/20, Tonghua Plaza, NO 345 Jinxiang Road, Jinqiao Export Processing Zone, Shanghai, 201206 P.R.CHINA
STAR SYNTHESIS CO.,LIMITED

Contact:+(852) 301-98033

Address:Flat C, 23/F, Lucky Plaza, 315-321 Lockhart Road, Wan Chai, Hong Kong
ANHUI CHEM-BRIGHT BIOENGINEERING CO.,LTD

Contact:86-561-4080321

Address:No.8 Lieshan Industrial Zone of Huaibei
Wuhan Better Organic Technology Inc.

Contact:13307163183

Address:Wuhan Economic&Technology Development Zone, Hubei

Relevant to this article

Convergent Synthesis of Fluorene Derivatives by a Rhodium-Catalyzed Stitching Reaction/Alkene Isomerization Sequence

Doi:10.1002/chem.201901519
(2019)
Total Synthesis of Antibiotic Hygromycin A

Doi:10.1021/jo00009a009
(1991)
Haller-Bauer Cleavage of Open-Chain and Cyclic α-Phenyl Ketones Proceeds with Retention of Configuration

Doi:10.1021/ja00256a054
(1987)
Spectroscopic study of the keto-enol equilibrium of N- aryldiacetylthioacetamides and their reactivity

Doi:10.1007/s10593-008-0051-3
(2008)
Neutral lithium triflate (LiOTf) efficiently catalyzes chemoselective preparations of cyclic and acyclic dithioacetals from carbonyl compounds, acylals, and O,O-cyclic and open-chain acetals under solvent-free conditions

Doi:10.1246/bcsj.74.2401
(2001)
Arylmethylene derivatives of 5-R-3H-furan-2-ones and N-aryl-5-R-3H-pyrrol- 2-ones in reaction with acetylacetone

Doi:10.1007/s10593-007-0188-5
(2007)

Article Doi