An approach to the desulfurization of oligonucleotide phosphorothioates

DOI: 10.1016/S0040-4039(03)00322-8

Source and publish data:

Tetrahedron Letters p. 2501 - 2504 (2003)

Update date:2022-08-04

Topics:

Authors:

Reese, Colin B.

Yan, Hongbin

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Article abstract of DOI:10.1016/S0040-4039(03)00322-8

Protected oligonucleotide phosphorothioates are converted by a two-step procedure into oligonucleotides with standard phosphodiester internucleotide linkages. The remaining protecting groups are then removed by ammonolysis.

Full text of DOI:10.1016/S0040-4039(03)00322-8

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