(Z)-dimethyl α-(bromomethyl)fumarate, an efficient intermediate for the selective synthesis of dimethyl 3-alkyl itaconates and 2-alkyl 3- carbomethoxy-γ-lactams

Article abstract of DOI:10.1016/S0040-4020(99)00118-0

(Z)-Dimethyl α-(bromomethyl)fumarate 2 proved to be an efficient precursor of 3-substituted itaconic acid esters 3 via its reaction with magnesium dialkylcuprates. Some hindered esters 3 can be used for the diastereoselective synthesis of α-alkylated-β-me