The discovery of potent antitumor agent C11-deoxypsymberin/irciniastatin a: Total synthesis and biology of advanced psymberin analogs

DOI: 10.1021/ol802772s

Source and publish data:

Organic Letters p. 867 - 870 (2009)

Update date:2022-08-05

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Authors:

Huang, Xianhai

Shao, Ning

Huryk, Robert

Palani, Anandan

Aslanian, Robert

Seidel-Dugan, Cynthia

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Article abstract of DOI:10.1021/ol802772s

Structure-activity relationship (SAR) studies by modification of the unsaturated side chain of potent anticancer marine natural product psymberin/irciniastatin A (1) suggest that substitution at C4 and C5 is important for the cytotoxicity of psymberin, bu

Full text of DOI:10.1021/ol802772s

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