Pumiliotoxin Alkaloids: Relationship of Cardiotonic Activity to Sodium Channel Activity and Phosphatidylinositol Turnover

DOI: 10.1021/jm00397a036

Source and publish data:

Journal of Medicinal Chemistry p. 477 - 480 (1988)

Update date:2022-07-30

Topics:

Authors:

Daly, J.W.

McNeal, E.

Gusovsky, F.

Ito, F. Ito, F.

Overman, L.E.

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Article abstract of DOI:10.1021/jm00397a036

The cardiotonic activity of pumiliotoxin B (PTX-B, 6-(6',7'-dihydroxy-2',5'-dimethyl-(E)-4'-octenylidene)-8-hydroxy-8-methyl-1-azabicyclo<4.3.0>nonane) as assessed in guinea pig atrial preparations is markedly dependent on the nature of the 6-alkylidene s

Full text of DOI:10.1021/jm00397a036

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